| Full name: Rap guanine nucleotide exchange factor 5 | Alias Symbol: KIAA0277|GFR|MR-GEF | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 9771 | HGNC ID: HGNC:16862 | Ensembl Gene: ENSG00000136237 | OMIM ID: 609527 |
| Drug and gene relationship at DGIdb | |||
RAPGEF5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway |
Expression of RAPGEF5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEF5 | 9771 | 204681_s_at | -0.1425 | 0.8577 | |
| GSE20347 | RAPGEF5 | 9771 | 204681_s_at | 0.0571 | 0.7806 | |
| GSE23400 | RAPGEF5 | 9771 | 204681_s_at | 0.1789 | 0.0511 | |
| GSE26886 | RAPGEF5 | 9771 | 204681_s_at | 0.2595 | 0.4177 | |
| GSE29001 | RAPGEF5 | 9771 | 204681_s_at | -0.4351 | 0.2704 | |
| GSE38129 | RAPGEF5 | 9771 | 204681_s_at | 0.1726 | 0.3154 | |
| GSE45670 | RAPGEF5 | 9771 | 204681_s_at | 0.1536 | 0.4534 | |
| GSE53622 | RAPGEF5 | 9771 | 4648 | -0.6251 | 0.0000 | |
| GSE53624 | RAPGEF5 | 9771 | 4648 | -0.3705 | 0.0000 | |
| GSE63941 | RAPGEF5 | 9771 | 204681_s_at | 3.2184 | 0.0012 | |
| GSE77861 | RAPGEF5 | 9771 | 204681_s_at | 0.2613 | 0.5083 | |
| GSE97050 | RAPGEF5 | 9771 | A_33_P3221618 | 0.0582 | 0.8023 | |
| SRP007169 | RAPGEF5 | 9771 | RNAseq | -0.6462 | 0.0629 | |
| SRP008496 | RAPGEF5 | 9771 | RNAseq | -0.3327 | 0.2280 | |
| SRP064894 | RAPGEF5 | 9771 | RNAseq | -0.0426 | 0.8855 | |
| SRP133303 | RAPGEF5 | 9771 | RNAseq | -0.2367 | 0.3200 | |
| SRP159526 | RAPGEF5 | 9771 | RNAseq | -0.3607 | 0.1094 | |
| SRP193095 | RAPGEF5 | 9771 | RNAseq | -0.4555 | 0.0044 | |
| SRP219564 | RAPGEF5 | 9771 | RNAseq | -0.0106 | 0.9830 | |
| TCGA | RAPGEF5 | 9771 | RNAseq | 0.2257 | 0.0028 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RAPGEF5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEF5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEF5 | 9771 | 17 | 1 | 12 | |
| GSE20123 | RAPGEF5 | 9771 | 17 | 1 | 12 | |
| GSE43470 | RAPGEF5 | 9771 | 4 | 0 | 39 | |
| GSE46452 | RAPGEF5 | 9771 | 10 | 2 | 47 | |
| GSE47630 | RAPGEF5 | 9771 | 9 | 1 | 30 | |
| GSE54993 | RAPGEF5 | 9771 | 0 | 6 | 64 | |
| GSE54994 | RAPGEF5 | 9771 | 20 | 2 | 31 | |
| GSE60625 | RAPGEF5 | 9771 | 0 | 0 | 11 | |
| GSE74703 | RAPGEF5 | 9771 | 4 | 0 | 32 | |
| GSE74704 | RAPGEF5 | 9771 | 11 | 1 | 8 | |
| TCGA | RAPGEF5 | 9771 | 57 | 4 | 35 |
Total number of gains: 149; Total number of losses: 18; Total Number of normals: 321.
Somatic mutations of RAPGEF5:
Generating mutation plots.
Highly correlated genes for RAPGEF5:
Showing top 20/27 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEF5 | SRCIN1 | 0.698471 | 3 | 0 | 3 |
| RAPGEF5 | FBXO22 | 0.68878 | 4 | 0 | 3 |
| RAPGEF5 | C2orf81 | 0.686622 | 3 | 0 | 3 |
| RAPGEF5 | PPIH | 0.683669 | 3 | 0 | 3 |
| RAPGEF5 | KCNQ1 | 0.669997 | 3 | 0 | 3 |
| RAPGEF5 | NUP98 | 0.663303 | 3 | 0 | 3 |
| RAPGEF5 | RNF43 | 0.658343 | 3 | 0 | 3 |
| RAPGEF5 | C15orf40 | 0.655643 | 4 | 0 | 4 |
| RAPGEF5 | ELMO3 | 0.648589 | 4 | 0 | 4 |
| RAPGEF5 | TP73 | 0.628303 | 4 | 0 | 3 |
| RAPGEF5 | PCSK9 | 0.586353 | 3 | 0 | 3 |
| RAPGEF5 | EBP | 0.584277 | 4 | 0 | 3 |
| RAPGEF5 | POR | 0.583724 | 5 | 0 | 3 |
| RAPGEF5 | TCFL5 | 0.573861 | 4 | 0 | 3 |
| RAPGEF5 | GOLGA7B | 0.570842 | 4 | 0 | 3 |
| RAPGEF5 | EML6 | 0.559299 | 5 | 0 | 3 |
| RAPGEF5 | FERMT1 | 0.55729 | 7 | 0 | 4 |
| RAPGEF5 | IGSF3 | 0.546622 | 7 | 0 | 4 |
| RAPGEF5 | SLC1A4 | 0.544005 | 6 | 0 | 3 |
| RAPGEF5 | OIP5 | 0.528098 | 5 | 0 | 3 |
For details and further investigation, click here
