| Full name: serpin family B member 2 | Alias Symbol: HsT1201 | ||
| Type: protein-coding gene | Cytoband: 18q21.33-q22.1 | ||
| Entrez ID: 5055 | HGNC ID: HGNC:8584 | Ensembl Gene: ENSG00000197632 | OMIM ID: 173390 |
| Drug and gene relationship at DGIdb | |||
SERPINB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of SERPINB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINB2 | 5055 | 204614_at | -1.8173 | 0.4969 | |
| GSE20347 | SERPINB2 | 5055 | 204614_at | -3.7595 | 0.0000 | |
| GSE23400 | SERPINB2 | 5055 | 204614_at | -2.5896 | 0.0000 | |
| GSE26886 | SERPINB2 | 5055 | 204614_at | -6.1236 | 0.0000 | |
| GSE29001 | SERPINB2 | 5055 | 204614_at | -3.0913 | 0.0008 | |
| GSE38129 | SERPINB2 | 5055 | 204614_at | -2.5125 | 0.0019 | |
| GSE45670 | SERPINB2 | 5055 | 204614_at | -1.3839 | 0.0032 | |
| GSE53622 | SERPINB2 | 5055 | 75540 | -2.8909 | 0.0000 | |
| GSE53624 | SERPINB2 | 5055 | 75540 | -3.7167 | 0.0000 | |
| GSE63941 | SERPINB2 | 5055 | 204614_at | 0.2161 | 0.9245 | |
| GSE77861 | SERPINB2 | 5055 | 204614_at | -3.1378 | 0.0205 | |
| GSE97050 | SERPINB2 | 5055 | A_24_P245379 | -1.1100 | 0.6296 | |
| SRP007169 | SERPINB2 | 5055 | RNAseq | -4.2415 | 0.0000 | |
| SRP008496 | SERPINB2 | 5055 | RNAseq | -4.7000 | 0.0000 | |
| SRP064894 | SERPINB2 | 5055 | RNAseq | -4.1828 | 0.0000 | |
| SRP133303 | SERPINB2 | 5055 | RNAseq | -2.6957 | 0.0000 | |
| SRP159526 | SERPINB2 | 5055 | RNAseq | -4.7150 | 0.0000 | |
| SRP219564 | SERPINB2 | 5055 | RNAseq | -4.9068 | 0.0001 | |
| TCGA | SERPINB2 | 5055 | RNAseq | 0.8365 | 0.0232 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by SERPINB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINB2 | 5055 | 1 | 9 | 20 | |
| GSE20123 | SERPINB2 | 5055 | 1 | 9 | 20 | |
| GSE43470 | SERPINB2 | 5055 | 0 | 7 | 36 | |
| GSE46452 | SERPINB2 | 5055 | 1 | 26 | 32 | |
| GSE47630 | SERPINB2 | 5055 | 5 | 21 | 14 | |
| GSE54993 | SERPINB2 | 5055 | 9 | 0 | 61 | |
| GSE54994 | SERPINB2 | 5055 | 1 | 18 | 34 | |
| GSE60625 | SERPINB2 | 5055 | 0 | 4 | 7 | |
| GSE74703 | SERPINB2 | 5055 | 0 | 7 | 29 | |
| GSE74704 | SERPINB2 | 5055 | 1 | 6 | 13 | |
| TCGA | SERPINB2 | 5055 | 10 | 45 | 41 |
Total number of gains: 29; Total number of losses: 152; Total Number of normals: 307.
Somatic mutations of SERPINB2:
Generating mutation plots.
Highly correlated genes for SERPINB2:
Showing top 20/1354 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINB2 | ANXA1 | 0.846588 | 12 | 0 | 12 |
| SERPINB2 | SCEL | 0.840345 | 12 | 0 | 12 |
| SERPINB2 | SERPINB13 | 0.829901 | 12 | 0 | 11 |
| SERPINB2 | CSTB | 0.826512 | 12 | 0 | 12 |
| SERPINB2 | MALL | 0.817857 | 12 | 0 | 12 |
| SERPINB2 | PPL | 0.816597 | 12 | 0 | 12 |
| SERPINB2 | IL18 | 0.808622 | 11 | 0 | 11 |
| SERPINB2 | TMPRSS11E | 0.805962 | 11 | 0 | 11 |
| SERPINB2 | CYSRT1 | 0.802972 | 6 | 0 | 6 |
| SERPINB2 | C1orf116 | 0.802034 | 12 | 0 | 12 |
| SERPINB2 | RHCG | 0.800309 | 11 | 0 | 11 |
| SERPINB2 | EMP1 | 0.799604 | 12 | 0 | 11 |
| SERPINB2 | IL1RN | 0.798774 | 13 | 0 | 12 |
| SERPINB2 | CRCT1 | 0.798129 | 12 | 0 | 12 |
| SERPINB2 | RAB11A | 0.795865 | 10 | 0 | 10 |
| SERPINB2 | TTC9 | 0.791006 | 10 | 0 | 10 |
| SERPINB2 | SERPINB1 | 0.789822 | 12 | 0 | 12 |
| SERPINB2 | CSTA | 0.786452 | 10 | 0 | 10 |
| SERPINB2 | VPS4B | 0.781771 | 11 | 0 | 11 |
| SERPINB2 | TMOD3 | 0.780684 | 12 | 0 | 11 |
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