| Full name: cystinosin, lysosomal cystine transporter | Alias Symbol: CTNS-LSB|PQLC4|SLC66A4 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 1497 | HGNC ID: HGNC:2518 | Ensembl Gene: ENSG00000040531 | OMIM ID: 606272 |
| Drug and gene relationship at DGIdb | |||
Expression of CTNS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTNS | 1497 | 204925_at | 0.4934 | 0.1811 | |
| GSE20347 | CTNS | 1497 | 36566_at | 0.5881 | 0.0001 | |
| GSE23400 | CTNS | 1497 | 36566_at | 0.2660 | 0.0000 | |
| GSE26886 | CTNS | 1497 | 204925_at | 0.9422 | 0.0000 | |
| GSE29001 | CTNS | 1497 | 36566_at | 0.3660 | 0.0575 | |
| GSE38129 | CTNS | 1497 | 36566_at | 0.5387 | 0.0000 | |
| GSE45670 | CTNS | 1497 | 36566_at | 0.4145 | 0.0212 | |
| GSE63941 | CTNS | 1497 | 36566_at | -0.9617 | 0.0788 | |
| GSE77861 | CTNS | 1497 | 36566_at | 0.2310 | 0.2029 | |
| GSE97050 | CTNS | 1497 | A_33_P3322430 | 0.2280 | 0.3646 | |
| SRP007169 | CTNS | 1497 | RNAseq | 1.3210 | 0.0081 | |
| SRP008496 | CTNS | 1497 | RNAseq | 1.7610 | 0.0000 | |
| SRP064894 | CTNS | 1497 | RNAseq | 0.8923 | 0.0000 | |
| SRP133303 | CTNS | 1497 | RNAseq | 0.1831 | 0.1456 | |
| SRP159526 | CTNS | 1497 | RNAseq | 0.6727 | 0.0014 | |
| SRP193095 | CTNS | 1497 | RNAseq | 0.6203 | 0.0000 | |
| SRP219564 | CTNS | 1497 | RNAseq | 1.1123 | 0.0528 | |
| TCGA | CTNS | 1497 | RNAseq | -0.1918 | 0.0021 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by CTNS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CTNS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTNS | 1497 | 5 | 3 | 22 | |
| GSE20123 | CTNS | 1497 | 5 | 4 | 21 | |
| GSE43470 | CTNS | 1497 | 1 | 6 | 36 | |
| GSE46452 | CTNS | 1497 | 34 | 1 | 24 | |
| GSE47630 | CTNS | 1497 | 7 | 1 | 32 | |
| GSE54993 | CTNS | 1497 | 4 | 3 | 63 | |
| GSE54994 | CTNS | 1497 | 5 | 9 | 39 | |
| GSE60625 | CTNS | 1497 | 4 | 0 | 7 | |
| GSE74703 | CTNS | 1497 | 1 | 3 | 32 | |
| GSE74704 | CTNS | 1497 | 3 | 2 | 15 | |
| TCGA | CTNS | 1497 | 17 | 21 | 58 |
Total number of gains: 86; Total number of losses: 53; Total Number of normals: 349.
Somatic mutations of CTNS:
Generating mutation plots.
Highly correlated genes for CTNS:
Showing top 20/445 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTNS | TNK1 | 0.770226 | 3 | 0 | 3 |
| CTNS | SH3PXD2B | 0.720686 | 3 | 0 | 3 |
| CTNS | RRP36 | 0.705405 | 3 | 0 | 3 |
| CTNS | B3GALT6 | 0.704542 | 3 | 0 | 3 |
| CTNS | ADAMTS2 | 0.680318 | 4 | 0 | 4 |
| CTNS | PLBD2 | 0.671455 | 5 | 0 | 5 |
| CTNS | PSMA7 | 0.669993 | 5 | 0 | 5 |
| CTNS | CMSS1 | 0.668932 | 3 | 0 | 3 |
| CTNS | C4orf46 | 0.659002 | 3 | 0 | 3 |
| CTNS | SCYL1 | 0.657833 | 3 | 0 | 3 |
| CTNS | NEU1 | 0.657348 | 6 | 0 | 6 |
| CTNS | FBLIM1 | 0.650774 | 4 | 0 | 3 |
| CTNS | MRGBP | 0.650006 | 8 | 0 | 7 |
| CTNS | PEX16 | 0.649253 | 3 | 0 | 3 |
| CTNS | ABCC10 | 0.648905 | 4 | 0 | 3 |
| CTNS | TENM2 | 0.645129 | 3 | 0 | 3 |
| CTNS | LRP12 | 0.644253 | 6 | 0 | 6 |
| CTNS | FADS3 | 0.64415 | 6 | 0 | 4 |
| CTNS | MFAP2 | 0.643424 | 7 | 0 | 6 |
| CTNS | COA7 | 0.641747 | 4 | 0 | 4 |
For details and further investigation, click here
