| Full name: phosphorylase kinase regulatory subunit beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16q12.1 | ||
| Entrez ID: 5257 | HGNC ID: HGNC:8927 | Ensembl Gene: ENSG00000102893 | OMIM ID: 172490 |
| Drug and gene relationship at DGIdb | |||
PHKB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04922 | Glucagon signaling pathway |
Expression of PHKB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHKB | 5257 | 202738_s_at | -0.2255 | 0.7491 | |
| GSE20347 | PHKB | 5257 | 202739_s_at | -0.4723 | 0.0001 | |
| GSE23400 | PHKB | 5257 | 202739_s_at | -0.3338 | 0.0000 | |
| GSE26886 | PHKB | 5257 | 202739_s_at | -1.1570 | 0.0000 | |
| GSE29001 | PHKB | 5257 | 202739_s_at | -0.4551 | 0.0700 | |
| GSE38129 | PHKB | 5257 | 202739_s_at | -0.4981 | 0.0002 | |
| GSE45670 | PHKB | 5257 | 202738_s_at | -0.3062 | 0.0269 | |
| GSE53622 | PHKB | 5257 | 26394 | -0.5225 | 0.0000 | |
| GSE53624 | PHKB | 5257 | 26394 | -0.7004 | 0.0000 | |
| GSE63941 | PHKB | 5257 | 202738_s_at | -0.2435 | 0.6428 | |
| GSE77861 | PHKB | 5257 | 202738_s_at | -0.3325 | 0.1449 | |
| GSE97050 | PHKB | 5257 | A_23_P206532 | -0.2666 | 0.2057 | |
| SRP007169 | PHKB | 5257 | RNAseq | -0.6450 | 0.0292 | |
| SRP008496 | PHKB | 5257 | RNAseq | -0.5244 | 0.0507 | |
| SRP064894 | PHKB | 5257 | RNAseq | -0.8225 | 0.0000 | |
| SRP133303 | PHKB | 5257 | RNAseq | -0.3170 | 0.0050 | |
| SRP159526 | PHKB | 5257 | RNAseq | -0.3450 | 0.1542 | |
| SRP193095 | PHKB | 5257 | RNAseq | -0.5145 | 0.0000 | |
| SRP219564 | PHKB | 5257 | RNAseq | -0.4443 | 0.2247 | |
| TCGA | PHKB | 5257 | RNAseq | -0.1695 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PHKB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHKB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHKB | 5257 | 2 | 1 | 27 | |
| GSE20123 | PHKB | 5257 | 2 | 1 | 27 | |
| GSE43470 | PHKB | 5257 | 2 | 7 | 34 | |
| GSE46452 | PHKB | 5257 | 38 | 1 | 20 | |
| GSE47630 | PHKB | 5257 | 11 | 7 | 22 | |
| GSE54993 | PHKB | 5257 | 2 | 5 | 63 | |
| GSE54994 | PHKB | 5257 | 6 | 10 | 37 | |
| GSE60625 | PHKB | 5257 | 4 | 0 | 7 | |
| GSE74703 | PHKB | 5257 | 2 | 4 | 30 | |
| GSE74704 | PHKB | 5257 | 2 | 1 | 17 | |
| TCGA | PHKB | 5257 | 28 | 13 | 55 |
Total number of gains: 99; Total number of losses: 50; Total Number of normals: 339.
Somatic mutations of PHKB:
Generating mutation plots.
Highly correlated genes for PHKB:
Showing top 20/1225 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHKB | UBE2D2 | 0.805054 | 4 | 0 | 4 |
| PHKB | GLYR1 | 0.801246 | 3 | 0 | 3 |
| PHKB | SDHC | 0.779714 | 3 | 0 | 3 |
| PHKB | SAMM50 | 0.763273 | 3 | 0 | 3 |
| PHKB | CWC25 | 0.759441 | 3 | 0 | 3 |
| PHKB | COMMD1 | 0.754741 | 4 | 0 | 4 |
| PHKB | RBM20 | 0.75326 | 4 | 0 | 4 |
| PHKB | HDAC3 | 0.752219 | 3 | 0 | 3 |
| PHKB | ATP6V1B2 | 0.745772 | 3 | 0 | 3 |
| PHKB | SNX12 | 0.738455 | 4 | 0 | 4 |
| PHKB | FAM98C | 0.734944 | 3 | 0 | 3 |
| PHKB | NFKB1 | 0.725868 | 3 | 0 | 3 |
| PHKB | TBC1D20 | 0.720259 | 4 | 0 | 4 |
| PHKB | ATP6V0D1 | 0.712007 | 6 | 0 | 5 |
| PHKB | PPP1R11 | 0.711103 | 3 | 0 | 3 |
| PHKB | CSNK2B | 0.709075 | 3 | 0 | 3 |
| PHKB | THAP2 | 0.707521 | 4 | 0 | 3 |
| PHKB | CCIN | 0.704855 | 4 | 0 | 3 |
| PHKB | FAM174A | 0.704055 | 5 | 0 | 4 |
| PHKB | MALT1 | 0.703819 | 4 | 0 | 4 |
For details and further investigation, click here
