| Full name: ribosomal protein S6 kinase A2 | Alias Symbol: RSK3|HU-2 | ||
| Type: protein-coding gene | Cytoband: 6q27 | ||
| Entrez ID: 6196 | HGNC ID: HGNC:10431 | Ensembl Gene: ENSG00000071242 | OMIM ID: 601685 |
| Drug and gene relationship at DGIdb | |||
RPS6KA2 involved pathways:
Expression of RPS6KA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KA2 | 6196 | 212912_at | -0.1923 | 0.8103 | |
| GSE20347 | RPS6KA2 | 6196 | 204906_at | -0.1326 | 0.3075 | |
| GSE23400 | RPS6KA2 | 6196 | 212912_at | -0.3004 | 0.0127 | |
| GSE26886 | RPS6KA2 | 6196 | 204906_at | -0.1773 | 0.5661 | |
| GSE29001 | RPS6KA2 | 6196 | 204906_at | -0.3046 | 0.3511 | |
| GSE38129 | RPS6KA2 | 6196 | 204906_at | -0.2949 | 0.0440 | |
| GSE45670 | RPS6KA2 | 6196 | 212912_at | -0.8992 | 0.0086 | |
| GSE53622 | RPS6KA2 | 6196 | 65455 | -0.7579 | 0.0000 | |
| GSE53624 | RPS6KA2 | 6196 | 4143 | -0.2060 | 0.0011 | |
| GSE63941 | RPS6KA2 | 6196 | 212912_at | -4.9538 | 0.0008 | |
| GSE77861 | RPS6KA2 | 6196 | 204906_at | -0.1793 | 0.1800 | |
| GSE97050 | RPS6KA2 | 6196 | A_33_P3399943 | -0.2004 | 0.5212 | |
| SRP007169 | RPS6KA2 | 6196 | RNAseq | -0.0893 | 0.8620 | |
| SRP008496 | RPS6KA2 | 6196 | RNAseq | -0.1277 | 0.7098 | |
| SRP064894 | RPS6KA2 | 6196 | RNAseq | -0.2355 | 0.4676 | |
| SRP133303 | RPS6KA2 | 6196 | RNAseq | -0.4589 | 0.0427 | |
| SRP159526 | RPS6KA2 | 6196 | RNAseq | -0.4513 | 0.1712 | |
| SRP193095 | RPS6KA2 | 6196 | RNAseq | 0.0314 | 0.8992 | |
| SRP219564 | RPS6KA2 | 6196 | RNAseq | -0.3885 | 0.4058 | |
| TCGA | RPS6KA2 | 6196 | RNAseq | -0.5458 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RPS6KA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KA2 | 6196 | 2 | 6 | 22 | |
| GSE20123 | RPS6KA2 | 6196 | 2 | 6 | 22 | |
| GSE43470 | RPS6KA2 | 6196 | 3 | 0 | 40 | |
| GSE46452 | RPS6KA2 | 6196 | 3 | 10 | 46 | |
| GSE47630 | RPS6KA2 | 6196 | 7 | 7 | 26 | |
| GSE54993 | RPS6KA2 | 6196 | 4 | 3 | 63 | |
| GSE54994 | RPS6KA2 | 6196 | 9 | 8 | 36 | |
| GSE60625 | RPS6KA2 | 6196 | 1 | 1 | 9 | |
| GSE74703 | RPS6KA2 | 6196 | 3 | 0 | 33 | |
| GSE74704 | RPS6KA2 | 6196 | 1 | 3 | 16 | |
| TCGA | RPS6KA2 | 6196 | 13 | 24 | 59 |
Total number of gains: 48; Total number of losses: 68; Total Number of normals: 372.
Somatic mutations of RPS6KA2:
Generating mutation plots.
Highly correlated genes for RPS6KA2:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KA2 | LINC01279 | 0.713563 | 3 | 0 | 3 |
| RPS6KA2 | MAGI2-AS3 | 0.707179 | 4 | 0 | 4 |
| RPS6KA2 | TMEM140 | 0.675624 | 3 | 0 | 3 |
| RPS6KA2 | LOXL3 | 0.670062 | 3 | 0 | 3 |
| RPS6KA2 | CCDC159 | 0.668897 | 4 | 0 | 4 |
| RPS6KA2 | CCDC80 | 0.665781 | 5 | 0 | 5 |
| RPS6KA2 | EEPD1 | 0.66451 | 4 | 0 | 3 |
| RPS6KA2 | TOX | 0.652085 | 7 | 0 | 6 |
| RPS6KA2 | GNG2 | 0.650557 | 4 | 0 | 4 |
| RPS6KA2 | ANKRD44 | 0.648472 | 6 | 0 | 5 |
| RPS6KA2 | ARHGEF6 | 0.647938 | 6 | 0 | 4 |
| RPS6KA2 | FXYD6 | 0.644742 | 7 | 0 | 6 |
| RPS6KA2 | SYNE1 | 0.644022 | 9 | 0 | 7 |
| RPS6KA2 | DDR2 | 0.642818 | 9 | 0 | 8 |
| RPS6KA2 | PRUNE2 | 0.642328 | 8 | 0 | 7 |
| RPS6KA2 | ZCCHC18 | 0.64224 | 4 | 0 | 4 |
| RPS6KA2 | HSD11B1 | 0.640213 | 5 | 0 | 4 |
| RPS6KA2 | SAMD11 | 0.639598 | 3 | 0 | 3 |
| RPS6KA2 | OXTR | 0.639538 | 3 | 0 | 3 |
| RPS6KA2 | LMOD1 | 0.639289 | 8 | 0 | 7 |
For details and further investigation, click here
