| Full name: intersectin 1 | Alias Symbol: SH3P17|MGC134948|MGC134949 | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 6453 | HGNC ID: HGNC:6183 | Ensembl Gene: ENSG00000205726 | OMIM ID: 602442 |
| Drug and gene relationship at DGIdb | |||
Expression of ITSN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITSN1 | 6453 | 209297_at | -0.2347 | 0.5563 | |
| GSE20347 | ITSN1 | 6453 | 35776_at | -0.1213 | 0.1953 | |
| GSE23400 | ITSN1 | 6453 | 35776_at | -0.0586 | 0.2205 | |
| GSE26886 | ITSN1 | 6453 | 35776_at | -0.4265 | 0.0682 | |
| GSE29001 | ITSN1 | 6453 | 35776_at | -0.0894 | 0.8422 | |
| GSE38129 | ITSN1 | 6453 | 35776_at | -0.4706 | 0.0000 | |
| GSE45670 | ITSN1 | 6453 | 35776_at | -0.6339 | 0.0001 | |
| GSE53622 | ITSN1 | 6453 | 116235 | -0.3741 | 0.0000 | |
| GSE53624 | ITSN1 | 6453 | 116235 | -0.1180 | 0.0477 | |
| GSE63941 | ITSN1 | 6453 | 209297_at | -0.9153 | 0.1405 | |
| GSE77861 | ITSN1 | 6453 | 35776_at | -0.0311 | 0.8030 | |
| GSE97050 | ITSN1 | 6453 | A_33_P3250595 | -0.5591 | 0.1994 | |
| SRP007169 | ITSN1 | 6453 | RNAseq | -0.1856 | 0.6494 | |
| SRP008496 | ITSN1 | 6453 | RNAseq | -0.1431 | 0.5617 | |
| SRP064894 | ITSN1 | 6453 | RNAseq | 0.0306 | 0.8902 | |
| SRP133303 | ITSN1 | 6453 | RNAseq | -0.2955 | 0.1935 | |
| SRP159526 | ITSN1 | 6453 | RNAseq | -0.4060 | 0.0605 | |
| SRP193095 | ITSN1 | 6453 | RNAseq | -0.1088 | 0.3938 | |
| SRP219564 | ITSN1 | 6453 | RNAseq | -0.1966 | 0.6025 | |
| TCGA | ITSN1 | 6453 | RNAseq | -0.2280 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ITSN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITSN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITSN1 | 6453 | 2 | 7 | 21 | |
| GSE20123 | ITSN1 | 6453 | 2 | 8 | 20 | |
| GSE43470 | ITSN1 | 6453 | 1 | 11 | 31 | |
| GSE46452 | ITSN1 | 6453 | 1 | 21 | 37 | |
| GSE47630 | ITSN1 | 6453 | 6 | 17 | 17 | |
| GSE54993 | ITSN1 | 6453 | 9 | 1 | 60 | |
| GSE54994 | ITSN1 | 6453 | 1 | 9 | 43 | |
| GSE60625 | ITSN1 | 6453 | 0 | 0 | 11 | |
| GSE74703 | ITSN1 | 6453 | 1 | 8 | 27 | |
| GSE74704 | ITSN1 | 6453 | 1 | 4 | 15 | |
| TCGA | ITSN1 | 6453 | 8 | 36 | 52 |
Total number of gains: 32; Total number of losses: 122; Total Number of normals: 334.
Somatic mutations of ITSN1:
Generating mutation plots.
Highly correlated genes for ITSN1:
Showing top 20/544 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITSN1 | LRRC49 | 0.740355 | 3 | 0 | 3 |
| ITSN1 | RBPMS2 | 0.729394 | 4 | 0 | 4 |
| ITSN1 | PDK3 | 0.720862 | 3 | 0 | 3 |
| ITSN1 | DACT3 | 0.692562 | 6 | 0 | 5 |
| ITSN1 | ADCYAP1R1 | 0.690678 | 5 | 0 | 4 |
| ITSN1 | ZBTB20 | 0.681708 | 6 | 0 | 6 |
| ITSN1 | IGSF1 | 0.680699 | 3 | 0 | 3 |
| ITSN1 | PPP1R14A | 0.679487 | 5 | 0 | 4 |
| ITSN1 | KBTBD12 | 0.679086 | 4 | 0 | 3 |
| ITSN1 | TRAK2 | 0.670137 | 7 | 0 | 6 |
| ITSN1 | NEGR1 | 0.670058 | 5 | 0 | 4 |
| ITSN1 | PRUNE2 | 0.667954 | 7 | 0 | 7 |
| ITSN1 | TIMP3 | 0.665719 | 6 | 0 | 5 |
| ITSN1 | NEXN | 0.6603 | 6 | 0 | 5 |
| ITSN1 | MYOC | 0.659533 | 7 | 0 | 5 |
| ITSN1 | PGR | 0.65892 | 5 | 0 | 4 |
| ITSN1 | PARVA | 0.657428 | 7 | 0 | 5 |
| ITSN1 | RNF150 | 0.650547 | 4 | 0 | 4 |
| ITSN1 | ADAMTS5 | 0.650483 | 6 | 0 | 6 |
| ITSN1 | C1QTNF2 | 0.648262 | 4 | 0 | 3 |
For details and further investigation, click here
