| Full name: secretion regulating guanine nucleotide exchange factor | Alias Symbol: DelGEF|Gnefr | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 26297 | HGNC ID: HGNC:17499 | Ensembl Gene: ENSG00000129158 | OMIM ID: 606051 |
| Drug and gene relationship at DGIdb | |||
Expression of SERGEF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERGEF | 26297 | 232983_s_at | -0.0948 | 0.8847 | |
| GSE20347 | SERGEF | 26297 | 220482_s_at | -0.1065 | 0.1649 | |
| GSE23400 | SERGEF | 26297 | 220482_s_at | -0.0642 | 0.0211 | |
| GSE26886 | SERGEF | 26297 | 232983_s_at | 0.8935 | 0.0001 | |
| GSE29001 | SERGEF | 26297 | 220482_s_at | -0.0031 | 0.9850 | |
| GSE38129 | SERGEF | 26297 | 220482_s_at | -0.1401 | 0.1158 | |
| GSE45670 | SERGEF | 26297 | 232983_s_at | -0.3649 | 0.0206 | |
| GSE53622 | SERGEF | 26297 | 24294 | -0.4178 | 0.0000 | |
| GSE53624 | SERGEF | 26297 | 24294 | -0.1141 | 0.0453 | |
| GSE63941 | SERGEF | 26297 | 232983_s_at | -0.6386 | 0.0301 | |
| GSE77861 | SERGEF | 26297 | 232983_s_at | 0.2195 | 0.2498 | |
| GSE97050 | SERGEF | 26297 | A_24_P364087 | -0.3678 | 0.3716 | |
| SRP007169 | SERGEF | 26297 | RNAseq | 0.2087 | 0.6922 | |
| SRP008496 | SERGEF | 26297 | RNAseq | 0.0946 | 0.8096 | |
| SRP064894 | SERGEF | 26297 | RNAseq | 0.0543 | 0.8754 | |
| SRP133303 | SERGEF | 26297 | RNAseq | -0.0120 | 0.9391 | |
| SRP159526 | SERGEF | 26297 | RNAseq | -0.5016 | 0.0269 | |
| SRP193095 | SERGEF | 26297 | RNAseq | -0.1819 | 0.1045 | |
| SRP219564 | SERGEF | 26297 | RNAseq | -0.2113 | 0.7019 | |
| TCGA | SERGEF | 26297 | RNAseq | -0.2021 | 0.0028 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SERGEF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERGEF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERGEF | 26297 | 0 | 10 | 20 | |
| GSE20123 | SERGEF | 26297 | 0 | 10 | 20 | |
| GSE43470 | SERGEF | 26297 | 1 | 5 | 37 | |
| GSE46452 | SERGEF | 26297 | 7 | 5 | 47 | |
| GSE47630 | SERGEF | 26297 | 3 | 10 | 27 | |
| GSE54993 | SERGEF | 26297 | 3 | 0 | 67 | |
| GSE54994 | SERGEF | 26297 | 3 | 12 | 38 | |
| GSE60625 | SERGEF | 26297 | 0 | 0 | 11 | |
| GSE74703 | SERGEF | 26297 | 1 | 3 | 32 | |
| GSE74704 | SERGEF | 26297 | 0 | 9 | 11 | |
| TCGA | SERGEF | 26297 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 93; Total Number of normals: 366.
Somatic mutations of SERGEF:
Generating mutation plots.
Highly correlated genes for SERGEF:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERGEF | TAS2R14 | 0.681222 | 3 | 0 | 3 |
| SERGEF | ZSCAN21 | 0.6784 | 3 | 0 | 3 |
| SERGEF | PDZD4 | 0.661795 | 4 | 0 | 3 |
| SERGEF | CHIC1 | 0.650253 | 3 | 0 | 3 |
| SERGEF | CCDC59 | 0.643935 | 3 | 0 | 3 |
| SERGEF | PTPDC1 | 0.637818 | 3 | 0 | 3 |
| SERGEF | STAT5B | 0.635033 | 3 | 0 | 3 |
| SERGEF | PPP1R12C | 0.634481 | 4 | 0 | 3 |
| SERGEF | ITSN1 | 0.632603 | 4 | 0 | 3 |
| SERGEF | NUDT11 | 0.627414 | 3 | 0 | 3 |
| SERGEF | RNF115 | 0.620823 | 4 | 0 | 3 |
| SERGEF | HSPB3 | 0.618003 | 4 | 0 | 3 |
| SERGEF | NDUFB10 | 0.617937 | 3 | 0 | 3 |
| SERGEF | ANKS1B | 0.617361 | 3 | 0 | 3 |
| SERGEF | FAM228B | 0.613705 | 4 | 0 | 3 |
| SERGEF | PBXIP1 | 0.605419 | 5 | 0 | 5 |
| SERGEF | A2M-AS1 | 0.604264 | 4 | 0 | 3 |
| SERGEF | MRPL33 | 0.603638 | 3 | 0 | 3 |
| SERGEF | STK32A | 0.594985 | 3 | 0 | 3 |
| SERGEF | RPS6KA5 | 0.594799 | 5 | 0 | 4 |
For details and further investigation, click here
