| Full name: SUMO specific peptidase 3 | Alias Symbol: DKFZP586K0919|SSP3|DKFZp762A152|SMT3IP1|Ulp1 | ||
| Type: protein-coding gene | Cytoband: 17p13 | ||
| Entrez ID: 26168 | HGNC ID: HGNC:17862 | Ensembl Gene: ENSG00000161956 | OMIM ID: 612844 |
| Drug and gene relationship at DGIdb | |||
Expression of SENP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SENP3 | 26168 | 203871_at | 0.5140 | 0.0643 | |
| GSE20347 | SENP3 | 26168 | 203871_at | 0.3629 | 0.0451 | |
| GSE23400 | SENP3 | 26168 | 203871_at | 0.3561 | 0.0000 | |
| GSE26886 | SENP3 | 26168 | 203871_at | 0.0580 | 0.7745 | |
| GSE29001 | SENP3 | 26168 | 203871_at | 0.4087 | 0.0072 | |
| GSE38129 | SENP3 | 26168 | 203871_at | 0.5246 | 0.0002 | |
| GSE45670 | SENP3 | 26168 | 203871_at | 0.4633 | 0.0004 | |
| GSE53622 | SENP3 | 26168 | 109675 | 0.6526 | 0.0000 | |
| GSE53624 | SENP3 | 26168 | 109675 | 0.7610 | 0.0000 | |
| GSE63941 | SENP3 | 26168 | 203871_at | 1.0185 | 0.0020 | |
| GSE77861 | SENP3 | 26168 | 203871_at | 0.4424 | 0.0031 | |
| GSE97050 | SENP3 | 26168 | A_23_P164000 | 0.5018 | 0.1602 | |
| SRP007169 | SENP3 | 26168 | RNAseq | 0.2655 | 0.4242 | |
| SRP008496 | SENP3 | 26168 | RNAseq | 0.5802 | 0.0028 | |
| SRP064894 | SENP3 | 26168 | RNAseq | 0.5263 | 0.0010 | |
| SRP133303 | SENP3 | 26168 | RNAseq | 0.5627 | 0.0008 | |
| SRP159526 | SENP3 | 26168 | RNAseq | 0.7308 | 0.0000 | |
| SRP193095 | SENP3 | 26168 | RNAseq | 0.6951 | 0.0000 | |
| SRP219564 | SENP3 | 26168 | RNAseq | 0.4095 | 0.2590 | |
| TCGA | SENP3 | 26168 | RNAseq | 0.1539 | 0.0032 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SENP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SENP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SENP3 | 26168 | 4 | 2 | 24 | |
| GSE20123 | SENP3 | 26168 | 4 | 3 | 23 | |
| GSE43470 | SENP3 | 26168 | 1 | 4 | 38 | |
| GSE46452 | SENP3 | 26168 | 34 | 1 | 24 | |
| GSE47630 | SENP3 | 26168 | 7 | 1 | 32 | |
| GSE54993 | SENP3 | 26168 | 4 | 3 | 63 | |
| GSE54994 | SENP3 | 26168 | 5 | 8 | 40 | |
| GSE60625 | SENP3 | 26168 | 4 | 0 | 7 | |
| GSE74703 | SENP3 | 26168 | 1 | 2 | 33 | |
| GSE74704 | SENP3 | 26168 | 2 | 1 | 17 | |
| TCGA | SENP3 | 26168 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of SENP3:
Generating mutation plots.
Highly correlated genes for SENP3:
Showing top 20/1793 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SENP3 | CUL7 | 0.818478 | 3 | 0 | 3 |
| SENP3 | SLC39A3 | 0.817598 | 3 | 0 | 3 |
| SENP3 | RILPL2 | 0.794243 | 3 | 0 | 3 |
| SENP3 | SCNM1 | 0.779668 | 3 | 0 | 3 |
| SENP3 | TMTC4 | 0.779432 | 3 | 0 | 3 |
| SENP3 | DGCR8 | 0.778322 | 3 | 0 | 3 |
| SENP3 | SEC23IP | 0.76742 | 3 | 0 | 3 |
| SENP3 | SAFB2 | 0.766901 | 3 | 0 | 3 |
| SENP3 | EFTUD2 | 0.758568 | 7 | 0 | 6 |
| SENP3 | PIK3R3 | 0.754481 | 3 | 0 | 3 |
| SENP3 | NF1 | 0.742523 | 3 | 0 | 3 |
| SENP3 | APLNR | 0.741459 | 3 | 0 | 3 |
| SENP3 | UNC119 | 0.736015 | 6 | 0 | 6 |
| SENP3 | LRIF1 | 0.733195 | 3 | 0 | 3 |
| SENP3 | CRTC2 | 0.731131 | 5 | 0 | 4 |
| SENP3 | PYCR2 | 0.727162 | 3 | 0 | 3 |
| SENP3 | WDR81 | 0.726458 | 4 | 0 | 3 |
| SENP3 | TP53I13 | 0.72462 | 6 | 0 | 5 |
| SENP3 | METTL2A | 0.724473 | 3 | 0 | 3 |
| SENP3 | RAB34 | 0.721141 | 3 | 0 | 3 |
For details and further investigation, click here
