| Full name: succinate dehydrogenase complex subunit C | Alias Symbol: CYB560|cybL | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 6391 | HGNC ID: HGNC:10682 | Ensembl Gene: ENSG00000143252 | OMIM ID: 602413 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SDHC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHC | 6391 | 210131_x_at | 0.0974 | 0.8057 | |
| GSE20347 | SDHC | 6391 | 215088_s_at | -0.2601 | 0.0087 | |
| GSE23400 | SDHC | 6391 | 202004_x_at | -0.0054 | 0.9272 | |
| GSE26886 | SDHC | 6391 | 215088_s_at | -0.8270 | 0.0003 | |
| GSE29001 | SDHC | 6391 | 215088_s_at | -0.0823 | 0.8313 | |
| GSE38129 | SDHC | 6391 | 215088_s_at | 0.0044 | 0.9729 | |
| GSE45670 | SDHC | 6391 | 202004_x_at | -0.0365 | 0.7738 | |
| GSE53622 | SDHC | 6391 | 85082 | -0.1562 | 0.0015 | |
| GSE53624 | SDHC | 6391 | 52761 | -0.2076 | 0.0000 | |
| GSE63941 | SDHC | 6391 | 210131_x_at | 0.1532 | 0.7101 | |
| GSE77861 | SDHC | 6391 | 215088_s_at | -0.1395 | 0.4379 | |
| GSE97050 | SDHC | 6391 | A_24_P233850 | -0.5136 | 0.1498 | |
| SRP007169 | SDHC | 6391 | RNAseq | -1.0180 | 0.0099 | |
| SRP008496 | SDHC | 6391 | RNAseq | -0.8787 | 0.0000 | |
| SRP064894 | SDHC | 6391 | RNAseq | -0.2908 | 0.0629 | |
| SRP133303 | SDHC | 6391 | RNAseq | -0.1281 | 0.3700 | |
| SRP159526 | SDHC | 6391 | RNAseq | 0.2723 | 0.2278 | |
| SRP193095 | SDHC | 6391 | RNAseq | -0.3726 | 0.0016 | |
| SRP219564 | SDHC | 6391 | RNAseq | -0.2648 | 0.2783 | |
| TCGA | SDHC | 6391 | RNAseq | 0.0125 | 0.7979 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SDHC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHC | 6391 | 11 | 0 | 19 | |
| GSE20123 | SDHC | 6391 | 11 | 0 | 19 | |
| GSE43470 | SDHC | 6391 | 7 | 2 | 34 | |
| GSE46452 | SDHC | 6391 | 2 | 1 | 56 | |
| GSE47630 | SDHC | 6391 | 14 | 0 | 26 | |
| GSE54993 | SDHC | 6391 | 0 | 5 | 65 | |
| GSE54994 | SDHC | 6391 | 16 | 0 | 37 | |
| GSE60625 | SDHC | 6391 | 0 | 0 | 11 | |
| GSE74703 | SDHC | 6391 | 7 | 2 | 27 | |
| GSE74704 | SDHC | 6391 | 5 | 0 | 15 | |
| TCGA | SDHC | 6391 | 44 | 3 | 49 |
Total number of gains: 117; Total number of losses: 13; Total Number of normals: 358.
Somatic mutations of SDHC:
Generating mutation plots.
Highly correlated genes for SDHC:
Showing top 20/495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHC | GLOD4 | 0.830623 | 3 | 0 | 3 |
| SDHC | PHKB | 0.779714 | 3 | 0 | 3 |
| SDHC | PTGR1 | 0.757787 | 3 | 0 | 3 |
| SDHC | ZNF564 | 0.716792 | 3 | 0 | 3 |
| SDHC | NDUFA12 | 0.71511 | 3 | 0 | 3 |
| SDHC | SPAG16 | 0.715026 | 3 | 0 | 3 |
| SDHC | ZNF879 | 0.698404 | 3 | 0 | 3 |
| SDHC | RPS14 | 0.697457 | 4 | 0 | 4 |
| SDHC | DPY30 | 0.694051 | 3 | 0 | 3 |
| SDHC | AK3 | 0.690082 | 3 | 0 | 3 |
| SDHC | ESYT2 | 0.688658 | 3 | 0 | 3 |
| SDHC | AMBRA1 | 0.688092 | 3 | 0 | 3 |
| SDHC | LEPROT | 0.68698 | 3 | 0 | 3 |
| SDHC | ARHGAP17 | 0.684702 | 3 | 0 | 3 |
| SDHC | LAMTOR5 | 0.681757 | 3 | 0 | 3 |
| SDHC | SRRM1 | 0.680281 | 3 | 0 | 3 |
| SDHC | CAPNS2 | 0.678348 | 3 | 0 | 3 |
| SDHC | KBTBD8 | 0.67789 | 3 | 0 | 3 |
| SDHC | MLLT10 | 0.677437 | 3 | 0 | 3 |
| SDHC | CALCOCO2 | 0.676128 | 4 | 0 | 3 |
For details and further investigation, click here
