| Full name: spectrin beta, non-erythrocytic 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p16.2 | ||
| Entrez ID: 6711 | HGNC ID: HGNC:11275 | Ensembl Gene: ENSG00000115306 | OMIM ID: 182790 |
| Drug and gene relationship at DGIdb | |||
Expression of SPTBN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTBN1 | 6711 | 212071_s_at | -0.3306 | 0.6118 | |
| GSE20347 | SPTBN1 | 6711 | 212071_s_at | 0.2271 | 0.1204 | |
| GSE23400 | SPTBN1 | 6711 | 212071_s_at | -0.0870 | 0.4873 | |
| GSE26886 | SPTBN1 | 6711 | 212071_s_at | 0.5820 | 0.0263 | |
| GSE29001 | SPTBN1 | 6711 | 212071_s_at | 0.1537 | 0.7355 | |
| GSE38129 | SPTBN1 | 6711 | 212071_s_at | -0.2147 | 0.3812 | |
| GSE45670 | SPTBN1 | 6711 | 212071_s_at | -0.4768 | 0.0144 | |
| GSE53622 | SPTBN1 | 6711 | 3517 | -0.1055 | 0.4315 | |
| GSE53624 | SPTBN1 | 6711 | 3517 | 0.2507 | 0.0035 | |
| GSE63941 | SPTBN1 | 6711 | 212071_s_at | -1.3784 | 0.0163 | |
| GSE77861 | SPTBN1 | 6711 | 212071_s_at | 0.6159 | 0.0221 | |
| GSE97050 | SPTBN1 | 6711 | A_33_P3258467 | -0.6076 | 0.1866 | |
| SRP007169 | SPTBN1 | 6711 | RNAseq | 2.5724 | 0.0000 | |
| SRP008496 | SPTBN1 | 6711 | RNAseq | 2.4005 | 0.0000 | |
| SRP064894 | SPTBN1 | 6711 | RNAseq | 0.1225 | 0.5809 | |
| SRP133303 | SPTBN1 | 6711 | RNAseq | -0.0951 | 0.6386 | |
| SRP159526 | SPTBN1 | 6711 | RNAseq | 0.3402 | 0.2306 | |
| SRP193095 | SPTBN1 | 6711 | RNAseq | 0.4129 | 0.0326 | |
| SRP219564 | SPTBN1 | 6711 | RNAseq | 0.1256 | 0.8159 | |
| TCGA | SPTBN1 | 6711 | RNAseq | -0.2793 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SPTBN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTBN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTBN1 | 6711 | 10 | 0 | 20 | |
| GSE20123 | SPTBN1 | 6711 | 9 | 0 | 21 | |
| GSE43470 | SPTBN1 | 6711 | 5 | 0 | 38 | |
| GSE46452 | SPTBN1 | 6711 | 2 | 3 | 54 | |
| GSE47630 | SPTBN1 | 6711 | 8 | 0 | 32 | |
| GSE54993 | SPTBN1 | 6711 | 0 | 5 | 65 | |
| GSE54994 | SPTBN1 | 6711 | 12 | 0 | 41 | |
| GSE60625 | SPTBN1 | 6711 | 0 | 3 | 8 | |
| GSE74703 | SPTBN1 | 6711 | 5 | 0 | 31 | |
| GSE74704 | SPTBN1 | 6711 | 9 | 0 | 11 | |
| TCGA | SPTBN1 | 6711 | 36 | 2 | 58 |
Total number of gains: 96; Total number of losses: 13; Total Number of normals: 379.
Somatic mutations of SPTBN1:
Generating mutation plots.
Highly correlated genes for SPTBN1:
Showing top 20/1025 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTBN1 | SNX18 | 0.778574 | 3 | 0 | 3 |
| SPTBN1 | KLHL13 | 0.776893 | 4 | 0 | 4 |
| SPTBN1 | UBR1 | 0.775087 | 5 | 0 | 5 |
| SPTBN1 | SUPT7L | 0.771254 | 5 | 0 | 5 |
| SPTBN1 | SMCR8 | 0.768238 | 3 | 0 | 3 |
| SPTBN1 | NEDD1 | 0.76722 | 3 | 0 | 3 |
| SPTBN1 | ATIC | 0.756967 | 3 | 0 | 3 |
| SPTBN1 | SSRP1 | 0.753248 | 3 | 0 | 3 |
| SPTBN1 | CYP20A1 | 0.748635 | 3 | 0 | 3 |
| SPTBN1 | SOCS4 | 0.744664 | 3 | 0 | 3 |
| SPTBN1 | WDR54 | 0.743571 | 3 | 0 | 3 |
| SPTBN1 | PRDX2 | 0.742923 | 3 | 0 | 3 |
| SPTBN1 | THAP10 | 0.73893 | 4 | 0 | 4 |
| SPTBN1 | ERVFRD-1 | 0.736451 | 3 | 0 | 3 |
| SPTBN1 | SLC39A1 | 0.734745 | 3 | 0 | 3 |
| SPTBN1 | HAGH | 0.733996 | 3 | 0 | 3 |
| SPTBN1 | SMS | 0.732927 | 3 | 0 | 3 |
| SPTBN1 | MEF2A | 0.727148 | 4 | 0 | 3 |
| SPTBN1 | RPS6KA3 | 0.723002 | 3 | 0 | 3 |
| SPTBN1 | MED22 | 0.721074 | 3 | 0 | 3 |
For details and further investigation, click here
