| Full name: stearoyl-CoA desaturase | Alias Symbol: FADS5 | ||
| Type: protein-coding gene | Cytoband: 10q24.31 | ||
| Entrez ID: 6319 | HGNC ID: HGNC:10571 | Ensembl Gene: ENSG00000099194 | OMIM ID: 604031 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SCD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04152 | AMPK signaling pathway |
Expression of SCD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCD | 6319 | 200832_s_at | 1.2345 | 0.2494 | |
| GSE20347 | SCD | 6319 | 200832_s_at | 0.4123 | 0.1598 | |
| GSE23400 | SCD | 6319 | 200832_s_at | 0.2947 | 0.1031 | |
| GSE26886 | SCD | 6319 | 200832_s_at | -1.4320 | 0.0068 | |
| GSE29001 | SCD | 6319 | 200832_s_at | 0.2153 | 0.6211 | |
| GSE38129 | SCD | 6319 | 200832_s_at | 0.7392 | 0.0115 | |
| GSE45670 | SCD | 6319 | 200832_s_at | 0.6832 | 0.0220 | |
| GSE63941 | SCD | 6319 | 200832_s_at | 0.4972 | 0.5515 | |
| GSE77861 | SCD | 6319 | 200832_s_at | -0.1267 | 0.7208 | |
| GSE97050 | SCD | 6319 | A_32_P163858 | 0.2011 | 0.5209 | |
| SRP007169 | SCD | 6319 | RNAseq | 0.2871 | 0.4885 | |
| SRP008496 | SCD | 6319 | RNAseq | -0.2439 | 0.5312 | |
| SRP064894 | SCD | 6319 | RNAseq | 0.1461 | 0.6045 | |
| SRP133303 | SCD | 6319 | RNAseq | 0.7417 | 0.0899 | |
| SRP159526 | SCD | 6319 | RNAseq | 1.4709 | 0.0009 | |
| SRP193095 | SCD | 6319 | RNAseq | 0.4323 | 0.0589 | |
| SRP219564 | SCD | 6319 | RNAseq | 1.1475 | 0.0810 | |
| TCGA | SCD | 6319 | RNAseq | 0.4904 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SCD expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SCD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCD | 6319 | 1 | 8 | 21 | |
| GSE20123 | SCD | 6319 | 1 | 7 | 22 | |
| GSE43470 | SCD | 6319 | 0 | 7 | 36 | |
| GSE46452 | SCD | 6319 | 0 | 11 | 48 | |
| GSE47630 | SCD | 6319 | 2 | 14 | 24 | |
| GSE54993 | SCD | 6319 | 8 | 0 | 62 | |
| GSE54994 | SCD | 6319 | 1 | 14 | 38 | |
| GSE60625 | SCD | 6319 | 0 | 0 | 11 | |
| GSE74703 | SCD | 6319 | 0 | 5 | 31 | |
| GSE74704 | SCD | 6319 | 0 | 4 | 16 | |
| TCGA | SCD | 6319 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 98; Total Number of normals: 372.
Somatic mutations of SCD:
Generating mutation plots.
Highly correlated genes for SCD:
Showing top 20/166 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCD | YWHAE | 0.738271 | 3 | 0 | 3 |
| SCD | FAM49B | 0.717735 | 3 | 0 | 3 |
| SCD | EAF1 | 0.717163 | 3 | 0 | 3 |
| SCD | CMIP | 0.707359 | 3 | 0 | 3 |
| SCD | PTPN13 | 0.70102 | 3 | 0 | 3 |
| SCD | RPP40 | 0.695539 | 3 | 0 | 3 |
| SCD | IPMK | 0.693772 | 3 | 0 | 3 |
| SCD | PPP4R2 | 0.692646 | 3 | 0 | 3 |
| SCD | TYW5 | 0.690469 | 3 | 0 | 3 |
| SCD | DPP9 | 0.688494 | 3 | 0 | 3 |
| SCD | UBE2F | 0.68381 | 3 | 0 | 3 |
| SCD | SNRNP200 | 0.681488 | 3 | 0 | 3 |
| SCD | CYB5RL | 0.681266 | 3 | 0 | 3 |
| SCD | FAM83H | 0.67787 | 4 | 0 | 3 |
| SCD | MTHFD2 | 0.676991 | 3 | 0 | 3 |
| SCD | LACTB | 0.676561 | 3 | 0 | 3 |
| SCD | COX16 | 0.675514 | 4 | 0 | 3 |
| SCD | MRPS22 | 0.669756 | 3 | 0 | 3 |
| SCD | FDPS | 0.666927 | 7 | 0 | 6 |
| SCD | TBC1D22A | 0.666383 | 3 | 0 | 3 |
For details and further investigation, click here
