RB1

 

Full name: RB transcriptional corepressor 1 Alias Symbol: RB|PPP1R130
Type: protein-coding gene Cytoband: 13q14.2
Entrez ID: 5925 HGNC ID: HGNC:9884 Ensembl Gene: ENSG00000139687 OMIM ID: 614041
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

RB1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer

 

Expression of RB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RB1 5925 203132_at -0.0762 0.9371
GSE20347 RB1 5925 203132_at -0.0072 0.9784
GSE23400 RB1 5925 203132_at 0.4442 0.0013
GSE26886 RB1 5925 203132_at 0.2583 0.4032
GSE29001 RB1 5925 203132_at 0.1058 0.8059
GSE38129 RB1 5925 203132_at 0.1393 0.4402
GSE45670 RB1 5925 203132_at 0.3268 0.0798
GSE53622 RB1 5925 37614 0.2537 0.0042
GSE53624 RB1 5925 82136 -0.1838 0.0476
GSE63941 RB1 5925 203132_at -0.4516 0.7629
GSE77861 RB1 5925 203132_at 0.3988 0.1820
GSE97050 RB1 5925 A_23_P204850 0.1624 0.6965
SRP007169 RB1 5925 RNAseq -0.1443 0.6658
SRP008496 RB1 5925 RNAseq -0.1043 0.6408
SRP064894 RB1 5925 RNAseq -0.1563 0.6232
SRP133303 RB1 5925 RNAseq 0.1206 0.2526
SRP159526 RB1 5925 RNAseq -0.5537 0.1360
SRP193095 RB1 5925 RNAseq 0.0573 0.6761
SRP219564 RB1 5925 RNAseq -0.3333 0.5277
TCGA RB1 5925 RNAseq 0.1133 0.0897

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RB1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RB1 5925 1 13 16
GSE20123 RB1 5925 1 12 17
GSE43470 RB1 5925 3 13 27
GSE46452 RB1 5925 0 32 27
GSE47630 RB1 5925 2 27 11
GSE54993 RB1 5925 12 2 56
GSE54994 RB1 5925 1 17 35
GSE60625 RB1 5925 0 3 8
GSE74703 RB1 5925 3 10 23
GSE74704 RB1 5925 0 9 11
TCGA RB1 5925 8 42 46

Total number of gains: 31; Total number of losses: 180; Total Number of normals: 277.  

 

Somatic mutations of RB1:

 

Generating mutation plots.

 

Highly correlated genes for RB1:

 

Showing top 20/205 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RB1USP320.773944303
RB1ZNF700.765202303
RB1SNAP230.747505303
RB1WDR360.744955303
RB1SSU720.744485303
RB1HERPUD20.7396303
RB1EIF4E20.733221303
RB1SLC37A30.728284303
RB1LACTB0.727567303
RB1KBTBD60.723124303
RB1AMIGO20.717307303
RB1ELOVL70.715698404
RB1VANGL10.715425303
RB1IAH10.715267303
RB1TMCC30.709148303
RB1ERVW-10.707274303
RB1HOXA70.706875303
RB1DUS4L0.705458303
RB1DUSP180.700885403
RB1FLVCR10.700157303

For details and further investigation, click here