| Full name: SPO11 initiator of meiotic double stranded breaks | Alias Symbol: CT35|SPATA43|TOPVIA | ||
| Type: protein-coding gene | Cytoband: 20q13.31 | ||
| Entrez ID: 23626 | HGNC ID: HGNC:11250 | Ensembl Gene: ENSG00000054796 | OMIM ID: 605114 |
| Drug and gene relationship at DGIdb | |||
Expression of SPO11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPO11 | 23626 | 222259_s_at | 0.0875 | 0.6689 | |
| GSE20347 | SPO11 | 23626 | 222259_s_at | 0.0177 | 0.7327 | |
| GSE23400 | SPO11 | 23626 | 222259_s_at | -0.0535 | 0.0145 | |
| GSE26886 | SPO11 | 23626 | 222259_s_at | 0.0563 | 0.5004 | |
| GSE29001 | SPO11 | 23626 | 222259_s_at | -0.0829 | 0.5335 | |
| GSE38129 | SPO11 | 23626 | 222259_s_at | -0.0096 | 0.8412 | |
| GSE45670 | SPO11 | 23626 | 222259_s_at | 0.0575 | 0.3638 | |
| GSE53622 | SPO11 | 23626 | 97841 | 0.0209 | 0.8680 | |
| GSE53624 | SPO11 | 23626 | 97841 | -0.0211 | 0.8015 | |
| GSE63941 | SPO11 | 23626 | 222259_s_at | 0.1192 | 0.2892 | |
| GSE77861 | SPO11 | 23626 | 222259_s_at | 0.0447 | 0.5654 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPO11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPO11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPO11 | 23626 | 14 | 2 | 14 | |
| GSE20123 | SPO11 | 23626 | 14 | 2 | 14 | |
| GSE43470 | SPO11 | 23626 | 13 | 0 | 30 | |
| GSE46452 | SPO11 | 23626 | 29 | 0 | 30 | |
| GSE47630 | SPO11 | 23626 | 24 | 1 | 15 | |
| GSE54993 | SPO11 | 23626 | 0 | 18 | 52 | |
| GSE54994 | SPO11 | 23626 | 29 | 0 | 24 | |
| GSE60625 | SPO11 | 23626 | 0 | 0 | 11 | |
| GSE74703 | SPO11 | 23626 | 11 | 0 | 25 | |
| GSE74704 | SPO11 | 23626 | 11 | 0 | 9 | |
| TCGA | SPO11 | 23626 | 43 | 5 | 48 |
Total number of gains: 188; Total number of losses: 28; Total Number of normals: 272.
Somatic mutations of SPO11:
Generating mutation plots.
Highly correlated genes for SPO11:
Showing top 20/162 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPO11 | FGF20 | 0.705171 | 3 | 0 | 3 |
| SPO11 | MAS1 | 0.682655 | 3 | 0 | 3 |
| SPO11 | RPS6KA6 | 0.675822 | 3 | 0 | 3 |
| SPO11 | CYP7A1 | 0.665333 | 3 | 0 | 3 |
| SPO11 | CCDC30 | 0.661831 | 3 | 0 | 3 |
| SPO11 | PSG9 | 0.65083 | 3 | 0 | 3 |
| SPO11 | NR2E3 | 0.646572 | 3 | 0 | 3 |
| SPO11 | ARHGEF38 | 0.645046 | 3 | 0 | 3 |
| SPO11 | EPN1 | 0.637328 | 3 | 0 | 3 |
| SPO11 | SCG3 | 0.625919 | 3 | 0 | 3 |
| SPO11 | OR10C1 | 0.618534 | 4 | 0 | 3 |
| SPO11 | MTAP | 0.617382 | 3 | 0 | 3 |
| SPO11 | MTNR1B | 0.615672 | 3 | 0 | 3 |
| SPO11 | IFNA4 | 0.610284 | 4 | 0 | 3 |
| SPO11 | GNG13 | 0.609542 | 4 | 0 | 3 |
| SPO11 | OCM2 | 0.6095 | 3 | 0 | 3 |
| SPO11 | APCS | 0.609079 | 3 | 0 | 3 |
| SPO11 | DPF3 | 0.608198 | 4 | 0 | 3 |
| SPO11 | PEX5L | 0.607162 | 5 | 0 | 3 |
| SPO11 | IQCH | 0.604374 | 3 | 0 | 3 |
For details and further investigation, click here
