| Full name: protein phosphatase 2 regulatory subunit Bgamma | Alias Symbol: PR52|IMYPNO|MGC33570|PR55G|B55gamma | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 5522 | HGNC ID: HGNC:9306 | Ensembl Gene: ENSG00000074211 | OMIM ID: 605997 |
| Drug and gene relationship at DGIdb | |||
PPP2R2C involved pathways:
Expression of PPP2R2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP2R2C | 5522 | 228010_at | -0.5630 | 0.7918 | |
| GSE26886 | PPP2R2C | 5522 | 228010_at | -1.5374 | 0.0008 | |
| GSE45670 | PPP2R2C | 5522 | 228010_at | 0.2423 | 0.4568 | |
| GSE53622 | PPP2R2C | 5522 | 148481 | -0.7330 | 0.0329 | |
| GSE53624 | PPP2R2C | 5522 | 148481 | -1.1668 | 0.0000 | |
| GSE63941 | PPP2R2C | 5522 | 228010_at | 3.3302 | 0.0110 | |
| GSE77861 | PPP2R2C | 5522 | 228010_at | -0.1722 | 0.7480 | |
| GSE97050 | PPP2R2C | 5522 | A_24_P3415 | 0.1237 | 0.6053 | |
| SRP007169 | PPP2R2C | 5522 | RNAseq | -1.8971 | 0.0004 | |
| SRP008496 | PPP2R2C | 5522 | RNAseq | -1.6927 | 0.0000 | |
| SRP064894 | PPP2R2C | 5522 | RNAseq | -1.1236 | 0.0204 | |
| SRP133303 | PPP2R2C | 5522 | RNAseq | -1.2166 | 0.0000 | |
| SRP159526 | PPP2R2C | 5522 | RNAseq | -0.9130 | 0.1067 | |
| SRP219564 | PPP2R2C | 5522 | RNAseq | -1.0006 | 0.3431 | |
| TCGA | PPP2R2C | 5522 | RNAseq | 0.9091 | 0.0007 |
Upregulated datasets: 1; Downregulated datasets: 6.
Survival by PPP2R2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP2R2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP2R2C | 5522 | 0 | 18 | 12 | |
| GSE20123 | PPP2R2C | 5522 | 0 | 18 | 12 | |
| GSE43470 | PPP2R2C | 5522 | 0 | 17 | 26 | |
| GSE46452 | PPP2R2C | 5522 | 1 | 36 | 22 | |
| GSE47630 | PPP2R2C | 5522 | 1 | 19 | 20 | |
| GSE54993 | PPP2R2C | 5522 | 10 | 0 | 60 | |
| GSE54994 | PPP2R2C | 5522 | 3 | 12 | 38 | |
| GSE60625 | PPP2R2C | 5522 | 0 | 0 | 11 | |
| GSE74703 | PPP2R2C | 5522 | 0 | 13 | 23 | |
| GSE74704 | PPP2R2C | 5522 | 0 | 10 | 10 | |
| TCGA | PPP2R2C | 5522 | 8 | 48 | 40 |
Total number of gains: 23; Total number of losses: 191; Total Number of normals: 274.
Somatic mutations of PPP2R2C:
Generating mutation plots.
Highly correlated genes for PPP2R2C:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP2R2C | PSPH | 0.690315 | 3 | 0 | 3 |
| PPP2R2C | SEPSECS | 0.687631 | 3 | 0 | 3 |
| PPP2R2C | SCN8A | 0.682619 | 3 | 0 | 3 |
| PPP2R2C | PGLYRP3 | 0.68094 | 3 | 0 | 3 |
| PPP2R2C | ANKZF1 | 0.675954 | 3 | 0 | 3 |
| PPP2R2C | LMNTD2 | 0.674116 | 3 | 0 | 3 |
| PPP2R2C | PGM2 | 0.669929 | 7 | 0 | 6 |
| PPP2R2C | S100A12 | 0.664353 | 6 | 0 | 5 |
| PPP2R2C | S100A9 | 0.664267 | 5 | 0 | 4 |
| PPP2R2C | PRRG4 | 0.66205 | 7 | 0 | 7 |
| PPP2R2C | PRR14L | 0.659689 | 3 | 0 | 3 |
| PPP2R2C | TMEM167A | 0.659438 | 3 | 0 | 3 |
| PPP2R2C | CLCA2 | 0.657842 | 6 | 0 | 5 |
| PPP2R2C | RABGGTA | 0.657811 | 7 | 0 | 6 |
| PPP2R2C | DIAPH1 | 0.651771 | 5 | 0 | 4 |
| PPP2R2C | HSBP1 | 0.651322 | 3 | 0 | 3 |
| PPP2R2C | GTF2IRD1 | 0.649357 | 3 | 0 | 3 |
| PPP2R2C | CWH43 | 0.648829 | 5 | 0 | 5 |
| PPP2R2C | TRIM65 | 0.647926 | 3 | 0 | 3 |
| PPP2R2C | CA12 | 0.647677 | 6 | 0 | 4 |
For details and further investigation, click here
