TRIB3

 

Full name: tribbles pseudokinase 3 Alias Symbol: dJ1103G7.3|TRB3
Type: protein-coding gene Cytoband: 20p13
Entrez ID: 57761 HGNC ID: HGNC:16228 Ensembl Gene: ENSG00000101255 OMIM ID: 607898
Drug and gene relationship at DGIdb

 

TRIB3 involved pathways:

KEGG pathway Description View
hsa04931Insulin resistance

 

Expression of TRIB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRIB3 57761 218145_at -0.1675 0.8859
GSE20347 TRIB3 57761 218145_at 0.0532 0.8819
GSE23400 TRIB3 57761 218145_at 0.0136 0.8986
GSE26886 TRIB3 57761 218145_at 0.2216 0.4656
GSE29001 TRIB3 57761 218145_at 0.1376 0.6379
GSE38129 TRIB3 57761 218145_at 0.6889 0.0083
GSE45670 TRIB3 57761 218145_at 0.2887 0.3762
GSE53622 TRIB3 57761 16118 0.2232 0.2008
GSE53624 TRIB3 57761 16118 0.4672 0.0000
GSE63941 TRIB3 57761 218145_at 1.0518 0.4557
GSE77861 TRIB3 57761 218145_at 0.0367 0.9146
GSE97050 TRIB3 57761 A_23_P210690 0.5571 0.3688
SRP007169 TRIB3 57761 RNAseq -1.0247 0.1100
SRP008496 TRIB3 57761 RNAseq -0.7638 0.0699
SRP064894 TRIB3 57761 RNAseq 0.6772 0.0246
SRP133303 TRIB3 57761 RNAseq 1.1508 0.0083
SRP159526 TRIB3 57761 RNAseq 0.3840 0.2042
SRP193095 TRIB3 57761 RNAseq 1.3247 0.0000
SRP219564 TRIB3 57761 RNAseq 0.6791 0.3121
TCGA TRIB3 57761 RNAseq 0.6117 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TRIB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TRIB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRIB3 57761 12 4 14
GSE20123 TRIB3 57761 13 4 13
GSE43470 TRIB3 57761 11 1 31
GSE46452 TRIB3 57761 26 1 32
GSE47630 TRIB3 57761 19 4 17
GSE54993 TRIB3 57761 2 15 53
GSE54994 TRIB3 57761 24 2 27
GSE60625 TRIB3 57761 0 0 11
GSE74703 TRIB3 57761 10 1 25
GSE74704 TRIB3 57761 8 2 10
TCGA TRIB3 57761 41 11 44

Total number of gains: 166; Total number of losses: 45; Total Number of normals: 277.  

 

Somatic mutations of TRIB3:

 

Generating mutation plots.

 

Highly correlated genes for TRIB3:

 

Showing top 20/123 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRIB3LAMP20.763785303
TRIB3NRAS0.735328404
TRIB3PPP2R2A0.719749303
TRIB3EPN10.707952303
TRIB3SERPINB80.705656303
TRIB3YY10.702475303
TRIB3BDKRB20.69802303
TRIB3RNF1450.68248303
TRIB3FRMD4B0.677347303
TRIB3PCGF20.676028303
TRIB3UNK0.675286303
TRIB3GSPT10.669242303
TRIB3STAMBP0.66763403
TRIB3GRPEL20.666203403
TRIB3SPTSSB0.665338303
TRIB3SERINC20.664444303
TRIB3SESN20.650928403
TRIB3DUSP110.650533303
TRIB3PTPN120.649959403
TRIB3CREB50.64868303

For details and further investigation, click here