MMP1

 

Full name: matrix metallopeptidase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q22.2
Entrez ID: 4312 HGNC ID: HGNC:7155 Ensembl Gene: ENSG00000196611 OMIM ID: 120353
Drug and gene relationship at DGIdb

 

MMP1 involved pathways:

KEGG pathway Description View
hsa03320PPAR signaling pathway
hsa05200Pathways in cancer

 

Expression of MMP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MMP1 4312 204475_at 5.5519 0.0528
GSE20347 MMP1 4312 204475_at 5.3567 0.0000
GSE23400 MMP1 4312 204475_at 4.7689 0.0000
GSE26886 MMP1 4312 204475_at 7.1213 0.0000
GSE29001 MMP1 4312 204475_at 4.0606 0.0000
GSE38129 MMP1 4312 204475_at 5.5164 0.0000
GSE45670 MMP1 4312 204475_at 7.1497 0.0000
GSE53622 MMP1 4312 77815 4.5095 0.0000
GSE53624 MMP1 4312 77815 5.2184 0.0000
GSE63941 MMP1 4312 204475_at -4.6295 0.0637
GSE77861 MMP1 4312 204475_at 4.8913 0.0006
GSE97050 MMP1 4312 A_23_P1691 2.7139 0.0706
SRP007169 MMP1 4312 RNAseq 9.5760 0.0000
SRP008496 MMP1 4312 RNAseq 10.9359 0.0000
SRP064894 MMP1 4312 RNAseq 8.2118 0.0000
SRP133303 MMP1 4312 RNAseq 8.4124 0.0000
SRP159526 MMP1 4312 RNAseq 7.0175 0.0000
SRP193095 MMP1 4312 RNAseq 5.9125 0.0000
TCGA MMP1 4312 RNAseq 1.4977 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by MMP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MMP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MMP1 4312 5 8 17
GSE20123 MMP1 4312 5 8 17
GSE43470 MMP1 4312 5 5 33
GSE46452 MMP1 4312 5 24 30
GSE47630 MMP1 4312 2 19 19
GSE54993 MMP1 4312 9 2 59
GSE54994 MMP1 4312 6 18 29
GSE60625 MMP1 4312 0 3 8
GSE74703 MMP1 4312 3 4 29
GSE74704 MMP1 4312 5 4 11
TCGA MMP1 4312 10 44 42

Total number of gains: 55; Total number of losses: 139; Total Number of normals: 294.  

 

Somatic mutations of MMP1:

 

Generating mutation plots.

 

Highly correlated genes for MMP1:

 

Showing top 20/1653 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MMP1CTHRC10.85418808
MMP1WDR660.842654707
MMP1MMP30.82767713013
MMP1SPP10.81352811011
MMP1MMP120.81083113013
MMP1LAMC20.80674412011
MMP1PLAU0.7943213012
MMP1IGF2BP20.79180111011
MMP1C4orf480.790847707
MMP1MET0.78934211010
MMP1MFAP20.78835212011
MMP1CXCL80.78716610010
MMP1ADAMTS120.784307808
MMP1MMP110.78345909
MMP1TGFBI0.7806813012
MMP1FSCN10.77970612011
MMP1FOXD20.777776303
MMP1MRGBP0.776511009
MMP1COL5A20.77645313012
MMP1COL1A10.77644512011

For details and further investigation, click here