MTHFD2

 

Full name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Alias Symbol: 
Type: protein-coding gene Cytoband: 2p13.1
Entrez ID: 10797 HGNC ID: HGNC:7434 Ensembl Gene: ENSG00000065911 OMIM ID: 604887
Drug and gene relationship at DGIdb

 

Expression of MTHFD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MTHFD2 10797 201761_at 0.7961 0.0642
GSE20347 MTHFD2 10797 201761_at 1.8965 0.0000
GSE23400 MTHFD2 10797 201761_at 1.6474 0.0000
GSE26886 MTHFD2 10797 201761_at 0.7220 0.0075
GSE29001 MTHFD2 10797 201761_at 1.3688 0.0002
GSE38129 MTHFD2 10797 201761_at 1.8757 0.0000
GSE45670 MTHFD2 10797 201761_at 1.0299 0.0002
GSE53622 MTHFD2 10797 31277 1.2919 0.0000
GSE53624 MTHFD2 10797 31277 1.3455 0.0000
GSE63941 MTHFD2 10797 201761_at 1.3201 0.0289
GSE77861 MTHFD2 10797 201761_at 1.7799 0.0007
GSE97050 MTHFD2 10797 A_23_P120316 1.2487 0.0647
SRP007169 MTHFD2 10797 RNAseq 2.4460 0.0000
SRP008496 MTHFD2 10797 RNAseq 1.8015 0.0000
SRP064894 MTHFD2 10797 RNAseq 0.9282 0.0002
SRP133303 MTHFD2 10797 RNAseq 1.6674 0.0000
SRP159526 MTHFD2 10797 RNAseq 1.3448 0.0000
SRP193095 MTHFD2 10797 RNAseq 1.0512 0.0000
SRP219564 MTHFD2 10797 RNAseq 0.5614 0.1410
TCGA MTHFD2 10797 RNAseq 0.1945 0.0012

Upregulated datasets: 14; Downregulated datasets: 0.  

 

Survival by MTHFD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MTHFD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MTHFD2 10797 10 1 19
GSE20123 MTHFD2 10797 11 1 18
GSE43470 MTHFD2 10797 4 0 39
GSE46452 MTHFD2 10797 2 3 54
GSE47630 MTHFD2 10797 7 0 33
GSE54993 MTHFD2 10797 0 6 64
GSE54994 MTHFD2 10797 10 0 43
GSE60625 MTHFD2 10797 0 3 8
GSE74703 MTHFD2 10797 4 0 32
GSE74704 MTHFD2 10797 8 0 12
TCGA MTHFD2 10797 38 2 56

Total number of gains: 94; Total number of losses: 16; Total Number of normals: 378.  

 

Somatic mutations of MTHFD2:

 

Generating mutation plots.

 

Highly correlated genes for MTHFD2:

 

Showing top 20/1979 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MTHFD2MCM60.8134611011
MTHFD2PYCR20.795842303
MTHFD2XPOT0.79407811011
MTHFD2DNMT10.78563611011
MTHFD2NCAPG20.78169410010
MTHFD2PSME40.78162411011
MTHFD2KPNA20.780046909
MTHFD2DKC10.776284303
MTHFD2CBX30.77507110010
MTHFD2MCM40.77476111011
MTHFD2NEK20.77362311010
MTHFD2TRIP130.7727211011
MTHFD2CDCA20.771127505
MTHFD2KNTC10.77015810010
MTHFD2FZD60.770081808
MTHFD2FEN10.769475808
MTHFD2GINS10.7694211011
MTHFD2ECT20.76756212010
MTHFD2CCT50.766253807
MTHFD2AURKA0.76424712011

For details and further investigation, click here