| Full name: glutathione peroxidase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 2876 | HGNC ID: HGNC:4553 | Ensembl Gene: ENSG00000233276 | OMIM ID: 138320 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
GPX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
Expression of GPX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPX1 | 2876 | 200736_s_at | 0.2072 | 0.5387 | |
| GSE20347 | GPX1 | 2876 | 200736_s_at | -0.2899 | 0.0527 | |
| GSE23400 | GPX1 | 2876 | 200736_s_at | 0.0162 | 0.8527 | |
| GSE26886 | GPX1 | 2876 | 200736_s_at | -0.6537 | 0.0681 | |
| GSE29001 | GPX1 | 2876 | 200736_s_at | -0.4854 | 0.2843 | |
| GSE38129 | GPX1 | 2876 | 200736_s_at | -0.1357 | 0.2980 | |
| GSE45670 | GPX1 | 2876 | 200736_s_at | 0.0761 | 0.7053 | |
| GSE53622 | GPX1 | 2876 | 9531 | 0.0016 | 0.9855 | |
| GSE53624 | GPX1 | 2876 | 9531 | -0.0405 | 0.5976 | |
| GSE63941 | GPX1 | 2876 | 200736_s_at | -1.0620 | 0.0259 | |
| GSE77861 | GPX1 | 2876 | 200736_s_at | -0.1305 | 0.6295 | |
| GSE97050 | GPX1 | 2876 | A_33_P3354322 | 0.1362 | 0.6013 | |
| SRP007169 | GPX1 | 2876 | RNAseq | -0.9438 | 0.0160 | |
| SRP008496 | GPX1 | 2876 | RNAseq | -0.9186 | 0.0010 | |
| SRP064894 | GPX1 | 2876 | RNAseq | 0.5832 | 0.1300 | |
| SRP133303 | GPX1 | 2876 | RNAseq | 0.1660 | 0.3348 | |
| SRP159526 | GPX1 | 2876 | RNAseq | -0.3730 | 0.0795 | |
| SRP193095 | GPX1 | 2876 | RNAseq | -0.2652 | 0.1464 | |
| SRP219564 | GPX1 | 2876 | RNAseq | 0.0522 | 0.8781 | |
| TCGA | GPX1 | 2876 | RNAseq | 0.1156 | 0.0357 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GPX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPX1 | 2876 | 0 | 18 | 12 | |
| GSE20123 | GPX1 | 2876 | 0 | 19 | 11 | |
| GSE43470 | GPX1 | 2876 | 0 | 18 | 25 | |
| GSE46452 | GPX1 | 2876 | 2 | 16 | 41 | |
| GSE47630 | GPX1 | 2876 | 1 | 24 | 15 | |
| GSE54993 | GPX1 | 2876 | 6 | 2 | 62 | |
| GSE54994 | GPX1 | 2876 | 0 | 36 | 17 | |
| GSE60625 | GPX1 | 2876 | 5 | 0 | 6 | |
| GSE74703 | GPX1 | 2876 | 0 | 14 | 22 | |
| GSE74704 | GPX1 | 2876 | 0 | 12 | 8 | |
| TCGA | GPX1 | 2876 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of GPX1:
Generating mutation plots.
Highly correlated genes for GPX1:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPX1 | TPD52L2 | 0.739175 | 3 | 0 | 3 |
| GPX1 | NIT2 | 0.737087 | 3 | 0 | 3 |
| GPX1 | GPR37L1 | 0.734421 | 3 | 0 | 3 |
| GPX1 | ARFGAP2 | 0.731622 | 3 | 0 | 3 |
| GPX1 | MRM1 | 0.727304 | 3 | 0 | 3 |
| GPX1 | SEC61B | 0.726035 | 3 | 0 | 3 |
| GPX1 | NECAP1 | 0.721654 | 3 | 0 | 3 |
| GPX1 | TMEM129 | 0.721117 | 3 | 0 | 3 |
| GPX1 | LEPROT | 0.719619 | 4 | 0 | 4 |
| GPX1 | TCTN1 | 0.710459 | 3 | 0 | 3 |
| GPX1 | ERLEC1 | 0.710304 | 3 | 0 | 3 |
| GPX1 | MPI | 0.708869 | 4 | 0 | 3 |
| GPX1 | SLFN12 | 0.7066 | 3 | 0 | 3 |
| GPX1 | MTFMT | 0.700543 | 3 | 0 | 3 |
| GPX1 | SYS1 | 0.699702 | 3 | 0 | 3 |
| GPX1 | MBTPS1 | 0.690836 | 4 | 0 | 4 |
| GPX1 | NDUFS3 | 0.69013 | 4 | 0 | 3 |
| GPX1 | ASS1 | 0.687025 | 3 | 0 | 3 |
| GPX1 | SMAP2 | 0.685981 | 3 | 0 | 3 |
| GPX1 | ANO10 | 0.681064 | 3 | 0 | 3 |
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