| Full name: collagen type IV alpha 1 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 1282 | HGNC ID: HGNC:2202 | Ensembl Gene: ENSG00000187498 | OMIM ID: 120130 |
| Drug and gene relationship at DGIdb | |||
COL4A1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of COL4A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL4A1 | 1282 | 211980_at | 0.9045 | 0.2308 | |
| GSE20347 | COL4A1 | 1282 | 211980_at | 2.1897 | 0.0000 | |
| GSE23400 | COL4A1 | 1282 | 211980_at | 1.2315 | 0.0000 | |
| GSE26886 | COL4A1 | 1282 | 211980_at | 3.3348 | 0.0000 | |
| GSE29001 | COL4A1 | 1282 | 211980_at | 1.8655 | 0.0005 | |
| GSE38129 | COL4A1 | 1282 | 211980_at | 1.6413 | 0.0000 | |
| GSE45670 | COL4A1 | 1282 | 211980_at | 0.8505 | 0.1158 | |
| GSE53622 | COL4A1 | 1282 | 55408 | 1.5866 | 0.0000 | |
| GSE53624 | COL4A1 | 1282 | 55408 | 1.1492 | 0.0000 | |
| GSE63941 | COL4A1 | 1282 | 211980_at | -3.6132 | 0.0321 | |
| GSE77861 | COL4A1 | 1282 | 211980_at | 2.8274 | 0.0015 | |
| GSE97050 | COL4A1 | 1282 | A_23_P65240 | 0.8356 | 0.1203 | |
| SRP007169 | COL4A1 | 1282 | RNAseq | 4.4881 | 0.0000 | |
| SRP008496 | COL4A1 | 1282 | RNAseq | 4.5687 | 0.0000 | |
| SRP064894 | COL4A1 | 1282 | RNAseq | 2.1543 | 0.0000 | |
| SRP133303 | COL4A1 | 1282 | RNAseq | 1.7366 | 0.0000 | |
| SRP159526 | COL4A1 | 1282 | RNAseq | 1.9761 | 0.0000 | |
| SRP193095 | COL4A1 | 1282 | RNAseq | 3.3412 | 0.0000 | |
| SRP219564 | COL4A1 | 1282 | RNAseq | 0.7141 | 0.2522 | |
| TCGA | COL4A1 | 1282 | RNAseq | 0.1683 | 0.0249 |
Upregulated datasets: 14; Downregulated datasets: 1.
Survival by COL4A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL4A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL4A1 | 1282 | 7 | 11 | 12 | |
| GSE20123 | COL4A1 | 1282 | 7 | 10 | 13 | |
| GSE43470 | COL4A1 | 1282 | 4 | 13 | 26 | |
| GSE46452 | COL4A1 | 1282 | 2 | 31 | 26 | |
| GSE47630 | COL4A1 | 1282 | 3 | 26 | 11 | |
| GSE54993 | COL4A1 | 1282 | 11 | 4 | 55 | |
| GSE54994 | COL4A1 | 1282 | 8 | 8 | 37 | |
| GSE60625 | COL4A1 | 1282 | 0 | 3 | 8 | |
| GSE74703 | COL4A1 | 1282 | 3 | 9 | 24 | |
| GSE74704 | COL4A1 | 1282 | 5 | 9 | 6 | |
| TCGA | COL4A1 | 1282 | 19 | 33 | 44 |
Total number of gains: 69; Total number of losses: 157; Total Number of normals: 262.
Somatic mutations of COL4A1:
Generating mutation plots.
Highly correlated genes for COL4A1:
Showing top 20/1868 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL4A1 | COL4A2 | 0.89443 | 13 | 0 | 13 |
| COL4A1 | CALU | 0.81347 | 12 | 0 | 12 |
| COL4A1 | PXDN | 0.801519 | 13 | 0 | 12 |
| COL4A1 | CD276 | 0.796611 | 4 | 0 | 4 |
| COL4A1 | FAM126A | 0.794791 | 3 | 0 | 3 |
| COL4A1 | ENAH | 0.785498 | 12 | 0 | 12 |
| COL4A1 | VCAN | 0.78341 | 13 | 0 | 11 |
| COL4A1 | CEP120 | 0.782907 | 3 | 0 | 3 |
| COL4A1 | SPARC | 0.78177 | 13 | 0 | 13 |
| COL4A1 | WDR81 | 0.779699 | 3 | 0 | 3 |
| COL4A1 | FNDC3B | 0.775788 | 12 | 0 | 11 |
| COL4A1 | LGALS1 | 0.770244 | 12 | 0 | 11 |
| COL4A1 | COL5A1 | 0.766282 | 13 | 0 | 13 |
| COL4A1 | PLOD3 | 0.765914 | 12 | 0 | 12 |
| COL4A1 | LAMB1 | 0.762904 | 13 | 0 | 13 |
| COL4A1 | LOXL2 | 0.758257 | 12 | 0 | 11 |
| COL4A1 | SLC19A1 | 0.758106 | 3 | 0 | 3 |
| COL4A1 | COL5A2 | 0.757738 | 13 | 0 | 12 |
| COL4A1 | COL1A2 | 0.757297 | 13 | 0 | 13 |
| COL4A1 | LPCAT1 | 0.757148 | 11 | 0 | 11 |
For details and further investigation, click here
