MTBP

 

Full name: MDM2 binding protein Alias Symbol: 
Type: protein-coding gene Cytoband: 8q24.12
Entrez ID: 27085 HGNC ID: HGNC:7417 Ensembl Gene: ENSG00000172167 OMIM ID: 605927
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MTBP:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MTBP 27085 1552518_s_at 0.9862 0.0512
GSE26886 MTBP 27085 233211_at -0.0036 0.9715
GSE45670 MTBP 27085 233436_at 1.1144 0.0000
GSE53622 MTBP 27085 19097 1.7699 0.0000
GSE53624 MTBP 27085 11276 1.9559 0.0000
GSE63941 MTBP 27085 233211_at 0.6737 0.0017
GSE77861 MTBP 27085 233211_at -0.0310 0.7260
GSE97050 MTBP 27085 A_23_P357794 0.3419 0.2000
SRP007169 MTBP 27085 RNAseq 2.3596 0.0000
SRP008496 MTBP 27085 RNAseq 2.0614 0.0000
SRP064894 MTBP 27085 RNAseq 1.6481 0.0000
SRP133303 MTBP 27085 RNAseq 1.3417 0.0000
SRP159526 MTBP 27085 RNAseq 1.2782 0.0000
SRP193095 MTBP 27085 RNAseq 1.3351 0.0000
SRP219564 MTBP 27085 RNAseq 1.3408 0.0004
TCGA MTBP 27085 RNAseq 0.9921 0.0000

Upregulated datasets: 10; Downregulated datasets: 0.  

 

Survival by MTBP expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MTBP:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MTBP 27085 19 1 10
GSE20123 MTBP 27085 20 1 9
GSE43470 MTBP 27085 23 0 20
GSE46452 MTBP 27085 27 0 32
GSE47630 MTBP 27085 24 0 16
GSE54993 MTBP 27085 0 20 50
GSE54994 MTBP 27085 38 0 15
GSE60625 MTBP 27085 0 4 7
GSE74703 MTBP 27085 19 0 17
GSE74704 MTBP 27085 13 1 6
TCGA MTBP 27085 66 3 27

Total number of gains: 249; Total number of losses: 30; Total Number of normals: 209.  

 

Somatic mutations of MTBP:

 

Generating mutation plots.

 

Highly correlated genes for MTBP:

 

Showing top 20/1486 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MTBPRPN10.834553505
MTBPLRRC580.826304303
MTBPPLXNA10.820989505
MTBPPRKDC0.820719505
MTBPATP2C10.816751505
MTBPLRP80.810483303
MTBPATAD20.80698707
MTBPDNAJB110.797642505
MTBPPYCR20.789967303
MTBPTAF20.787846606
MTBPTBC1D310.7877504
MTBPMMS22L0.787107303
MTBPWDR540.78489404
MTBPKHSRP0.779502303
MTBPGTSE10.775212505
MTBPPFDN20.774732505
MTBPPTRH20.77427505
MTBPBLM0.77186606
MTBPTMEM1380.770777505
MTBPTTK0.76302606

For details and further investigation, click here