| Full name: semaphorin 3E | Alias Symbol: M-SemaK|KIAA0331|coll-5 | ||
| Type: protein-coding gene | Cytoband: 7q21.11 | ||
| Entrez ID: 9723 | HGNC ID: HGNC:10727 | Ensembl Gene: ENSG00000170381 | OMIM ID: 608166 |
| Drug and gene relationship at DGIdb | |||
SEMA3E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA3E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA3E | 9723 | 206941_x_at | -0.8336 | 0.4076 | |
| GSE20347 | SEMA3E | 9723 | 206941_x_at | 0.0348 | 0.6795 | |
| GSE23400 | SEMA3E | 9723 | 206941_x_at | -0.1039 | 0.0261 | |
| GSE26886 | SEMA3E | 9723 | 206941_x_at | 0.0308 | 0.8126 | |
| GSE29001 | SEMA3E | 9723 | 206941_x_at | 0.0176 | 0.8886 | |
| GSE38129 | SEMA3E | 9723 | 206941_x_at | -0.7488 | 0.0202 | |
| GSE45670 | SEMA3E | 9723 | 206941_x_at | -1.2510 | 0.0000 | |
| GSE53622 | SEMA3E | 9723 | 57914 | -2.1957 | 0.0000 | |
| GSE53624 | SEMA3E | 9723 | 57914 | -2.0206 | 0.0000 | |
| GSE63941 | SEMA3E | 9723 | 206941_x_at | -1.1776 | 0.0229 | |
| GSE77861 | SEMA3E | 9723 | 206941_x_at | 0.0232 | 0.7670 | |
| SRP064894 | SEMA3E | 9723 | RNAseq | -0.3065 | 0.5113 | |
| SRP133303 | SEMA3E | 9723 | RNAseq | -1.2721 | 0.0002 | |
| SRP159526 | SEMA3E | 9723 | RNAseq | -0.4266 | 0.5378 | |
| SRP193095 | SEMA3E | 9723 | RNAseq | 0.0385 | 0.9005 | |
| SRP219564 | SEMA3E | 9723 | RNAseq | -1.5778 | 0.1633 | |
| TCGA | SEMA3E | 9723 | RNAseq | -1.6734 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SEMA3E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA3E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA3E | 9723 | 12 | 1 | 17 | |
| GSE20123 | SEMA3E | 9723 | 11 | 1 | 18 | |
| GSE43470 | SEMA3E | 9723 | 4 | 1 | 38 | |
| GSE46452 | SEMA3E | 9723 | 11 | 0 | 48 | |
| GSE47630 | SEMA3E | 9723 | 7 | 3 | 30 | |
| GSE54993 | SEMA3E | 9723 | 1 | 7 | 62 | |
| GSE54994 | SEMA3E | 9723 | 16 | 3 | 34 | |
| GSE60625 | SEMA3E | 9723 | 0 | 0 | 11 | |
| GSE74703 | SEMA3E | 9723 | 3 | 1 | 32 | |
| GSE74704 | SEMA3E | 9723 | 7 | 1 | 12 | |
| TCGA | SEMA3E | 9723 | 48 | 6 | 42 |
Total number of gains: 120; Total number of losses: 24; Total Number of normals: 344.
Somatic mutations of SEMA3E:
Generating mutation plots.
Highly correlated genes for SEMA3E:
Showing top 20/745 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA3E | RBPMS2 | 0.783081 | 4 | 0 | 4 |
| SEMA3E | XKR4 | 0.780124 | 4 | 0 | 4 |
| SEMA3E | HOXA4 | 0.778737 | 4 | 0 | 4 |
| SEMA3E | PGR | 0.775679 | 5 | 0 | 5 |
| SEMA3E | OSR1 | 0.775591 | 3 | 0 | 3 |
| SEMA3E | CADM2 | 0.768687 | 3 | 0 | 3 |
| SEMA3E | C1QTNF2 | 0.768249 | 4 | 0 | 4 |
| SEMA3E | ENPP6 | 0.766348 | 4 | 0 | 4 |
| SEMA3E | RNASE4 | 0.752198 | 4 | 0 | 4 |
| SEMA3E | PI16 | 0.751559 | 4 | 0 | 4 |
| SEMA3E | MAMDC2 | 0.750479 | 4 | 0 | 4 |
| SEMA3E | UBXN10 | 0.750235 | 3 | 0 | 3 |
| SEMA3E | C1QTNF7 | 0.745613 | 5 | 0 | 4 |
| SEMA3E | ABCA6 | 0.745174 | 7 | 0 | 7 |
| SEMA3E | INPP5A | 0.7445 | 6 | 0 | 6 |
| SEMA3E | MYOM1 | 0.743658 | 8 | 0 | 7 |
| SEMA3E | SHISA3 | 0.739557 | 6 | 0 | 4 |
| SEMA3E | CACNA1H | 0.734322 | 4 | 0 | 3 |
| SEMA3E | PEG3 | 0.731374 | 5 | 0 | 4 |
| SEMA3E | CASQ2 | 0.731256 | 8 | 0 | 7 |
For details and further investigation, click here
