| Full name: proprotein convertase subtilisin/kexin type 9 | Alias Symbol: NARC-1|FH3 | ||
| Type: protein-coding gene | Cytoband: 1p32.3 | ||
| Entrez ID: 255738 | HGNC ID: HGNC:20001 | Ensembl Gene: ENSG00000169174 | OMIM ID: 607786 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK9 | 255738 | 227759_at | 1.4570 | 0.0736 | |
| GSE26886 | PCSK9 | 255738 | 227759_at | 1.3063 | 0.0002 | |
| GSE45670 | PCSK9 | 255738 | 227759_at | 1.0558 | 0.0023 | |
| GSE53622 | PCSK9 | 255738 | 41919 | 0.3967 | 0.0002 | |
| GSE53624 | PCSK9 | 255738 | 38762 | 2.7769 | 0.0000 | |
| GSE63941 | PCSK9 | 255738 | 227759_at | 1.0361 | 0.3315 | |
| GSE77861 | PCSK9 | 255738 | 227759_at | 0.1178 | 0.3936 | |
| GSE97050 | PCSK9 | 255738 | A_32_P142440 | 0.2198 | 0.3331 | |
| SRP007169 | PCSK9 | 255738 | RNAseq | 4.2049 | 0.0000 | |
| SRP008496 | PCSK9 | 255738 | RNAseq | 3.1792 | 0.0000 | |
| SRP064894 | PCSK9 | 255738 | RNAseq | 2.4338 | 0.0000 | |
| SRP133303 | PCSK9 | 255738 | RNAseq | 2.8414 | 0.0000 | |
| SRP159526 | PCSK9 | 255738 | RNAseq | 4.1577 | 0.0000 | |
| SRP193095 | PCSK9 | 255738 | RNAseq | 1.8119 | 0.0000 | |
| TCGA | PCSK9 | 255738 | RNAseq | 1.7225 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by PCSK9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK9 | 255738 | 3 | 4 | 23 | |
| GSE20123 | PCSK9 | 255738 | 3 | 3 | 24 | |
| GSE43470 | PCSK9 | 255738 | 8 | 1 | 34 | |
| GSE46452 | PCSK9 | 255738 | 2 | 1 | 56 | |
| GSE47630 | PCSK9 | 255738 | 8 | 4 | 28 | |
| GSE54993 | PCSK9 | 255738 | 0 | 0 | 70 | |
| GSE54994 | PCSK9 | 255738 | 10 | 2 | 41 | |
| GSE60625 | PCSK9 | 255738 | 0 | 0 | 11 | |
| GSE74703 | PCSK9 | 255738 | 6 | 1 | 29 | |
| GSE74704 | PCSK9 | 255738 | 2 | 0 | 18 | |
| TCGA | PCSK9 | 255738 | 10 | 19 | 67 |
Total number of gains: 52; Total number of losses: 35; Total Number of normals: 401.
Somatic mutations of PCSK9:
Generating mutation plots.
Highly correlated genes for PCSK9:
Showing top 20/559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK9 | ETV3 | 0.779473 | 3 | 0 | 3 |
| PCSK9 | ORC6 | 0.73654 | 5 | 0 | 5 |
| PCSK9 | NCAPG2 | 0.717328 | 3 | 0 | 3 |
| PCSK9 | IGF2BP2 | 0.704287 | 4 | 0 | 4 |
| PCSK9 | LHX1 | 0.700933 | 3 | 0 | 3 |
| PCSK9 | AUNIP | 0.699033 | 5 | 0 | 4 |
| PCSK9 | ERCC6L | 0.69805 | 4 | 0 | 4 |
| PCSK9 | CDC6 | 0.695415 | 5 | 0 | 5 |
| PCSK9 | NUDT1 | 0.690985 | 5 | 0 | 5 |
| PCSK9 | CENPN | 0.687807 | 5 | 0 | 5 |
| PCSK9 | MELK | 0.68732 | 4 | 0 | 4 |
| PCSK9 | NCAPH | 0.677553 | 4 | 0 | 4 |
| PCSK9 | MCM4 | 0.67752 | 4 | 0 | 4 |
| PCSK9 | DDIAS | 0.675009 | 4 | 0 | 4 |
| PCSK9 | LRR1 | 0.674803 | 6 | 0 | 5 |
| PCSK9 | ZNF114 | 0.674449 | 4 | 0 | 4 |
| PCSK9 | DEPDC1B | 0.674018 | 6 | 0 | 6 |
| PCSK9 | CHEK1 | 0.673828 | 5 | 0 | 5 |
| PCSK9 | AJUBA | 0.670048 | 4 | 0 | 4 |
| PCSK9 | POPDC3 | 0.667815 | 3 | 0 | 3 |
For details and further investigation, click here
