| Full name: microsomal glutathione S-transferase 1 | Alias Symbol: MGST-I | ||
| Type: protein-coding gene | Cytoband: 12p12.3 | ||
| Entrez ID: 4257 | HGNC ID: HGNC:7061 | Ensembl Gene: ENSG00000008394 | OMIM ID: 138330 |
| Drug and gene relationship at DGIdb | |||
Expression of MGST1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGST1 | 4257 | 224918_x_at | 0.6138 | 0.5716 | |
| GSE26886 | MGST1 | 4257 | 224918_x_at | 0.1406 | 0.8667 | |
| GSE45670 | MGST1 | 4257 | 224918_x_at | -0.5250 | 0.3201 | |
| GSE53622 | MGST1 | 4257 | 438 | -1.1516 | 0.0000 | |
| GSE53624 | MGST1 | 4257 | 438 | -0.5748 | 0.0064 | |
| GSE63941 | MGST1 | 4257 | 231736_x_at | -2.2254 | 0.4464 | |
| GSE77861 | MGST1 | 4257 | 231736_x_at | -0.2870 | 0.8384 | |
| GSE97050 | MGST1 | 4257 | A_23_P36658 | 0.1331 | 0.7706 | |
| SRP007169 | MGST1 | 4257 | RNAseq | -1.5850 | 0.1268 | |
| SRP064894 | MGST1 | 4257 | RNAseq | -0.4056 | 0.1759 | |
| SRP133303 | MGST1 | 4257 | RNAseq | -0.5488 | 0.3571 | |
| SRP159526 | MGST1 | 4257 | RNAseq | -0.4234 | 0.1975 | |
| SRP193095 | MGST1 | 4257 | RNAseq | -0.4285 | 0.1871 | |
| SRP219564 | MGST1 | 4257 | RNAseq | -0.4419 | 0.6724 | |
| TCGA | MGST1 | 4257 | RNAseq | -0.0537 | 0.7954 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MGST1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGST1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGST1 | 4257 | 7 | 2 | 21 | |
| GSE20123 | MGST1 | 4257 | 7 | 2 | 21 | |
| GSE43470 | MGST1 | 4257 | 8 | 4 | 31 | |
| GSE46452 | MGST1 | 4257 | 10 | 1 | 48 | |
| GSE47630 | MGST1 | 4257 | 14 | 1 | 25 | |
| GSE54993 | MGST1 | 4257 | 1 | 9 | 60 | |
| GSE54994 | MGST1 | 4257 | 11 | 2 | 40 | |
| GSE60625 | MGST1 | 4257 | 0 | 1 | 10 | |
| GSE74703 | MGST1 | 4257 | 8 | 3 | 25 | |
| GSE74704 | MGST1 | 4257 | 5 | 1 | 14 | |
| TCGA | MGST1 | 4257 | 41 | 5 | 50 |
Total number of gains: 112; Total number of losses: 31; Total Number of normals: 345.
Somatic mutations of MGST1:
Generating mutation plots.
Highly correlated genes for MGST1:
Showing top 20/32 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGST1 | RPP40 | 0.762811 | 3 | 0 | 3 |
| MGST1 | TLCD1 | 0.7037 | 3 | 0 | 3 |
| MGST1 | FAM89B | 0.697085 | 3 | 0 | 3 |
| MGST1 | NUP153 | 0.680563 | 3 | 0 | 3 |
| MGST1 | WNT5A | 0.674091 | 4 | 0 | 4 |
| MGST1 | RRP36 | 0.67223 | 3 | 0 | 3 |
| MGST1 | CYB5R1 | 0.6544 | 3 | 0 | 3 |
| MGST1 | XPO6 | 0.654316 | 3 | 0 | 3 |
| MGST1 | TMPRSS13 | 0.634732 | 3 | 0 | 3 |
| MGST1 | SLC10A3 | 0.63171 | 3 | 0 | 3 |
| MGST1 | CBLC | 0.622787 | 4 | 0 | 3 |
| MGST1 | MORC4 | 0.620045 | 3 | 0 | 3 |
| MGST1 | TXNDC9 | 0.609976 | 3 | 0 | 3 |
| MGST1 | PCYT1A | 0.608458 | 3 | 0 | 3 |
| MGST1 | PRKCI | 0.602145 | 3 | 0 | 3 |
| MGST1 | UBP1 | 0.599897 | 3 | 0 | 3 |
| MGST1 | GHR | 0.595606 | 3 | 0 | 3 |
| MGST1 | GALNT1 | 0.594115 | 5 | 0 | 3 |
| MGST1 | CDC42SE1 | 0.589473 | 3 | 0 | 3 |
| MGST1 | ABHD16A | 0.588445 | 3 | 0 | 3 |
For details and further investigation, click here
