| Full name: plakophilin 4 | Alias Symbol: p0071 | ||
| Type: protein-coding gene | Cytoband: 2q24.1 | ||
| Entrez ID: 8502 | HGNC ID: HGNC:9026 | Ensembl Gene: ENSG00000144283 | OMIM ID: 604276 |
| Drug and gene relationship at DGIdb | |||
Expression of PKP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKP4 | 8502 | 201928_at | 0.3679 | 0.4263 | |
| GSE20347 | PKP4 | 8502 | 201928_at | 0.0556 | 0.6911 | |
| GSE23400 | PKP4 | 8502 | 201929_s_at | 0.1878 | 0.0089 | |
| GSE26886 | PKP4 | 8502 | 201928_at | 0.0960 | 0.7022 | |
| GSE29001 | PKP4 | 8502 | 201928_at | 0.1207 | 0.5834 | |
| GSE38129 | PKP4 | 8502 | 201928_at | 0.0649 | 0.6329 | |
| GSE45670 | PKP4 | 8502 | 201928_at | -0.0357 | 0.8524 | |
| GSE53622 | PKP4 | 8502 | 69160 | -0.1625 | 0.0315 | |
| GSE53624 | PKP4 | 8502 | 69160 | 0.0038 | 0.9474 | |
| GSE63941 | PKP4 | 8502 | 201928_at | 0.5149 | 0.0869 | |
| GSE77861 | PKP4 | 8502 | 201928_at | 0.0411 | 0.8508 | |
| GSE97050 | PKP4 | 8502 | A_33_P3288110 | -0.4218 | 0.3067 | |
| SRP007169 | PKP4 | 8502 | RNAseq | -0.3148 | 0.4553 | |
| SRP008496 | PKP4 | 8502 | RNAseq | -0.0763 | 0.7428 | |
| SRP064894 | PKP4 | 8502 | RNAseq | -0.0837 | 0.5052 | |
| SRP133303 | PKP4 | 8502 | RNAseq | -0.1894 | 0.1723 | |
| SRP159526 | PKP4 | 8502 | RNAseq | 0.0196 | 0.9260 | |
| SRP193095 | PKP4 | 8502 | RNAseq | -0.0826 | 0.3481 | |
| SRP219564 | PKP4 | 8502 | RNAseq | -0.3730 | 0.3553 | |
| TCGA | PKP4 | 8502 | RNAseq | 0.0008 | 0.9865 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PKP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKP4 | 8502 | 5 | 1 | 24 | |
| GSE20123 | PKP4 | 8502 | 5 | 1 | 24 | |
| GSE43470 | PKP4 | 8502 | 4 | 1 | 38 | |
| GSE46452 | PKP4 | 8502 | 1 | 4 | 54 | |
| GSE47630 | PKP4 | 8502 | 5 | 3 | 32 | |
| GSE54993 | PKP4 | 8502 | 0 | 4 | 66 | |
| GSE54994 | PKP4 | 8502 | 11 | 2 | 40 | |
| GSE60625 | PKP4 | 8502 | 0 | 3 | 8 | |
| GSE74703 | PKP4 | 8502 | 3 | 1 | 32 | |
| GSE74704 | PKP4 | 8502 | 3 | 0 | 17 | |
| TCGA | PKP4 | 8502 | 24 | 12 | 60 |
Total number of gains: 61; Total number of losses: 32; Total Number of normals: 395.
Somatic mutations of PKP4:
Generating mutation plots.
Highly correlated genes for PKP4:
Showing top 20/165 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKP4 | NUFIP2 | 0.812742 | 3 | 0 | 3 |
| PKP4 | RRS1 | 0.759418 | 3 | 0 | 3 |
| PKP4 | KRTCAP2 | 0.75518 | 3 | 0 | 3 |
| PKP4 | IWS1 | 0.752542 | 3 | 0 | 3 |
| PKP4 | ZNF830 | 0.740398 | 3 | 0 | 3 |
| PKP4 | METAP1D | 0.739399 | 3 | 0 | 3 |
| PKP4 | NUFIP1 | 0.732825 | 3 | 0 | 3 |
| PKP4 | LPGAT1 | 0.698212 | 3 | 0 | 3 |
| PKP4 | CENPL | 0.69317 | 3 | 0 | 3 |
| PKP4 | INSR | 0.690153 | 3 | 0 | 3 |
| PKP4 | BZW2 | 0.689764 | 3 | 0 | 3 |
| PKP4 | ZNF140 | 0.685709 | 4 | 0 | 4 |
| PKP4 | MED1 | 0.682025 | 3 | 0 | 3 |
| PKP4 | CCDC14 | 0.677619 | 3 | 0 | 3 |
| PKP4 | DCAF16 | 0.675424 | 4 | 0 | 3 |
| PKP4 | ZFP62 | 0.671854 | 3 | 0 | 3 |
| PKP4 | EPPK1 | 0.669973 | 3 | 0 | 3 |
| PKP4 | RBM17 | 0.668847 | 4 | 0 | 3 |
| PKP4 | NR2C2 | 0.668845 | 4 | 0 | 3 |
| PKP4 | TUBGCP3 | 0.665552 | 4 | 0 | 3 |
For details and further investigation, click here
