| Full name: inositol polyphosphate-5-phosphatase A | Alias Symbol: 5PTASE | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 3632 | HGNC ID: HGNC:6076 | Ensembl Gene: ENSG00000068383 | OMIM ID: 600106 |
| Drug and gene relationship at DGIdb | |||
Expression of INPP5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INPP5A | 3632 | 203006_at | -0.7502 | 0.4009 | |
| GSE20347 | INPP5A | 3632 | 203006_at | -0.4161 | 0.0341 | |
| GSE23400 | INPP5A | 3632 | 203006_at | -0.6967 | 0.0000 | |
| GSE26886 | INPP5A | 3632 | 203006_at | -0.8955 | 0.0000 | |
| GSE29001 | INPP5A | 3632 | 203006_at | -0.5056 | 0.1059 | |
| GSE38129 | INPP5A | 3632 | 203006_at | -0.8604 | 0.0012 | |
| GSE45670 | INPP5A | 3632 | 203006_at | -0.7852 | 0.0000 | |
| GSE53622 | INPP5A | 3632 | 168453 | -0.9280 | 0.0000 | |
| GSE53624 | INPP5A | 3632 | 168453 | -0.7946 | 0.0000 | |
| GSE63941 | INPP5A | 3632 | 203006_at | -0.5162 | 0.3595 | |
| GSE77861 | INPP5A | 3632 | 203006_at | -0.2074 | 0.3742 | |
| GSE97050 | INPP5A | 3632 | A_33_P3374190 | -0.8391 | 0.1791 | |
| SRP007169 | INPP5A | 3632 | RNAseq | -1.2810 | 0.0058 | |
| SRP008496 | INPP5A | 3632 | RNAseq | -0.7956 | 0.0072 | |
| SRP064894 | INPP5A | 3632 | RNAseq | -0.9387 | 0.0000 | |
| SRP133303 | INPP5A | 3632 | RNAseq | -0.4048 | 0.0826 | |
| SRP159526 | INPP5A | 3632 | RNAseq | -0.4010 | 0.2971 | |
| SRP193095 | INPP5A | 3632 | RNAseq | -0.3886 | 0.0026 | |
| SRP219564 | INPP5A | 3632 | RNAseq | -0.7650 | 0.2900 | |
| TCGA | INPP5A | 3632 | RNAseq | -0.4289 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by INPP5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INPP5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INPP5A | 3632 | 2 | 8 | 20 | |
| GSE20123 | INPP5A | 3632 | 2 | 9 | 19 | |
| GSE43470 | INPP5A | 3632 | 0 | 9 | 34 | |
| GSE46452 | INPP5A | 3632 | 1 | 11 | 47 | |
| GSE47630 | INPP5A | 3632 | 4 | 13 | 23 | |
| GSE54993 | INPP5A | 3632 | 8 | 2 | 60 | |
| GSE54994 | INPP5A | 3632 | 1 | 9 | 43 | |
| GSE60625 | INPP5A | 3632 | 0 | 0 | 11 | |
| GSE74703 | INPP5A | 3632 | 0 | 6 | 30 | |
| GSE74704 | INPP5A | 3632 | 2 | 4 | 14 | |
| TCGA | INPP5A | 3632 | 7 | 28 | 61 |
Total number of gains: 27; Total number of losses: 99; Total Number of normals: 362.
Somatic mutations of INPP5A:
Generating mutation plots.
Highly correlated genes for INPP5A:
Showing top 20/1066 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INPP5A | ANO5 | 0.776803 | 5 | 0 | 5 |
| INPP5A | CBX7 | 0.776214 | 8 | 0 | 8 |
| INPP5A | EPM2A | 0.764441 | 6 | 0 | 5 |
| INPP5A | ADAMTSL3 | 0.763948 | 5 | 0 | 4 |
| INPP5A | MAMDC2 | 0.751797 | 6 | 0 | 6 |
| INPP5A | SLC35F1 | 0.749718 | 3 | 0 | 3 |
| INPP5A | FRRS1L | 0.747342 | 5 | 0 | 5 |
| INPP5A | SEMA3E | 0.7445 | 6 | 0 | 6 |
| INPP5A | CTNNA3 | 0.743996 | 5 | 0 | 5 |
| INPP5A | CSRP1 | 0.740721 | 8 | 0 | 8 |
| INPP5A | RNASE4 | 0.740326 | 6 | 0 | 5 |
| INPP5A | SCN7A | 0.738619 | 7 | 0 | 7 |
| INPP5A | IQUB | 0.735877 | 3 | 0 | 3 |
| INPP5A | CYP2U1 | 0.733895 | 4 | 0 | 3 |
| INPP5A | C1QTNF7 | 0.733744 | 6 | 0 | 6 |
| INPP5A | N6AMT1 | 0.73067 | 3 | 0 | 3 |
| INPP5A | CACNA1C | 0.729938 | 5 | 0 | 4 |
| INPP5A | PPP3CB | 0.723267 | 8 | 0 | 8 |
| INPP5A | CYP21A2 | 0.720678 | 3 | 0 | 3 |
| INPP5A | FNBP1 | 0.719256 | 10 | 0 | 10 |
For details and further investigation, click here
