TMX1

 

Full name: thioredoxin related transmembrane protein 1 Alias Symbol: TMX|PDIA11
Type: protein-coding gene Cytoband: 14q22.1
Entrez ID: 81542 HGNC ID: HGNC:15487 Ensembl Gene: ENSG00000139921 OMIM ID: 610527
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TMX1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMX1 81542 209476_at 0.4672 0.4002
GSE20347 TMX1 81542 209476_at 0.3629 0.0323
GSE23400 TMX1 81542 209476_at 0.8384 0.0000
GSE26886 TMX1 81542 209476_at 0.0517 0.8467
GSE29001 TMX1 81542 209476_at 0.7810 0.0170
GSE38129 TMX1 81542 209476_at 0.5210 0.0013
GSE45670 TMX1 81542 209476_at 0.6345 0.0000
GSE53622 TMX1 81542 133660 0.6459 0.0000
GSE53624 TMX1 81542 133660 0.6392 0.0000
GSE63941 TMX1 81542 209476_at -0.0974 0.7608
GSE77861 TMX1 81542 209476_at 0.0914 0.8464
GSE97050 TMX1 81542 A_23_P76951 0.6384 0.1581
SRP007169 TMX1 81542 RNAseq 0.4779 0.2291
SRP008496 TMX1 81542 RNAseq 0.4717 0.0495
SRP064894 TMX1 81542 RNAseq 0.8773 0.0000
SRP133303 TMX1 81542 RNAseq 0.7235 0.0009
SRP159526 TMX1 81542 RNAseq 0.1733 0.4243
SRP193095 TMX1 81542 RNAseq 0.1007 0.4855
SRP219564 TMX1 81542 RNAseq 0.6567 0.2190
TCGA TMX1 81542 RNAseq 0.1867 0.0003

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TMX1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMX1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMX1 81542 8 3 19
GSE20123 TMX1 81542 8 3 19
GSE43470 TMX1 81542 9 1 33
GSE46452 TMX1 81542 16 3 40
GSE47630 TMX1 81542 11 10 19
GSE54993 TMX1 81542 3 8 59
GSE54994 TMX1 81542 19 4 30
GSE60625 TMX1 81542 0 2 9
GSE74703 TMX1 81542 8 1 27
GSE74704 TMX1 81542 3 2 15
TCGA TMX1 81542 35 13 48

Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.  

 

Somatic mutations of TMX1:

 

Generating mutation plots.

 

Highly correlated genes for TMX1:

 

Showing top 20/1512 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMX1JKAMP0.767149807
TMX1EME10.766485303
TMX1ALG10.75718303
TMX1CENPBD10.737604303
TMX1TTC30B0.729833303
TMX1CKAP2L0.728218505
TMX1TDP10.72267410010
TMX1PSMA30.71512911010
TMX1LRRC580.714285303
TMX1MIS18BP10.713235605
TMX1B3GALT60.711053404
TMX1CDKN30.70677812011
TMX1CNIH10.70029111011
TMX1PIGM0.697961303
TMX1CENPL0.697005505
TMX1CDCA20.693939403
TMX1TOP1MT0.691258404
TMX1CCNA20.690612807
TMX1DLGAP50.68971812010
TMX1POLE20.68409511010

For details and further investigation, click here