GDF11

 

Full name: growth differentiation factor 11 Alias Symbol: BMP-11|BMP11
Type: protein-coding gene Cytoband: 12q13.2
Entrez ID: 10220 HGNC ID: HGNC:4216 Ensembl Gene: ENSG00000135414 OMIM ID: 603936
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of GDF11:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GDF11 10220 226232_at 0.2058 0.6567
GSE20347 GDF11 10220 216854_at 0.0700 0.4001
GSE23400 GDF11 10220 216860_s_at 0.0502 0.1689
GSE26886 GDF11 10220 216854_at 0.3132 0.0070
GSE29001 GDF11 10220 216860_s_at 0.1318 0.2394
GSE38129 GDF11 10220 216854_at -0.0124 0.8611
GSE45670 GDF11 10220 226232_at 0.0876 0.4855
GSE53622 GDF11 10220 35559 0.5122 0.0000
GSE53624 GDF11 10220 35559 0.5018 0.0000
GSE63941 GDF11 10220 226232_at -0.7787 0.0143
GSE77861 GDF11 10220 216854_at -0.0221 0.8632
GSE97050 GDF11 10220 A_23_P76102 0.3943 0.2151
SRP007169 GDF11 10220 RNAseq 2.3182 0.0006
SRP008496 GDF11 10220 RNAseq 2.2290 0.0001
SRP064894 GDF11 10220 RNAseq 0.8317 0.0000
SRP133303 GDF11 10220 RNAseq 0.4265 0.0706
SRP159526 GDF11 10220 RNAseq 1.0803 0.0119
SRP193095 GDF11 10220 RNAseq 0.7920 0.0000
SRP219564 GDF11 10220 RNAseq 0.1099 0.8297
TCGA GDF11 10220 RNAseq 0.2364 0.0501

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by GDF11 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GDF11:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GDF11 10220 6 1 23
GSE20123 GDF11 10220 6 1 23
GSE43470 GDF11 10220 4 0 39
GSE46452 GDF11 10220 8 1 50
GSE47630 GDF11 10220 10 2 28
GSE54993 GDF11 10220 0 5 65
GSE54994 GDF11 10220 4 1 48
GSE60625 GDF11 10220 0 0 11
GSE74703 GDF11 10220 4 0 32
GSE74704 GDF11 10220 4 1 15
TCGA GDF11 10220 15 10 71

Total number of gains: 61; Total number of losses: 22; Total Number of normals: 405.  

 

Somatic mutations of GDF11:

 

Generating mutation plots.

 

Highly correlated genes for GDF11:

 

Showing top 20/498 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GDF11DHDH0.823755303
GDF11TAS2R430.754562303
GDF11PLEKHA40.744635404
GDF11LIN370.73797303
GDF11TNFRSF90.735626303
GDF11PLXND10.732303
GDF11EFEMP20.730206303
GDF11MAST20.729494504
GDF11SLC39A130.720597404
GDF11RASGRP20.717603403
GDF11LRRC170.713909303
GDF11CD99L20.713379303
GDF11BRI30.712443303
GDF11COL6A20.712113404
GDF11CPT1C0.702739404
GDF11ZNF4690.701958404
GDF11C11orf960.701623303
GDF11TNFRSF1B0.698509303
GDF11SLC26A50.696328303
GDF11ZNF5740.690118404

For details and further investigation, click here