| Full name: purinergic receptor P2X 4 | Alias Symbol: P2X4 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 5025 | HGNC ID: HGNC:8535 | Ensembl Gene: ENSG00000135124 | OMIM ID: 600846 |
| Drug and gene relationship at DGIdb | |||
P2RX4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of P2RX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX4 | 5025 | 204088_at | 0.6206 | 0.2772 | |
| GSE20347 | P2RX4 | 5025 | 204088_at | 0.7264 | 0.0000 | |
| GSE23400 | P2RX4 | 5025 | 204088_at | 0.4807 | 0.0000 | |
| GSE26886 | P2RX4 | 5025 | 204088_at | 0.8833 | 0.0028 | |
| GSE29001 | P2RX4 | 5025 | 204088_at | 0.1803 | 0.1538 | |
| GSE38129 | P2RX4 | 5025 | 204088_at | 0.6457 | 0.0005 | |
| GSE45670 | P2RX4 | 5025 | 204088_at | 0.4091 | 0.1809 | |
| GSE53622 | P2RX4 | 5025 | 58645 | 0.5631 | 0.0000 | |
| GSE53624 | P2RX4 | 5025 | 94579 | 1.1127 | 0.0000 | |
| GSE63941 | P2RX4 | 5025 | 204088_at | 0.8636 | 0.0469 | |
| GSE77861 | P2RX4 | 5025 | 204088_at | 0.6818 | 0.0113 | |
| GSE97050 | P2RX4 | 5025 | A_33_P3362088 | 0.4142 | 0.2567 | |
| SRP007169 | P2RX4 | 5025 | RNAseq | 2.5282 | 0.0006 | |
| SRP008496 | P2RX4 | 5025 | RNAseq | 2.8683 | 0.0000 | |
| SRP064894 | P2RX4 | 5025 | RNAseq | 1.0349 | 0.0006 | |
| SRP133303 | P2RX4 | 5025 | RNAseq | 0.6927 | 0.0005 | |
| SRP159526 | P2RX4 | 5025 | RNAseq | 1.2148 | 0.0000 | |
| SRP193095 | P2RX4 | 5025 | RNAseq | 0.6138 | 0.0391 | |
| SRP219564 | P2RX4 | 5025 | RNAseq | 0.7733 | 0.0729 | |
| TCGA | P2RX4 | 5025 | RNAseq | -0.0373 | 0.6807 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by P2RX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX4 | 5025 | 6 | 3 | 21 | |
| GSE20123 | P2RX4 | 5025 | 6 | 3 | 21 | |
| GSE43470 | P2RX4 | 5025 | 2 | 2 | 39 | |
| GSE46452 | P2RX4 | 5025 | 9 | 1 | 49 | |
| GSE47630 | P2RX4 | 5025 | 9 | 3 | 28 | |
| GSE54993 | P2RX4 | 5025 | 0 | 5 | 65 | |
| GSE54994 | P2RX4 | 5025 | 6 | 7 | 40 | |
| GSE60625 | P2RX4 | 5025 | 0 | 0 | 11 | |
| GSE74703 | P2RX4 | 5025 | 2 | 1 | 33 | |
| GSE74704 | P2RX4 | 5025 | 3 | 2 | 15 | |
| TCGA | P2RX4 | 5025 | 21 | 10 | 65 |
Total number of gains: 64; Total number of losses: 37; Total Number of normals: 387.
Somatic mutations of P2RX4:
Generating mutation plots.
Highly correlated genes for P2RX4:
Showing top 20/1575 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX4 | PREX1 | 0.765859 | 3 | 0 | 3 |
| P2RX4 | KRTCAP2 | 0.745229 | 4 | 0 | 4 |
| P2RX4 | THUMPD2 | 0.728612 | 3 | 0 | 3 |
| P2RX4 | HIBADH | 0.725433 | 5 | 0 | 5 |
| P2RX4 | GRAMD1A | 0.720869 | 7 | 0 | 7 |
| P2RX4 | HPCAL1 | 0.715042 | 10 | 0 | 10 |
| P2RX4 | PDIA5 | 0.714934 | 3 | 0 | 3 |
| P2RX4 | NCKAP1L | 0.712901 | 3 | 0 | 3 |
| P2RX4 | TBC1D8B | 0.712669 | 3 | 0 | 3 |
| P2RX4 | TRIM47 | 0.711678 | 4 | 0 | 4 |
| P2RX4 | TIMP1 | 0.706888 | 11 | 0 | 10 |
| P2RX4 | MZT1 | 0.702553 | 3 | 0 | 3 |
| P2RX4 | GLIS2 | 0.69808 | 4 | 0 | 4 |
| P2RX4 | ZBED1 | 0.695706 | 5 | 0 | 4 |
| P2RX4 | ARPC1B | 0.69416 | 11 | 0 | 11 |
| P2RX4 | NOM1 | 0.6876 | 4 | 0 | 4 |
| P2RX4 | SLC35B2 | 0.687438 | 3 | 0 | 3 |
| P2RX4 | TMEM231 | 0.68689 | 3 | 0 | 3 |
| P2RX4 | HEXB | 0.686678 | 10 | 0 | 9 |
| P2RX4 | SDF4 | 0.685169 | 10 | 0 | 9 |
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