| Full name: SEC61 translocon beta subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q22.33 | ||
| Entrez ID: 10952 | HGNC ID: HGNC:16993 | Ensembl Gene: ENSG00000106803 | OMIM ID: 609214 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC61B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC61B | 10952 | 203133_at | 0.1445 | 0.6433 | |
| GSE20347 | SEC61B | 10952 | 203133_at | -0.0440 | 0.7459 | |
| GSE23400 | SEC61B | 10952 | 203133_at | 0.2303 | 0.0003 | |
| GSE26886 | SEC61B | 10952 | 203133_at | -0.0898 | 0.4108 | |
| GSE29001 | SEC61B | 10952 | 203133_at | 0.0003 | 0.9987 | |
| GSE38129 | SEC61B | 10952 | 203133_at | 0.2055 | 0.0428 | |
| GSE45670 | SEC61B | 10952 | 203133_at | 0.1639 | 0.0998 | |
| GSE53622 | SEC61B | 10952 | 5804 | 0.2775 | 0.0000 | |
| GSE53624 | SEC61B | 10952 | 5804 | 0.4750 | 0.0000 | |
| GSE63941 | SEC61B | 10952 | 203133_at | -0.5888 | 0.1386 | |
| GSE77861 | SEC61B | 10952 | 203133_at | -0.0599 | 0.7864 | |
| GSE97050 | SEC61B | 10952 | A_24_P8494 | 0.4245 | 0.2152 | |
| SRP007169 | SEC61B | 10952 | RNAseq | -0.1833 | 0.6064 | |
| SRP008496 | SEC61B | 10952 | RNAseq | -0.3844 | 0.0947 | |
| SRP064894 | SEC61B | 10952 | RNAseq | 0.4733 | 0.0765 | |
| SRP133303 | SEC61B | 10952 | RNAseq | 0.2852 | 0.0800 | |
| SRP159526 | SEC61B | 10952 | RNAseq | 0.0679 | 0.7192 | |
| SRP193095 | SEC61B | 10952 | RNAseq | -0.3742 | 0.0112 | |
| SRP219564 | SEC61B | 10952 | RNAseq | 0.2612 | 0.2950 | |
| TCGA | SEC61B | 10952 | RNAseq | 0.0309 | 0.5883 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC61B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC61B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC61B | 10952 | 4 | 9 | 17 | |
| GSE20123 | SEC61B | 10952 | 4 | 8 | 18 | |
| GSE43470 | SEC61B | 10952 | 6 | 3 | 34 | |
| GSE46452 | SEC61B | 10952 | 6 | 13 | 40 | |
| GSE47630 | SEC61B | 10952 | 1 | 17 | 22 | |
| GSE54993 | SEC61B | 10952 | 3 | 3 | 64 | |
| GSE54994 | SEC61B | 10952 | 8 | 11 | 34 | |
| GSE60625 | SEC61B | 10952 | 0 | 0 | 11 | |
| GSE74703 | SEC61B | 10952 | 5 | 3 | 28 | |
| GSE74704 | SEC61B | 10952 | 2 | 5 | 13 | |
| TCGA | SEC61B | 10952 | 27 | 22 | 47 |
Total number of gains: 66; Total number of losses: 94; Total Number of normals: 328.
Somatic mutations of SEC61B:
Generating mutation plots.
Highly correlated genes for SEC61B:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC61B | C1orf56 | 0.788065 | 3 | 0 | 3 |
| SEC61B | KDM5B | 0.765513 | 3 | 0 | 3 |
| SEC61B | USP38 | 0.752738 | 3 | 0 | 3 |
| SEC61B | GPX1 | 0.726035 | 3 | 0 | 3 |
| SEC61B | ARPC4 | 0.712168 | 3 | 0 | 3 |
| SEC61B | TRAPPC2L | 0.71162 | 4 | 0 | 4 |
| SEC61B | EIF4E | 0.710082 | 3 | 0 | 3 |
| SEC61B | ABHD16B | 0.704359 | 3 | 0 | 3 |
| SEC61B | TPM3 | 0.703824 | 5 | 0 | 5 |
| SEC61B | BZW1 | 0.70043 | 4 | 0 | 3 |
| SEC61B | BPNT1 | 0.698591 | 3 | 0 | 3 |
| SEC61B | TRAPPC6B | 0.691216 | 3 | 0 | 3 |
| SEC61B | SCAMP3 | 0.68931 | 7 | 0 | 7 |
| SEC61B | CLSPN | 0.685367 | 4 | 0 | 4 |
| SEC61B | ARHGAP31 | 0.684222 | 3 | 0 | 3 |
| SEC61B | HLA-DPA1 | 0.678991 | 3 | 0 | 3 |
| SEC61B | MTHFD1L | 0.677238 | 3 | 0 | 3 |
| SEC61B | SNX17 | 0.676606 | 3 | 0 | 3 |
| SEC61B | ZNF709 | 0.674334 | 3 | 0 | 3 |
| SEC61B | CMTM6 | 0.673399 | 5 | 0 | 4 |
For details and further investigation, click here
