| Full name: succinate dehydrogenase complex assembly factor 1 | Alias Symbol: LYRM8 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 644096 | HGNC ID: HGNC:33867 | Ensembl Gene: ENSG00000205138 | OMIM ID: 612848 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SDHAF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHAF1 | 644096 | 221855_at | 0.0788 | 0.7931 | |
| GSE20347 | SDHAF1 | 644096 | 221855_at | 0.0919 | 0.3941 | |
| GSE23400 | SDHAF1 | 644096 | 221855_at | 0.0176 | 0.6921 | |
| GSE26886 | SDHAF1 | 644096 | 221855_at | 0.6772 | 0.0000 | |
| GSE29001 | SDHAF1 | 644096 | 221855_at | 0.1315 | 0.4811 | |
| GSE38129 | SDHAF1 | 644096 | 221855_at | 0.0932 | 0.3460 | |
| GSE45670 | SDHAF1 | 644096 | 221855_at | -0.0045 | 0.9817 | |
| GSE53622 | SDHAF1 | 644096 | 76933 | -0.1005 | 0.2103 | |
| GSE53624 | SDHAF1 | 644096 | 76933 | 0.2076 | 0.0070 | |
| GSE63941 | SDHAF1 | 644096 | 221855_at | 0.5725 | 0.1638 | |
| GSE77861 | SDHAF1 | 644096 | 221855_at | 0.1382 | 0.4336 | |
| GSE97050 | SDHAF1 | 644096 | A_32_P23010 | -0.0634 | 0.8439 | |
| SRP007169 | SDHAF1 | 644096 | RNAseq | 0.7756 | 0.2108 | |
| SRP008496 | SDHAF1 | 644096 | RNAseq | 0.4262 | 0.3310 | |
| SRP064894 | SDHAF1 | 644096 | RNAseq | 0.7468 | 0.0472 | |
| SRP133303 | SDHAF1 | 644096 | RNAseq | 0.0647 | 0.7712 | |
| SRP159526 | SDHAF1 | 644096 | RNAseq | 0.2065 | 0.3037 | |
| SRP193095 | SDHAF1 | 644096 | RNAseq | -0.0517 | 0.6805 | |
| SRP219564 | SDHAF1 | 644096 | RNAseq | 0.2127 | 0.4871 | |
| TCGA | SDHAF1 | 644096 | RNAseq | 0.0188 | 0.7996 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SDHAF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHAF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHAF1 | 644096 | 7 | 4 | 19 | |
| GSE20123 | SDHAF1 | 644096 | 7 | 3 | 20 | |
| GSE43470 | SDHAF1 | 644096 | 3 | 7 | 33 | |
| GSE46452 | SDHAF1 | 644096 | 48 | 1 | 10 | |
| GSE47630 | SDHAF1 | 644096 | 9 | 5 | 26 | |
| GSE54993 | SDHAF1 | 644096 | 17 | 3 | 50 | |
| GSE54994 | SDHAF1 | 644096 | 6 | 9 | 38 | |
| GSE60625 | SDHAF1 | 644096 | 9 | 0 | 2 | |
| GSE74703 | SDHAF1 | 644096 | 3 | 4 | 29 | |
| GSE74704 | SDHAF1 | 644096 | 6 | 1 | 13 | |
| TCGA | SDHAF1 | 644096 | 22 | 10 | 64 |
Total number of gains: 137; Total number of losses: 47; Total Number of normals: 304.
Somatic mutations of SDHAF1:
Generating mutation plots.
Highly correlated genes for SDHAF1:
Showing top 20/191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHAF1 | CXorf56 | 0.73258 | 3 | 0 | 3 |
| SDHAF1 | SCUBE1 | 0.715554 | 3 | 0 | 3 |
| SDHAF1 | ASMTL | 0.713971 | 3 | 0 | 3 |
| SDHAF1 | SDCCAG8 | 0.705204 | 3 | 0 | 3 |
| SDHAF1 | PRRT2 | 0.700872 | 3 | 0 | 3 |
| SDHAF1 | PCP2 | 0.68318 | 3 | 0 | 3 |
| SDHAF1 | TLR8 | 0.679098 | 3 | 0 | 3 |
| SDHAF1 | DUSP9 | 0.676232 | 4 | 0 | 3 |
| SDHAF1 | PPP1R12C | 0.67015 | 3 | 0 | 3 |
| SDHAF1 | GALNS | 0.66886 | 3 | 0 | 3 |
| SDHAF1 | TIGD5 | 0.662279 | 3 | 0 | 3 |
| SDHAF1 | SDK1 | 0.652323 | 4 | 0 | 3 |
| SDHAF1 | CRYBB3 | 0.648817 | 4 | 0 | 3 |
| SDHAF1 | IFT27 | 0.644451 | 4 | 0 | 3 |
| SDHAF1 | SPATA2L | 0.644267 | 5 | 0 | 4 |
| SDHAF1 | RBM42 | 0.639603 | 12 | 0 | 11 |
| SDHAF1 | TOE1 | 0.639153 | 4 | 0 | 3 |
| SDHAF1 | CTNS | 0.637739 | 5 | 0 | 4 |
| SDHAF1 | MRPL28 | 0.637679 | 3 | 0 | 3 |
| SDHAF1 | CDH2 | 0.63633 | 4 | 0 | 3 |
For details and further investigation, click here
