MRPL28

 

Full name: mitochondrial ribosomal protein L28 Alias Symbol: p15
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 10573 HGNC ID: HGNC:14484 Ensembl Gene: ENSG00000086504 OMIM ID: 604853
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MRPL28:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MRPL28 10573 204599_s_at 0.2319 0.5495
GSE20347 MRPL28 10573 204599_s_at 0.3983 0.0007
GSE23400 MRPL28 10573 204599_s_at 0.1994 0.0004
GSE26886 MRPL28 10573 204599_s_at 0.3739 0.0047
GSE29001 MRPL28 10573 204599_s_at 0.4520 0.1629
GSE38129 MRPL28 10573 204599_s_at 0.3980 0.0001
GSE45670 MRPL28 10573 204599_s_at 0.4441 0.0006
GSE53622 MRPL28 10573 89362 0.4625 0.0000
GSE53624 MRPL28 10573 89362 0.5380 0.0000
GSE63941 MRPL28 10573 204599_s_at -0.2912 0.3132
GSE77861 MRPL28 10573 204599_s_at 0.1663 0.2618
GSE97050 MRPL28 10573 A_23_P129513 0.3719 0.1927
SRP007169 MRPL28 10573 RNAseq 0.3870 0.2092
SRP008496 MRPL28 10573 RNAseq 0.2725 0.2062
SRP064894 MRPL28 10573 RNAseq 0.8546 0.0093
SRP133303 MRPL28 10573 RNAseq 0.5028 0.0003
SRP159526 MRPL28 10573 RNAseq 0.4537 0.1024
SRP193095 MRPL28 10573 RNAseq 0.2922 0.0190
SRP219564 MRPL28 10573 RNAseq 0.6008 0.0841
TCGA MRPL28 10573 RNAseq 0.1821 0.0024

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MRPL28 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MRPL28:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MRPL28 10573 5 5 20
GSE20123 MRPL28 10573 5 4 21
GSE43470 MRPL28 10573 3 7 33
GSE46452 MRPL28 10573 38 1 20
GSE47630 MRPL28 10573 13 6 21
GSE54993 MRPL28 10573 3 5 62
GSE54994 MRPL28 10573 4 10 39
GSE60625 MRPL28 10573 4 0 7
GSE74703 MRPL28 10573 3 5 28
GSE74704 MRPL28 10573 3 2 15
TCGA MRPL28 10573 20 15 61

Total number of gains: 101; Total number of losses: 60; Total Number of normals: 327.  

 

Somatic mutations of MRPL28:

 

Generating mutation plots.

 

Highly correlated genes for MRPL28:

 

Showing top 20/722 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MRPL28POC1A0.710537404
MRPL28MRPS340.7035991009
MRPL28POLR3K0.6961310010
MRPL28TANGO60.684313505
MRPL28TSR30.68207811010
MRPL28SDC40.68069303
MRPL28DCTPP10.67997111010
MRPL28FBXO220.674707404
MRPL28TRAF70.660805403
MRPL28DDIAS0.659137303
MRPL28PSMA70.657353909
MRPL28CHTF180.656618504
MRPL28EME10.6496504
MRPL28NUDT10.64737910010
MRPL28NTMT10.645543707
MRPL28IFT430.645369505
MRPL28UBL7-AS10.644999505
MRPL28NLN0.6449404
MRPL28C16orf910.644532706
MRPL28DTYMK0.643636909

For details and further investigation, click here