| Full name: phosphoinositide-3-kinase regulatory subunit 6 | Alias Symbol: FLJ34500|HsT41028|p87PIKAP | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 146850 | HGNC ID: HGNC:27101 | Ensembl Gene: ENSG00000276231 | OMIM ID: 611462 |
| Drug and gene relationship at DGIdb | |||
Expression of PIK3R6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PIK3R6 | 146850 | 1558770_a_at | -0.0549 | 0.9109 | |
| GSE26886 | PIK3R6 | 146850 | 1558770_a_at | 0.1031 | 0.4034 | |
| GSE45670 | PIK3R6 | 146850 | 1558770_a_at | -0.0842 | 0.3133 | |
| GSE53622 | PIK3R6 | 146850 | 62206 | -0.3474 | 0.0063 | |
| GSE53624 | PIK3R6 | 146850 | 81043 | -0.4648 | 0.0002 | |
| GSE63941 | PIK3R6 | 146850 | 1558770_a_at | 0.0877 | 0.5492 | |
| GSE77861 | PIK3R6 | 146850 | 1558770_a_at | -0.0270 | 0.7815 | |
| GSE97050 | PIK3R6 | 146850 | A_24_P366509 | 0.3664 | 0.5391 | |
| SRP007169 | PIK3R6 | 146850 | RNAseq | 0.7703 | 0.4048 | |
| SRP064894 | PIK3R6 | 146850 | RNAseq | 0.2185 | 0.4926 | |
| SRP133303 | PIK3R6 | 146850 | RNAseq | -0.7960 | 0.0055 | |
| SRP159526 | PIK3R6 | 146850 | RNAseq | -0.4984 | 0.2062 | |
| SRP193095 | PIK3R6 | 146850 | RNAseq | -0.6016 | 0.0146 | |
| SRP219564 | PIK3R6 | 146850 | RNAseq | 0.4515 | 0.3367 | |
| TCGA | PIK3R6 | 146850 | RNAseq | 0.1522 | 0.5368 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PIK3R6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PIK3R6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PIK3R6 | 146850 | 3 | 2 | 25 | |
| GSE20123 | PIK3R6 | 146850 | 3 | 3 | 24 | |
| GSE43470 | PIK3R6 | 146850 | 1 | 6 | 36 | |
| GSE46452 | PIK3R6 | 146850 | 34 | 1 | 24 | |
| GSE47630 | PIK3R6 | 146850 | 7 | 1 | 32 | |
| GSE54993 | PIK3R6 | 146850 | 4 | 3 | 63 | |
| GSE54994 | PIK3R6 | 146850 | 5 | 8 | 40 | |
| GSE60625 | PIK3R6 | 146850 | 4 | 0 | 7 | |
| GSE74703 | PIK3R6 | 146850 | 1 | 3 | 32 | |
| GSE74704 | PIK3R6 | 146850 | 1 | 1 | 18 | |
| TCGA | PIK3R6 | 146850 | 17 | 20 | 59 |
Total number of gains: 80; Total number of losses: 48; Total Number of normals: 360.
Somatic mutations of PIK3R6:
Generating mutation plots.
Highly correlated genes for PIK3R6:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PIK3R6 | TNFSF8 | 0.753093 | 4 | 0 | 3 |
| PIK3R6 | GAPT | 0.732176 | 3 | 0 | 3 |
| PIK3R6 | TMEM176B | 0.731965 | 3 | 0 | 3 |
| PIK3R6 | HLA-DMA | 0.7212 | 4 | 0 | 4 |
| PIK3R6 | GAB3 | 0.720025 | 4 | 0 | 4 |
| PIK3R6 | PARVG | 0.718194 | 5 | 0 | 5 |
| PIK3R6 | APOL3 | 0.716287 | 3 | 0 | 3 |
| PIK3R6 | C1orf162 | 0.711092 | 4 | 0 | 4 |
| PIK3R6 | CD2 | 0.70915 | 4 | 0 | 3 |
| PIK3R6 | PYHIN1 | 0.707544 | 3 | 0 | 3 |
| PIK3R6 | TMEM176A | 0.706054 | 3 | 0 | 3 |
| PIK3R6 | IRF8 | 0.701633 | 4 | 0 | 3 |
| PIK3R6 | BIN2 | 0.699717 | 4 | 0 | 4 |
| PIK3R6 | KCNA3 | 0.693728 | 4 | 0 | 3 |
| PIK3R6 | CD3D | 0.691875 | 4 | 0 | 3 |
| PIK3R6 | INPP5D | 0.690339 | 4 | 0 | 4 |
| PIK3R6 | TMEM140 | 0.690265 | 3 | 0 | 3 |
| PIK3R6 | SLC2A5 | 0.689043 | 3 | 0 | 3 |
| PIK3R6 | CCR4 | 0.688798 | 3 | 0 | 3 |
| PIK3R6 | PSAP | 0.687526 | 3 | 0 | 3 |
For details and further investigation, click here
