| Full name: MyoD family inhibitor domain containing | Alias Symbol: HIC|MDFIC1 | ||
| Type: protein-coding gene | Cytoband: 7q31.1-q31.2 | ||
| Entrez ID: 29969 | HGNC ID: HGNC:28870 | Ensembl Gene: ENSG00000135272 | OMIM ID: 614511 |
| Drug and gene relationship at DGIdb | |||
Expression of MDFIC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDFIC | 29969 | 211675_s_at | -0.5933 | 0.0506 | |
| GSE20347 | MDFIC | 29969 | 211675_s_at | -0.8915 | 0.0002 | |
| GSE23400 | MDFIC | 29969 | 211675_s_at | -0.4564 | 0.0000 | |
| GSE26886 | MDFIC | 29969 | 211675_s_at | -1.0100 | 0.0021 | |
| GSE29001 | MDFIC | 29969 | 211675_s_at | -0.6844 | 0.1865 | |
| GSE38129 | MDFIC | 29969 | 211675_s_at | -0.6880 | 0.0002 | |
| GSE45670 | MDFIC | 29969 | 211675_s_at | -0.4996 | 0.0025 | |
| GSE53622 | MDFIC | 29969 | 61645 | -0.7129 | 0.0000 | |
| GSE53624 | MDFIC | 29969 | 61645 | -0.8245 | 0.0000 | |
| GSE63941 | MDFIC | 29969 | 211675_s_at | -3.3645 | 0.0096 | |
| GSE77861 | MDFIC | 29969 | 211675_s_at | -0.5563 | 0.1694 | |
| GSE97050 | MDFIC | 29969 | A_23_P327022 | -0.2364 | 0.2827 | |
| SRP007169 | MDFIC | 29969 | RNAseq | -1.9400 | 0.0000 | |
| SRP008496 | MDFIC | 29969 | RNAseq | -1.7940 | 0.0000 | |
| SRP064894 | MDFIC | 29969 | RNAseq | -0.4417 | 0.0513 | |
| SRP133303 | MDFIC | 29969 | RNAseq | -0.1591 | 0.4087 | |
| SRP159526 | MDFIC | 29969 | RNAseq | -0.9211 | 0.0003 | |
| SRP193095 | MDFIC | 29969 | RNAseq | -0.5894 | 0.0002 | |
| SRP219564 | MDFIC | 29969 | RNAseq | -0.7602 | 0.0642 | |
| TCGA | MDFIC | 29969 | RNAseq | 0.0962 | 0.1311 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MDFIC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDFIC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDFIC | 29969 | 10 | 2 | 18 | |
| GSE20123 | MDFIC | 29969 | 11 | 2 | 17 | |
| GSE43470 | MDFIC | 29969 | 3 | 2 | 38 | |
| GSE46452 | MDFIC | 29969 | 8 | 1 | 50 | |
| GSE47630 | MDFIC | 29969 | 7 | 4 | 29 | |
| GSE54993 | MDFIC | 29969 | 2 | 7 | 61 | |
| GSE54994 | MDFIC | 29969 | 11 | 5 | 37 | |
| GSE60625 | MDFIC | 29969 | 0 | 0 | 11 | |
| GSE74703 | MDFIC | 29969 | 3 | 2 | 31 | |
| GSE74704 | MDFIC | 29969 | 7 | 2 | 11 | |
| TCGA | MDFIC | 29969 | 34 | 17 | 45 |
Total number of gains: 96; Total number of losses: 44; Total Number of normals: 348.
Somatic mutations of MDFIC:
Generating mutation plots.
Highly correlated genes for MDFIC:
Showing top 20/1056 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDFIC | KDM3A | 0.746624 | 3 | 0 | 3 |
| MDFIC | RARS2 | 0.736395 | 3 | 0 | 3 |
| MDFIC | UBQLN1 | 0.730944 | 3 | 0 | 3 |
| MDFIC | MCTS1 | 0.72924 | 3 | 0 | 3 |
| MDFIC | ATP6V1G1 | 0.725806 | 3 | 0 | 3 |
| MDFIC | COPS4 | 0.723205 | 3 | 0 | 3 |
| MDFIC | THSD7A | 0.712748 | 3 | 0 | 3 |
| MDFIC | CLK4 | 0.708614 | 3 | 0 | 3 |
| MDFIC | SPIN4 | 0.707883 | 3 | 0 | 3 |
| MDFIC | RHOG | 0.707241 | 4 | 0 | 4 |
| MDFIC | PPP2R5E | 0.700283 | 3 | 0 | 3 |
| MDFIC | GOLGA5 | 0.700199 | 3 | 0 | 3 |
| MDFIC | TMEM218 | 0.695576 | 3 | 0 | 3 |
| MDFIC | SEC24D | 0.687204 | 3 | 0 | 3 |
| MDFIC | GTF2H5 | 0.683386 | 3 | 0 | 3 |
| MDFIC | GGA3 | 0.682343 | 3 | 0 | 3 |
| MDFIC | PLEKHA7 | 0.682193 | 6 | 0 | 5 |
| MDFIC | PPP2R3C | 0.681497 | 3 | 0 | 3 |
| MDFIC | MAML2 | 0.678628 | 3 | 0 | 3 |
| MDFIC | PPIL3 | 0.677882 | 3 | 0 | 3 |
For details and further investigation, click here
