| Full name: RIC8 guanine nucleotide exchange factor B | Alias Symbol: FLJ10620|hSyn|RIC8 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 55188 | HGNC ID: HGNC:25555 | Ensembl Gene: ENSG00000111785 | OMIM ID: 609147 |
| Drug and gene relationship at DGIdb | |||
Expression of RIC8B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIC8B | 55188 | 219446_at | 0.3477 | 0.6133 | |
| GSE20347 | RIC8B | 55188 | 219446_at | 0.7037 | 0.0000 | |
| GSE23400 | RIC8B | 55188 | 219446_at | 0.4597 | 0.0000 | |
| GSE26886 | RIC8B | 55188 | 219446_at | 0.4768 | 0.0087 | |
| GSE29001 | RIC8B | 55188 | 219446_at | 0.7663 | 0.0008 | |
| GSE38129 | RIC8B | 55188 | 219446_at | 0.4330 | 0.0038 | |
| GSE45670 | RIC8B | 55188 | 219446_at | 0.3246 | 0.0515 | |
| GSE53622 | RIC8B | 55188 | 34938 | 0.3321 | 0.0006 | |
| GSE53624 | RIC8B | 55188 | 34938 | 0.4933 | 0.0000 | |
| GSE63941 | RIC8B | 55188 | 219446_at | 0.1365 | 0.6425 | |
| GSE77861 | RIC8B | 55188 | 229637_at | -0.0671 | 0.5614 | |
| GSE97050 | RIC8B | 55188 | A_33_P3362696 | -0.1607 | 0.6576 | |
| SRP007169 | RIC8B | 55188 | RNAseq | 1.9692 | 0.0000 | |
| SRP008496 | RIC8B | 55188 | RNAseq | 2.8969 | 0.0000 | |
| SRP064894 | RIC8B | 55188 | RNAseq | 0.6902 | 0.0000 | |
| SRP133303 | RIC8B | 55188 | RNAseq | 0.5282 | 0.0048 | |
| SRP159526 | RIC8B | 55188 | RNAseq | 1.2041 | 0.0000 | |
| SRP193095 | RIC8B | 55188 | RNAseq | 0.4299 | 0.0028 | |
| SRP219564 | RIC8B | 55188 | RNAseq | 0.3193 | 0.4639 | |
| TCGA | RIC8B | 55188 | RNAseq | -0.0437 | 0.4796 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by RIC8B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RIC8B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIC8B | 55188 | 5 | 3 | 22 | |
| GSE20123 | RIC8B | 55188 | 5 | 3 | 22 | |
| GSE43470 | RIC8B | 55188 | 2 | 1 | 40 | |
| GSE46452 | RIC8B | 55188 | 9 | 1 | 49 | |
| GSE47630 | RIC8B | 55188 | 9 | 1 | 30 | |
| GSE54993 | RIC8B | 55188 | 0 | 5 | 65 | |
| GSE54994 | RIC8B | 55188 | 4 | 2 | 47 | |
| GSE60625 | RIC8B | 55188 | 0 | 0 | 11 | |
| GSE74703 | RIC8B | 55188 | 2 | 0 | 34 | |
| GSE74704 | RIC8B | 55188 | 2 | 2 | 16 | |
| TCGA | RIC8B | 55188 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 28; Total Number of normals: 401.
Somatic mutations of RIC8B:
Generating mutation plots.
Highly correlated genes for RIC8B:
Showing top 20/948 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIC8B | LONRF3 | 0.747181 | 3 | 0 | 3 |
| RIC8B | PLXNB3 | 0.722208 | 3 | 0 | 3 |
| RIC8B | CERS2 | 0.713698 | 8 | 0 | 8 |
| RIC8B | ILDR2 | 0.707984 | 3 | 0 | 3 |
| RIC8B | HIBADH | 0.707301 | 5 | 0 | 5 |
| RIC8B | BOD1 | 0.698892 | 4 | 0 | 4 |
| RIC8B | ABCD4 | 0.696979 | 3 | 0 | 3 |
| RIC8B | CDKL3 | 0.685732 | 3 | 0 | 3 |
| RIC8B | PLEKHA3 | 0.682702 | 4 | 0 | 4 |
| RIC8B | TMEM143 | 0.681649 | 4 | 0 | 3 |
| RIC8B | SLC37A3 | 0.678813 | 3 | 0 | 3 |
| RIC8B | ZNF740 | 0.671123 | 3 | 0 | 3 |
| RIC8B | NF1 | 0.668748 | 3 | 0 | 3 |
| RIC8B | C1orf198 | 0.666811 | 5 | 0 | 5 |
| RIC8B | MON1A | 0.665078 | 3 | 0 | 3 |
| RIC8B | RASD2 | 0.665069 | 4 | 0 | 4 |
| RIC8B | CC2D2A | 0.665016 | 3 | 0 | 3 |
| RIC8B | ZIK1 | 0.660316 | 3 | 0 | 3 |
| RIC8B | P2RX4 | 0.653909 | 8 | 0 | 8 |
| RIC8B | ZNF704 | 0.653789 | 3 | 0 | 3 |
For details and further investigation, click here
