| Full name: RNA polymerase III subunit B | Alias Symbol: RPC2|FLJ10388 | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 55703 | HGNC ID: HGNC:30348 | Ensembl Gene: ENSG00000013503 | OMIM ID: 614366 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR3B | 55703 | 219459_at | -0.1592 | 0.8893 | |
| GSE20347 | POLR3B | 55703 | 219459_at | -0.5533 | 0.0001 | |
| GSE23400 | POLR3B | 55703 | 219459_at | -0.3382 | 0.0000 | |
| GSE26886 | POLR3B | 55703 | 219459_at | -0.6152 | 0.0069 | |
| GSE29001 | POLR3B | 55703 | 219459_at | -0.7354 | 0.0073 | |
| GSE38129 | POLR3B | 55703 | 219459_at | -0.2633 | 0.1190 | |
| GSE45670 | POLR3B | 55703 | 219459_at | -0.2777 | 0.1636 | |
| GSE53622 | POLR3B | 55703 | 89404 | -0.3405 | 0.0010 | |
| GSE53624 | POLR3B | 55703 | 89404 | -0.5321 | 0.0000 | |
| GSE63941 | POLR3B | 55703 | 219459_at | -0.3515 | 0.2830 | |
| GSE77861 | POLR3B | 55703 | 219459_at | -0.8132 | 0.0414 | |
| GSE97050 | POLR3B | 55703 | A_24_P321626 | 0.2562 | 0.3649 | |
| SRP007169 | POLR3B | 55703 | RNAseq | -1.5408 | 0.0015 | |
| SRP008496 | POLR3B | 55703 | RNAseq | -1.2644 | 0.0000 | |
| SRP064894 | POLR3B | 55703 | RNAseq | -0.9015 | 0.0000 | |
| SRP133303 | POLR3B | 55703 | RNAseq | -0.4478 | 0.0171 | |
| SRP159526 | POLR3B | 55703 | RNAseq | -0.5021 | 0.0397 | |
| SRP193095 | POLR3B | 55703 | RNAseq | -0.5682 | 0.0000 | |
| SRP219564 | POLR3B | 55703 | RNAseq | -0.6479 | 0.0500 | |
| TCGA | POLR3B | 55703 | RNAseq | -0.0290 | 0.6463 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by POLR3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR3B | 55703 | 5 | 3 | 22 | |
| GSE20123 | POLR3B | 55703 | 5 | 3 | 22 | |
| GSE43470 | POLR3B | 55703 | 2 | 1 | 40 | |
| GSE46452 | POLR3B | 55703 | 9 | 1 | 49 | |
| GSE47630 | POLR3B | 55703 | 9 | 1 | 30 | |
| GSE54993 | POLR3B | 55703 | 0 | 5 | 65 | |
| GSE54994 | POLR3B | 55703 | 4 | 2 | 47 | |
| GSE60625 | POLR3B | 55703 | 0 | 0 | 11 | |
| GSE74703 | POLR3B | 55703 | 2 | 0 | 34 | |
| GSE74704 | POLR3B | 55703 | 2 | 2 | 16 | |
| TCGA | POLR3B | 55703 | 21 | 10 | 65 |
Total number of gains: 59; Total number of losses: 28; Total Number of normals: 401.
Somatic mutations of POLR3B:
Generating mutation plots.
Highly correlated genes for POLR3B:
Showing top 20/1190 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR3B | JADE3 | 0.723886 | 3 | 0 | 3 |
| POLR3B | WDR77 | 0.708046 | 3 | 0 | 3 |
| POLR3B | MIOS | 0.698562 | 11 | 0 | 10 |
| POLR3B | VSIG10L | 0.692908 | 4 | 0 | 4 |
| POLR3B | VTA1 | 0.692623 | 4 | 0 | 4 |
| POLR3B | MFSD5 | 0.6855 | 12 | 0 | 10 |
| POLR3B | MAPK13 | 0.684528 | 9 | 0 | 7 |
| POLR3B | UNC5CL | 0.68347 | 3 | 0 | 3 |
| POLR3B | SEC24C | 0.682272 | 9 | 0 | 9 |
| POLR3B | ZNRF1 | 0.681841 | 5 | 0 | 5 |
| POLR3B | ZNF823 | 0.677755 | 7 | 0 | 6 |
| POLR3B | PITHD1 | 0.676093 | 7 | 0 | 7 |
| POLR3B | TSPAN6 | 0.671963 | 10 | 0 | 9 |
| POLR3B | HEBP2 | 0.665015 | 10 | 0 | 10 |
| POLR3B | RASSF5 | 0.663475 | 7 | 0 | 6 |
| POLR3B | MACC1 | 0.663227 | 7 | 0 | 6 |
| POLR3B | ZFAND2B | 0.659756 | 6 | 0 | 6 |
| POLR3B | CTCF | 0.659518 | 3 | 0 | 3 |
| POLR3B | C12orf29 | 0.65839 | 10 | 0 | 10 |
| POLR3B | TET2 | 0.658365 | 6 | 0 | 5 |
For details and further investigation, click here
