| Full name: eukaryotic translation initiation factor 4E | Alias Symbol: EIF4E1 | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 1977 | HGNC ID: HGNC:3287 | Ensembl Gene: ENSG00000151247 | OMIM ID: 133440 |
| Drug and gene relationship at DGIdb | |||
EIF4E involved pathways:
Expression of EIF4E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF4E | 1977 | 201437_s_at | -0.0733 | 0.8942 | |
| GSE20347 | EIF4E | 1977 | 201437_s_at | -0.4969 | 0.0008 | |
| GSE23400 | EIF4E | 1977 | 201435_s_at | -0.3360 | 0.0002 | |
| GSE26886 | EIF4E | 1977 | 201437_s_at | -1.2404 | 0.0000 | |
| GSE29001 | EIF4E | 1977 | 201435_s_at | -0.5890 | 0.1048 | |
| GSE38129 | EIF4E | 1977 | 201437_s_at | -0.3254 | 0.0585 | |
| GSE45670 | EIF4E | 1977 | 201435_s_at | -0.1563 | 0.2531 | |
| GSE53622 | EIF4E | 1977 | 530 | -0.4828 | 0.0000 | |
| GSE53624 | EIF4E | 1977 | 530 | -0.5475 | 0.0000 | |
| GSE63941 | EIF4E | 1977 | 201435_s_at | 0.5257 | 0.0692 | |
| GSE77861 | EIF4E | 1977 | 201435_s_at | -0.6632 | 0.1178 | |
| GSE97050 | EIF4E | 1977 | A_23_P118643 | -0.1420 | 0.7085 | |
| SRP007169 | EIF4E | 1977 | RNAseq | -1.0936 | 0.0096 | |
| SRP008496 | EIF4E | 1977 | RNAseq | -1.1286 | 0.0000 | |
| SRP064894 | EIF4E | 1977 | RNAseq | -0.5852 | 0.0010 | |
| SRP133303 | EIF4E | 1977 | RNAseq | -0.0450 | 0.7423 | |
| SRP159526 | EIF4E | 1977 | RNAseq | -0.5758 | 0.0170 | |
| SRP193095 | EIF4E | 1977 | RNAseq | -0.5319 | 0.0000 | |
| SRP219564 | EIF4E | 1977 | RNAseq | -0.7506 | 0.0120 | |
| TCGA | EIF4E | 1977 | RNAseq | 0.0235 | 0.6858 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by EIF4E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF4E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF4E | 1977 | 0 | 12 | 18 | |
| GSE20123 | EIF4E | 1977 | 0 | 12 | 18 | |
| GSE43470 | EIF4E | 1977 | 0 | 15 | 28 | |
| GSE46452 | EIF4E | 1977 | 1 | 36 | 22 | |
| GSE47630 | EIF4E | 1977 | 0 | 20 | 20 | |
| GSE54993 | EIF4E | 1977 | 9 | 0 | 61 | |
| GSE54994 | EIF4E | 1977 | 1 | 11 | 41 | |
| GSE60625 | EIF4E | 1977 | 0 | 3 | 8 | |
| GSE74703 | EIF4E | 1977 | 0 | 13 | 23 | |
| GSE74704 | EIF4E | 1977 | 0 | 6 | 14 | |
| TCGA | EIF4E | 1977 | 8 | 41 | 47 |
Total number of gains: 19; Total number of losses: 169; Total Number of normals: 300.
Somatic mutations of EIF4E:
Generating mutation plots.
Highly correlated genes for EIF4E:
Showing top 20/1358 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF4E | THAP2 | 0.781847 | 4 | 0 | 4 |
| EIF4E | MRPL30 | 0.779768 | 3 | 0 | 3 |
| EIF4E | IMPACT | 0.775643 | 3 | 0 | 3 |
| EIF4E | PPP1R8 | 0.744352 | 4 | 0 | 4 |
| EIF4E | LAMTOR3 | 0.74216 | 11 | 0 | 11 |
| EIF4E | C3orf38 | 0.732768 | 7 | 0 | 7 |
| EIF4E | BCS1L | 0.729439 | 3 | 0 | 3 |
| EIF4E | ZNF70 | 0.725372 | 3 | 0 | 3 |
| EIF4E | PSEN1 | 0.723658 | 3 | 0 | 3 |
| EIF4E | UQCR10 | 0.723515 | 3 | 0 | 3 |
| EIF4E | SLC31A1 | 0.721568 | 4 | 0 | 3 |
| EIF4E | GSKIP | 0.720735 | 6 | 0 | 5 |
| EIF4E | MITD1 | 0.71528 | 4 | 0 | 3 |
| EIF4E | SEC61B | 0.710082 | 3 | 0 | 3 |
| EIF4E | MORN2 | 0.701161 | 3 | 0 | 3 |
| EIF4E | SLC25A26 | 0.699909 | 3 | 0 | 3 |
| EIF4E | IRAK2 | 0.6987 | 6 | 0 | 6 |
| EIF4E | TP53RK | 0.697493 | 3 | 0 | 3 |
| EIF4E | SCP2 | 0.696501 | 11 | 0 | 11 |
| EIF4E | RHBDL2 | 0.696425 | 6 | 0 | 6 |
For details and further investigation, click here
