| Full name: presenilin associated rhomboid like | Alias Symbol: PRO2207|PSARL1|RHBDS1 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 55486 | HGNC ID: HGNC:18253 | Ensembl Gene: ENSG00000175193 | OMIM ID: 607858 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PARL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PARL | 55486 | 218271_s_at | 0.5084 | 0.1346 | |
| GSE20347 | PARL | 55486 | 218271_s_at | 0.9915 | 0.0000 | |
| GSE23400 | PARL | 55486 | 218271_s_at | 0.7581 | 0.0000 | |
| GSE26886 | PARL | 55486 | 218271_s_at | 0.7044 | 0.0001 | |
| GSE29001 | PARL | 55486 | 218271_s_at | 0.8383 | 0.0044 | |
| GSE38129 | PARL | 55486 | 218271_s_at | 0.8491 | 0.0000 | |
| GSE45670 | PARL | 55486 | 218271_s_at | 0.3069 | 0.1162 | |
| GSE53622 | PARL | 55486 | 99715 | 0.5786 | 0.0000 | |
| GSE53624 | PARL | 55486 | 99715 | 0.8734 | 0.0000 | |
| GSE63941 | PARL | 55486 | 218271_s_at | 0.7116 | 0.2476 | |
| GSE77861 | PARL | 55486 | 218271_s_at | 0.8600 | 0.0314 | |
| GSE97050 | PARL | 55486 | A_33_P3335451 | 0.3058 | 0.2388 | |
| SRP007169 | PARL | 55486 | RNAseq | 1.7840 | 0.0002 | |
| SRP008496 | PARL | 55486 | RNAseq | 1.4364 | 0.0000 | |
| SRP064894 | PARL | 55486 | RNAseq | 0.6073 | 0.0022 | |
| SRP133303 | PARL | 55486 | RNAseq | 0.9096 | 0.0000 | |
| SRP159526 | PARL | 55486 | RNAseq | 1.5027 | 0.0000 | |
| SRP193095 | PARL | 55486 | RNAseq | 0.6796 | 0.0000 | |
| SRP219564 | PARL | 55486 | RNAseq | 0.5017 | 0.2081 | |
| TCGA | PARL | 55486 | RNAseq | 0.1528 | 0.0064 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PARL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PARL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PARL | 55486 | 25 | 0 | 5 | |
| GSE20123 | PARL | 55486 | 25 | 0 | 5 | |
| GSE43470 | PARL | 55486 | 24 | 0 | 19 | |
| GSE46452 | PARL | 55486 | 19 | 1 | 39 | |
| GSE47630 | PARL | 55486 | 27 | 2 | 11 | |
| GSE54993 | PARL | 55486 | 1 | 19 | 50 | |
| GSE54994 | PARL | 55486 | 41 | 0 | 12 | |
| GSE60625 | PARL | 55486 | 0 | 6 | 5 | |
| GSE74703 | PARL | 55486 | 20 | 0 | 16 | |
| GSE74704 | PARL | 55486 | 17 | 0 | 3 | |
| TCGA | PARL | 55486 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of PARL:
Generating mutation plots.
Highly correlated genes for PARL:
Showing top 20/1833 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PARL | PCGF6 | 0.837924 | 3 | 0 | 3 |
| PARL | MRPL47 | 0.763391 | 9 | 0 | 9 |
| PARL | POLR2H | 0.762925 | 13 | 0 | 12 |
| PARL | PSMD2 | 0.755575 | 13 | 0 | 13 |
| PARL | U2SURP | 0.748967 | 9 | 0 | 9 |
| PARL | ACTL6A | 0.748535 | 13 | 0 | 13 |
| PARL | RPRD1B | 0.732486 | 3 | 0 | 3 |
| PARL | EIF2B5 | 0.732144 | 12 | 0 | 11 |
| PARL | GMPS | 0.730556 | 12 | 0 | 11 |
| PARL | AP2M1 | 0.728854 | 12 | 0 | 11 |
| PARL | LRRC58 | 0.7272 | 5 | 0 | 5 |
| PARL | PSMB4 | 0.725592 | 11 | 0 | 10 |
| PARL | BAD | 0.725471 | 3 | 0 | 3 |
| PARL | RNF7 | 0.725334 | 13 | 0 | 12 |
| PARL | SENP1 | 0.722778 | 3 | 0 | 3 |
| PARL | USP14 | 0.720211 | 7 | 0 | 7 |
| PARL | PIGX | 0.716851 | 8 | 0 | 8 |
| PARL | HLTF | 0.715863 | 11 | 0 | 11 |
| PARL | SENP2 | 0.71304 | 12 | 0 | 11 |
| PARL | FXR1 | 0.713035 | 11 | 0 | 9 |
For details and further investigation, click here
