| Full name: SUMO specific peptidase 2 | Alias Symbol: SMT3IP2|KIAA1331|DKFZp762A2316|AXAM2 | ||
| Type: protein-coding gene | Cytoband: 3q27.2 | ||
| Entrez ID: 59343 | HGNC ID: HGNC:23116 | Ensembl Gene: ENSG00000163904 | OMIM ID: 608261 |
| Drug and gene relationship at DGIdb | |||
SENP2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SENP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SENP2 | 59343 | 222523_at | 0.3154 | 0.3183 | |
| GSE20347 | SENP2 | 59343 | 218122_s_at | 0.5234 | 0.0001 | |
| GSE23400 | SENP2 | 59343 | 218122_s_at | 0.3077 | 0.0000 | |
| GSE26886 | SENP2 | 59343 | 222523_at | -0.1185 | 0.6996 | |
| GSE29001 | SENP2 | 59343 | 218122_s_at | 0.1582 | 0.3659 | |
| GSE38129 | SENP2 | 59343 | 218122_s_at | 0.6317 | 0.0000 | |
| GSE45670 | SENP2 | 59343 | 222523_at | 0.4555 | 0.0535 | |
| GSE53622 | SENP2 | 59343 | 15402 | 0.6505 | 0.0000 | |
| GSE53624 | SENP2 | 59343 | 15402 | 0.6439 | 0.0000 | |
| GSE63941 | SENP2 | 59343 | 218122_s_at | 1.3783 | 0.0083 | |
| GSE77861 | SENP2 | 59343 | 218122_s_at | 0.3727 | 0.2088 | |
| GSE97050 | SENP2 | 59343 | A_32_P74712 | 0.2341 | 0.3797 | |
| SRP007169 | SENP2 | 59343 | RNAseq | 1.7727 | 0.0008 | |
| SRP008496 | SENP2 | 59343 | RNAseq | 1.9556 | 0.0000 | |
| SRP064894 | SENP2 | 59343 | RNAseq | 0.3402 | 0.0816 | |
| SRP133303 | SENP2 | 59343 | RNAseq | 0.8244 | 0.0000 | |
| SRP159526 | SENP2 | 59343 | RNAseq | 1.0988 | 0.0000 | |
| SRP193095 | SENP2 | 59343 | RNAseq | 0.4934 | 0.0000 | |
| SRP219564 | SENP2 | 59343 | RNAseq | 0.0311 | 0.9081 | |
| TCGA | SENP2 | 59343 | RNAseq | 0.1083 | 0.0520 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SENP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SENP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SENP2 | 59343 | 25 | 0 | 5 | |
| GSE20123 | SENP2 | 59343 | 25 | 0 | 5 | |
| GSE43470 | SENP2 | 59343 | 23 | 0 | 20 | |
| GSE46452 | SENP2 | 59343 | 19 | 1 | 39 | |
| GSE47630 | SENP2 | 59343 | 27 | 2 | 11 | |
| GSE54993 | SENP2 | 59343 | 1 | 19 | 50 | |
| GSE54994 | SENP2 | 59343 | 40 | 0 | 13 | |
| GSE60625 | SENP2 | 59343 | 0 | 6 | 5 | |
| GSE74703 | SENP2 | 59343 | 20 | 0 | 16 | |
| GSE74704 | SENP2 | 59343 | 17 | 0 | 3 | |
| TCGA | SENP2 | 59343 | 77 | 0 | 19 |
Total number of gains: 274; Total number of losses: 28; Total Number of normals: 186.
Somatic mutations of SENP2:
Generating mutation plots.
Highly correlated genes for SENP2:
Showing top 20/1052 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SENP2 | FAM86C1 | 0.777533 | 3 | 0 | 3 |
| SENP2 | INO80E | 0.759735 | 3 | 0 | 3 |
| SENP2 | FGFR1OP2 | 0.757624 | 3 | 0 | 3 |
| SENP2 | RNF40 | 0.743677 | 3 | 0 | 3 |
| SENP2 | LRRC58 | 0.742048 | 4 | 0 | 3 |
| SENP2 | FAM168A | 0.736691 | 3 | 0 | 3 |
| SENP2 | TTC30B | 0.714525 | 3 | 0 | 3 |
| SENP2 | PARL | 0.71304 | 12 | 0 | 11 |
| SENP2 | AP2M1 | 0.711771 | 10 | 0 | 8 |
| SENP2 | CCDC117 | 0.711603 | 4 | 0 | 4 |
| SENP2 | ORAI1 | 0.711056 | 4 | 0 | 3 |
| SENP2 | C15orf61 | 0.708558 | 3 | 0 | 3 |
| SENP2 | MRPL47 | 0.706927 | 8 | 0 | 7 |
| SENP2 | MAGEF1 | 0.705534 | 13 | 0 | 11 |
| SENP2 | PSMD2 | 0.702463 | 11 | 0 | 10 |
| SENP2 | SPSB2 | 0.702261 | 3 | 0 | 3 |
| SENP2 | SLC25A10 | 0.695309 | 3 | 0 | 3 |
| SENP2 | MICU1 | 0.695145 | 3 | 0 | 3 |
| SENP2 | CTDSPL2 | 0.692307 | 6 | 0 | 6 |
| SENP2 | ALG3 | 0.691459 | 10 | 0 | 8 |
For details and further investigation, click here
