| Full name: SEC63 homolog, protein translocation regulator | Alias Symbol: SEC63L|PRO2507|ERdj2|DNAJC23 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 11231 | HGNC ID: HGNC:21082 | Ensembl Gene: ENSG00000025796 | OMIM ID: 608648 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC63:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC63 | 11231 | 201916_s_at | -0.2322 | 0.5396 | |
| GSE20347 | SEC63 | 11231 | 201916_s_at | 0.0954 | 0.6109 | |
| GSE23400 | SEC63 | 11231 | 201916_s_at | 0.3790 | 0.0000 | |
| GSE26886 | SEC63 | 11231 | 201916_s_at | -0.2843 | 0.2820 | |
| GSE29001 | SEC63 | 11231 | 201916_s_at | 0.3775 | 0.1361 | |
| GSE38129 | SEC63 | 11231 | 201916_s_at | 0.0543 | 0.7224 | |
| GSE45670 | SEC63 | 11231 | 201916_s_at | -0.1016 | 0.4187 | |
| GSE53622 | SEC63 | 11231 | 24247 | -0.0585 | 0.4742 | |
| GSE53624 | SEC63 | 11231 | 24247 | 0.1125 | 0.0983 | |
| GSE63941 | SEC63 | 11231 | 201916_s_at | -1.5003 | 0.0032 | |
| GSE77861 | SEC63 | 11231 | 201916_s_at | 0.0582 | 0.8721 | |
| GSE97050 | SEC63 | 11231 | A_23_P214977 | -0.1179 | 0.6112 | |
| SRP007169 | SEC63 | 11231 | RNAseq | 0.5609 | 0.0704 | |
| SRP008496 | SEC63 | 11231 | RNAseq | 0.4692 | 0.0079 | |
| SRP064894 | SEC63 | 11231 | RNAseq | 0.2242 | 0.1558 | |
| SRP133303 | SEC63 | 11231 | RNAseq | 0.3040 | 0.0529 | |
| SRP159526 | SEC63 | 11231 | RNAseq | 0.1006 | 0.5187 | |
| SRP193095 | SEC63 | 11231 | RNAseq | 0.0041 | 0.9720 | |
| SRP219564 | SEC63 | 11231 | RNAseq | 0.1216 | 0.7290 | |
| TCGA | SEC63 | 11231 | RNAseq | -0.1623 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEC63 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC63:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC63 | 11231 | 2 | 3 | 25 | |
| GSE20123 | SEC63 | 11231 | 2 | 2 | 26 | |
| GSE43470 | SEC63 | 11231 | 3 | 1 | 39 | |
| GSE46452 | SEC63 | 11231 | 2 | 11 | 46 | |
| GSE47630 | SEC63 | 11231 | 9 | 4 | 27 | |
| GSE54993 | SEC63 | 11231 | 3 | 2 | 65 | |
| GSE54994 | SEC63 | 11231 | 8 | 8 | 37 | |
| GSE60625 | SEC63 | 11231 | 0 | 2 | 9 | |
| GSE74703 | SEC63 | 11231 | 2 | 1 | 33 | |
| GSE74704 | SEC63 | 11231 | 0 | 0 | 20 | |
| TCGA | SEC63 | 11231 | 5 | 23 | 68 |
Total number of gains: 36; Total number of losses: 57; Total Number of normals: 395.
Somatic mutations of SEC63:
Generating mutation plots.
Highly correlated genes for SEC63:
Showing top 20/610 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC63 | ZNF547 | 0.780759 | 3 | 0 | 3 |
| SEC63 | RAD21 | 0.777321 | 3 | 0 | 3 |
| SEC63 | ANKRD44 | 0.766474 | 3 | 0 | 3 |
| SEC63 | WDR73 | 0.758113 | 3 | 0 | 3 |
| SEC63 | ZNF397 | 0.742419 | 3 | 0 | 3 |
| SEC63 | SNX18 | 0.742155 | 3 | 0 | 3 |
| SEC63 | CBLL1 | 0.741694 | 4 | 0 | 3 |
| SEC63 | DECR1 | 0.727214 | 3 | 0 | 3 |
| SEC63 | FNBP4 | 0.723042 | 4 | 0 | 3 |
| SEC63 | STRN3 | 0.715193 | 3 | 0 | 3 |
| SEC63 | TMEM181 | 0.707451 | 5 | 0 | 5 |
| SEC63 | SGTB | 0.706945 | 4 | 0 | 4 |
| SEC63 | ZFAND5 | 0.705569 | 3 | 0 | 3 |
| SEC63 | SNX13 | 0.701511 | 4 | 0 | 4 |
| SEC63 | ZMAT3 | 0.700956 | 3 | 0 | 3 |
| SEC63 | RRN3 | 0.700594 | 4 | 0 | 3 |
| SEC63 | HOOK3 | 0.697519 | 4 | 0 | 3 |
| SEC63 | PCGF3 | 0.692744 | 3 | 0 | 3 |
| SEC63 | FAM160B1 | 0.691398 | 4 | 0 | 3 |
| SEC63 | SKAP2 | 0.689991 | 4 | 0 | 4 |
For details and further investigation, click here
