| Full name: serum response factor binding protein 1 | Alias Symbol: FLJ25286|p49|STRAP|BUD22|Rlb1 | ||
| Type: protein-coding gene | Cytoband: 5q23.1 | ||
| Entrez ID: 153443 | HGNC ID: HGNC:26333 | Ensembl Gene: ENSG00000151304 | OMIM ID: 610479 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRFBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRFBP1 | 153443 | 241734_at | 0.1187 | 0.8690 | |
| GSE26886 | SRFBP1 | 153443 | 241734_at | 0.2761 | 0.2130 | |
| GSE45670 | SRFBP1 | 153443 | 241734_at | 0.0434 | 0.8595 | |
| GSE53622 | SRFBP1 | 153443 | 122217 | -0.2025 | 0.0011 | |
| GSE53624 | SRFBP1 | 153443 | 122217 | 0.0160 | 0.8660 | |
| GSE63941 | SRFBP1 | 153443 | 241734_at | 0.8785 | 0.0534 | |
| GSE77861 | SRFBP1 | 153443 | 241734_at | -0.0548 | 0.8565 | |
| GSE97050 | SRFBP1 | 153443 | A_23_P435002 | 0.0262 | 0.9096 | |
| SRP007169 | SRFBP1 | 153443 | RNAseq | -0.2946 | 0.4854 | |
| SRP008496 | SRFBP1 | 153443 | RNAseq | -0.2262 | 0.4680 | |
| SRP064894 | SRFBP1 | 153443 | RNAseq | -0.2016 | 0.4376 | |
| SRP133303 | SRFBP1 | 153443 | RNAseq | 0.3861 | 0.0109 | |
| SRP159526 | SRFBP1 | 153443 | RNAseq | -0.1496 | 0.7194 | |
| SRP193095 | SRFBP1 | 153443 | RNAseq | -0.1674 | 0.0608 | |
| SRP219564 | SRFBP1 | 153443 | RNAseq | 0.1439 | 0.7458 | |
| TCGA | SRFBP1 | 153443 | RNAseq | 0.0935 | 0.1458 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRFBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SRFBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRFBP1 | 153443 | 1 | 13 | 16 | |
| GSE20123 | SRFBP1 | 153443 | 1 | 13 | 16 | |
| GSE43470 | SRFBP1 | 153443 | 3 | 8 | 32 | |
| GSE46452 | SRFBP1 | 153443 | 0 | 27 | 32 | |
| GSE47630 | SRFBP1 | 153443 | 0 | 21 | 19 | |
| GSE54993 | SRFBP1 | 153443 | 9 | 1 | 60 | |
| GSE54994 | SRFBP1 | 153443 | 2 | 14 | 37 | |
| GSE60625 | SRFBP1 | 153443 | 0 | 0 | 11 | |
| GSE74703 | SRFBP1 | 153443 | 2 | 6 | 28 | |
| GSE74704 | SRFBP1 | 153443 | 1 | 7 | 12 | |
| TCGA | SRFBP1 | 153443 | 3 | 40 | 53 |
Total number of gains: 22; Total number of losses: 150; Total Number of normals: 316.
Somatic mutations of SRFBP1:
Generating mutation plots.
Highly correlated genes for SRFBP1:
Showing top 20/294 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRFBP1 | PSMC1 | 0.771839 | 3 | 0 | 3 |
| SRFBP1 | THUMPD1 | 0.766088 | 3 | 0 | 3 |
| SRFBP1 | GTF2H3 | 0.761436 | 3 | 0 | 3 |
| SRFBP1 | PANK3 | 0.733868 | 3 | 0 | 3 |
| SRFBP1 | SGPP1 | 0.73369 | 4 | 0 | 4 |
| SRFBP1 | MTRF1L | 0.730513 | 3 | 0 | 3 |
| SRFBP1 | ERCC4 | 0.721152 | 3 | 0 | 3 |
| SRFBP1 | CLASP2 | 0.718624 | 3 | 0 | 3 |
| SRFBP1 | CYCS | 0.718165 | 4 | 0 | 4 |
| SRFBP1 | GFM2 | 0.716907 | 3 | 0 | 3 |
| SRFBP1 | AIMP1 | 0.714556 | 3 | 0 | 3 |
| SRFBP1 | KIAA0586 | 0.710929 | 3 | 0 | 3 |
| SRFBP1 | SMG8 | 0.706957 | 3 | 0 | 3 |
| SRFBP1 | MTSS1 | 0.70652 | 3 | 0 | 3 |
| SRFBP1 | MTO1 | 0.704226 | 4 | 0 | 4 |
| SRFBP1 | VBP1 | 0.703517 | 3 | 0 | 3 |
| SRFBP1 | CCDC126 | 0.702989 | 4 | 0 | 4 |
| SRFBP1 | ATG10 | 0.69891 | 5 | 0 | 4 |
| SRFBP1 | ZW10 | 0.698876 | 3 | 0 | 3 |
| SRFBP1 | RUFY2 | 0.698793 | 3 | 0 | 3 |
For details and further investigation, click here
