CUL1

 

Full name: cullin 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q36.1
Entrez ID: 8454 HGNC ID: HGNC:2551 Ensembl Gene: ENSG00000055130 OMIM ID: 603134
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 59/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CUL1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
hsa04710Circadian rhythm

 

Expression of CUL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CUL1 8454 207614_s_at -0.0294 0.9548
GSE20347 CUL1 8454 207614_s_at 0.2469 0.0910
GSE23400 CUL1 8454 207614_s_at 0.2250 0.0013
GSE26886 CUL1 8454 207614_s_at -0.5372 0.0617
GSE29001 CUL1 8454 207614_s_at 0.2480 0.6252
GSE38129 CUL1 8454 207614_s_at 0.2198 0.0481
GSE45670 CUL1 8454 207614_s_at 0.0269 0.8802
GSE53622 CUL1 8454 55468 0.2961 0.0000
GSE53624 CUL1 8454 55468 0.3473 0.0000
GSE63941 CUL1 8454 207614_s_at -0.1916 0.5376
GSE77861 CUL1 8454 207614_s_at 0.5595 0.0021
GSE97050 CUL1 8454 A_24_P303589 -0.0085 0.9811
SRP007169 CUL1 8454 RNAseq 0.8404 0.0164
SRP008496 CUL1 8454 RNAseq 0.6549 0.0020
SRP064894 CUL1 8454 RNAseq 0.2752 0.0274
SRP133303 CUL1 8454 RNAseq 0.2864 0.0202
SRP159526 CUL1 8454 RNAseq 0.0911 0.7189
SRP193095 CUL1 8454 RNAseq 0.0195 0.8218
SRP219564 CUL1 8454 RNAseq -0.3598 0.2213
TCGA CUL1 8454 RNAseq 0.0107 0.8169

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CUL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CUL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CUL1 8454 2 3 25
GSE20123 CUL1 8454 2 3 25
GSE43470 CUL1 8454 2 5 36
GSE46452 CUL1 8454 7 2 50
GSE47630 CUL1 8454 6 8 26
GSE54993 CUL1 8454 3 4 63
GSE54994 CUL1 8454 5 9 39
GSE60625 CUL1 8454 0 0 11
GSE74703 CUL1 8454 2 4 30
GSE74704 CUL1 8454 1 3 16
TCGA CUL1 8454 25 27 44

Total number of gains: 55; Total number of losses: 68; Total Number of normals: 365.  

 

Somatic mutations of CUL1:

 

Generating mutation plots.

 

Highly correlated genes for CUL1:

 

Showing top 20/784 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CUL1DLG50.80954303
CUL1ATL10.79357303
CUL1GOLIM40.76754303
CUL1SENP80.764904303
CUL1UFC10.760442303
CUL1SLC30A50.755718403
CUL1THAP50.755315404
CUL1SDHD0.749457303
CUL1UBE2N0.748541303
CUL1HEATR5A0.744443303
CUL1SPPL2A0.742137303
CUL1C6orf890.736933303
CUL1TSEN20.72761303
CUL1SERINC10.72248303
CUL1TMEM2050.722039404
CUL1RHEB0.72179213013
CUL1KLHL200.719462303
CUL1ZYG11B0.718862303
CUL1UNC45A0.717629303
CUL1GPHN0.71751303

For details and further investigation, click here