| Full name: SH3 domain containing ring finger 2 | Alias Symbol: FLJ23654|RNF158|Hepp1|POSHER | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 153769 | HGNC ID: HGNC:26299 | Ensembl Gene: ENSG00000156463 | OMIM ID: 613377 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3RF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3RF2 | 153769 | 243582_at | -1.1681 | 0.1793 | |
| GSE26886 | SH3RF2 | 153769 | 243582_at | -2.1329 | 0.0001 | |
| GSE45670 | SH3RF2 | 153769 | 243582_at | -0.5539 | 0.0253 | |
| GSE53622 | SH3RF2 | 153769 | 30966 | -1.1146 | 0.0000 | |
| GSE53624 | SH3RF2 | 153769 | 30966 | -1.2538 | 0.0000 | |
| GSE63941 | SH3RF2 | 153769 | 228892_at | 2.5473 | 0.0014 | |
| GSE77861 | SH3RF2 | 153769 | 238827_at | -0.2650 | 0.4839 | |
| GSE97050 | SH3RF2 | 153769 | A_24_P120537 | 0.6500 | 0.5183 | |
| SRP007169 | SH3RF2 | 153769 | RNAseq | -1.6050 | 0.0000 | |
| SRP008496 | SH3RF2 | 153769 | RNAseq | -1.8340 | 0.0000 | |
| SRP064894 | SH3RF2 | 153769 | RNAseq | -1.4761 | 0.0001 | |
| SRP133303 | SH3RF2 | 153769 | RNAseq | -1.5048 | 0.0000 | |
| SRP159526 | SH3RF2 | 153769 | RNAseq | -2.0196 | 0.0016 | |
| SRP193095 | SH3RF2 | 153769 | RNAseq | -1.1241 | 0.0000 | |
| SRP219564 | SH3RF2 | 153769 | RNAseq | -2.3246 | 0.0141 | |
| TCGA | SH3RF2 | 153769 | RNAseq | -0.1744 | 0.1897 |
Upregulated datasets: 1; Downregulated datasets: 10.
Survival by SH3RF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3RF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3RF2 | 153769 | 1 | 12 | 17 | |
| GSE20123 | SH3RF2 | 153769 | 1 | 12 | 17 | |
| GSE43470 | SH3RF2 | 153769 | 2 | 9 | 32 | |
| GSE46452 | SH3RF2 | 153769 | 0 | 27 | 32 | |
| GSE47630 | SH3RF2 | 153769 | 1 | 19 | 20 | |
| GSE54993 | SH3RF2 | 153769 | 9 | 1 | 60 | |
| GSE54994 | SH3RF2 | 153769 | 2 | 14 | 37 | |
| GSE60625 | SH3RF2 | 153769 | 0 | 0 | 11 | |
| GSE74703 | SH3RF2 | 153769 | 2 | 7 | 27 | |
| GSE74704 | SH3RF2 | 153769 | 1 | 7 | 12 | |
| TCGA | SH3RF2 | 153769 | 3 | 40 | 53 |
Total number of gains: 22; Total number of losses: 148; Total Number of normals: 318.
Somatic mutations of SH3RF2:
Generating mutation plots.
Highly correlated genes for SH3RF2:
Showing top 20/837 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3RF2 | ARAP2 | 0.799225 | 3 | 0 | 3 |
| SH3RF2 | SLPI | 0.762266 | 7 | 0 | 7 |
| SH3RF2 | KRT6C | 0.754462 | 3 | 0 | 3 |
| SH3RF2 | EHF | 0.752544 | 8 | 0 | 8 |
| SH3RF2 | MAST4 | 0.746204 | 5 | 0 | 5 |
| SH3RF2 | LCN2 | 0.742458 | 6 | 0 | 6 |
| SH3RF2 | CTNND1 | 0.734176 | 3 | 0 | 3 |
| SH3RF2 | CTNNBIP1 | 0.727274 | 4 | 0 | 4 |
| SH3RF2 | CDH1 | 0.718715 | 5 | 0 | 5 |
| SH3RF2 | FZD10 | 0.71731 | 3 | 0 | 3 |
| SH3RF2 | SDR16C5 | 0.71126 | 4 | 0 | 4 |
| SH3RF2 | CKMT1A | 0.710667 | 3 | 0 | 3 |
| SH3RF2 | BTBD11 | 0.710459 | 6 | 0 | 6 |
| SH3RF2 | CWH43 | 0.710208 | 5 | 0 | 4 |
| SH3RF2 | DSG3 | 0.706857 | 8 | 0 | 7 |
| SH3RF2 | TMPRSS11D | 0.706376 | 6 | 0 | 6 |
| SH3RF2 | KRT83 | 0.705607 | 4 | 0 | 3 |
| SH3RF2 | MAL2 | 0.705133 | 7 | 0 | 7 |
| SH3RF2 | FAM83C | 0.704959 | 5 | 0 | 5 |
| SH3RF2 | DSC2 | 0.704756 | 8 | 0 | 8 |
For details and further investigation, click here
