| Full name: serpin family B member 8 | Alias Symbol: CAP2 | ||
| Type: protein-coding gene | Cytoband: 18q22.1 | ||
| Entrez ID: 5271 | HGNC ID: HGNC:8952 | Ensembl Gene: ENSG00000166401 | OMIM ID: 601697 |
| Drug and gene relationship at DGIdb | |||
Expression of SERPINB8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB8 | 5271 | 206034_at | -0.2651 | 0.7954 | |
| GSE20347 | SERPINB8 | 5271 | 206034_at | -0.8461 | 0.0000 | |
| GSE23400 | SERPINB8 | 5271 | 206034_at | -0.3536 | 0.0000 | |
| GSE26886 | SERPINB8 | 5271 | 206034_at | -1.4449 | 0.0000 | |
| GSE29001 | SERPINB8 | 5271 | 206034_at | -0.7497 | 0.0145 | |
| GSE38129 | SERPINB8 | 5271 | 206034_at | -0.4127 | 0.0646 | |
| GSE45670 | SERPINB8 | 5271 | 206034_at | 0.1344 | 0.5959 | |
| GSE53622 | SERPINB8 | 5271 | 83056 | -0.7937 | 0.0000 | |
| GSE53624 | SERPINB8 | 5271 | 83056 | -1.4232 | 0.0000 | |
| GSE63941 | SERPINB8 | 5271 | 206034_at | -1.2018 | 0.0232 | |
| GSE77861 | SERPINB8 | 5271 | 206034_at | -0.3265 | 0.2886 | |
| GSE97050 | SERPINB8 | 5271 | A_24_P147461 | 0.0511 | 0.9022 | |
| SRP007169 | SERPINB8 | 5271 | RNAseq | -2.3485 | 0.0000 | |
| SRP008496 | SERPINB8 | 5271 | RNAseq | -1.9349 | 0.0000 | |
| SRP064894 | SERPINB8 | 5271 | RNAseq | -0.8672 | 0.0018 | |
| SRP133303 | SERPINB8 | 5271 | RNAseq | -0.8854 | 0.0000 | |
| SRP159526 | SERPINB8 | 5271 | RNAseq | -0.9938 | 0.0398 | |
| SRP193095 | SERPINB8 | 5271 | RNAseq | -0.8543 | 0.0000 | |
| SRP219564 | SERPINB8 | 5271 | RNAseq | -1.8351 | 0.0026 | |
| TCGA | SERPINB8 | 5271 | RNAseq | 0.0495 | 0.5895 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by SERPINB8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB8 | 5271 | 1 | 9 | 20 | |
| GSE20123 | SERPINB8 | 5271 | 1 | 9 | 20 | |
| GSE43470 | SERPINB8 | 5271 | 0 | 7 | 36 | |
| GSE46452 | SERPINB8 | 5271 | 1 | 26 | 32 | |
| GSE47630 | SERPINB8 | 5271 | 5 | 21 | 14 | |
| GSE54993 | SERPINB8 | 5271 | 9 | 0 | 61 | |
| GSE54994 | SERPINB8 | 5271 | 1 | 18 | 34 | |
| GSE60625 | SERPINB8 | 5271 | 0 | 4 | 7 | |
| GSE74703 | SERPINB8 | 5271 | 0 | 7 | 29 | |
| GSE74704 | SERPINB8 | 5271 | 1 | 6 | 13 | |
| TCGA | SERPINB8 | 5271 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB8:
Generating mutation plots.
Highly correlated genes for SERPINB8:
Showing top 20/1227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB8 | CCDC25 | 0.769092 | 3 | 0 | 3 |
| SERPINB8 | APPL2 | 0.765288 | 3 | 0 | 3 |
| SERPINB8 | WDR36 | 0.763963 | 3 | 0 | 3 |
| SERPINB8 | SH3PXD2A-AS1 | 0.761641 | 3 | 0 | 3 |
| SERPINB8 | KCTD21 | 0.758768 | 3 | 0 | 3 |
| SERPINB8 | AGGF1 | 0.747516 | 3 | 0 | 3 |
| SERPINB8 | PAQR7 | 0.743752 | 3 | 0 | 3 |
| SERPINB8 | VPS4B | 0.738074 | 12 | 0 | 11 |
| SERPINB8 | VPS25 | 0.731167 | 6 | 0 | 6 |
| SERPINB8 | STAMBP | 0.727525 | 3 | 0 | 3 |
| SERPINB8 | SERPINB2 | 0.727318 | 11 | 0 | 10 |
| SERPINB8 | BCL10 | 0.71918 | 9 | 0 | 8 |
| SERPINB8 | EPGN | 0.713641 | 3 | 0 | 3 |
| SERPINB8 | THAP2 | 0.711185 | 4 | 0 | 4 |
| SERPINB8 | FAHD1 | 0.710937 | 5 | 0 | 5 |
| SERPINB8 | TGM1 | 0.708635 | 12 | 0 | 12 |
| SERPINB8 | ARPC1A | 0.705995 | 3 | 0 | 3 |
| SERPINB8 | TRIB3 | 0.705656 | 3 | 0 | 3 |
| SERPINB8 | SIAE | 0.705646 | 6 | 0 | 6 |
| SERPINB8 | AMOTL1 | 0.704894 | 3 | 0 | 3 |
For details and further investigation, click here
