| Full name: SH2 domain containing 4A | Alias Symbol: FLJ20967|SH2A|PPP1R38 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 63898 | HGNC ID: HGNC:26102 | Ensembl Gene: ENSG00000104611 | OMIM ID: 614968 |
| Drug and gene relationship at DGIdb | |||
Expression of SH2D4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D4A | 63898 | 219749_at | -0.2966 | 0.7828 | |
| GSE20347 | SH2D4A | 63898 | 219749_at | -0.3122 | 0.0097 | |
| GSE23400 | SH2D4A | 63898 | 219749_at | -0.2588 | 0.0000 | |
| GSE26886 | SH2D4A | 63898 | 219749_at | -0.9058 | 0.0000 | |
| GSE29001 | SH2D4A | 63898 | 219749_at | -0.5205 | 0.0543 | |
| GSE38129 | SH2D4A | 63898 | 219749_at | -0.2572 | 0.1253 | |
| GSE45670 | SH2D4A | 63898 | 219749_at | 0.0309 | 0.8954 | |
| GSE53622 | SH2D4A | 63898 | 63745 | -0.9603 | 0.0000 | |
| GSE53624 | SH2D4A | 63898 | 63745 | -1.2724 | 0.0000 | |
| GSE63941 | SH2D4A | 63898 | 219749_at | -1.3894 | 0.0524 | |
| GSE77861 | SH2D4A | 63898 | 219749_at | -0.1565 | 0.2274 | |
| GSE97050 | SH2D4A | 63898 | A_23_P169003 | 0.3961 | 0.4950 | |
| SRP007169 | SH2D4A | 63898 | RNAseq | -1.5125 | 0.0008 | |
| SRP008496 | SH2D4A | 63898 | RNAseq | -1.5481 | 0.0000 | |
| SRP064894 | SH2D4A | 63898 | RNAseq | -1.4953 | 0.0000 | |
| SRP133303 | SH2D4A | 63898 | RNAseq | -1.3364 | 0.0000 | |
| SRP159526 | SH2D4A | 63898 | RNAseq | -1.6384 | 0.0000 | |
| SRP193095 | SH2D4A | 63898 | RNAseq | -1.0995 | 0.0000 | |
| SRP219564 | SH2D4A | 63898 | RNAseq | -1.5440 | 0.0329 | |
| TCGA | SH2D4A | 63898 | RNAseq | -0.3097 | 0.0032 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SH2D4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D4A | 63898 | 4 | 9 | 17 | |
| GSE20123 | SH2D4A | 63898 | 4 | 9 | 17 | |
| GSE43470 | SH2D4A | 63898 | 4 | 8 | 31 | |
| GSE46452 | SH2D4A | 63898 | 14 | 13 | 32 | |
| GSE47630 | SH2D4A | 63898 | 10 | 8 | 22 | |
| GSE54993 | SH2D4A | 63898 | 2 | 14 | 54 | |
| GSE54994 | SH2D4A | 63898 | 8 | 18 | 27 | |
| GSE60625 | SH2D4A | 63898 | 3 | 0 | 8 | |
| GSE74703 | SH2D4A | 63898 | 4 | 7 | 25 | |
| GSE74704 | SH2D4A | 63898 | 3 | 6 | 11 | |
| TCGA | SH2D4A | 63898 | 14 | 41 | 41 |
Total number of gains: 70; Total number of losses: 133; Total Number of normals: 285.
Somatic mutations of SH2D4A:
Generating mutation plots.
Highly correlated genes for SH2D4A:
Showing top 20/1102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D4A | EIF2AK3 | 0.755985 | 3 | 0 | 3 |
| SH2D4A | SORD | 0.73956 | 3 | 0 | 3 |
| SH2D4A | TLE4 | 0.730479 | 3 | 0 | 3 |
| SH2D4A | RBM20 | 0.727031 | 3 | 0 | 3 |
| SH2D4A | EPS15 | 0.727009 | 4 | 0 | 3 |
| SH2D4A | ZNF101 | 0.72682 | 5 | 0 | 5 |
| SH2D4A | WDFY1 | 0.724044 | 4 | 0 | 4 |
| SH2D4A | C6orf120 | 0.722882 | 3 | 0 | 3 |
| SH2D4A | LIPH | 0.715363 | 6 | 0 | 5 |
| SH2D4A | ZNF416 | 0.711932 | 3 | 0 | 3 |
| SH2D4A | ELF3 | 0.709549 | 10 | 0 | 10 |
| SH2D4A | PRPF38A | 0.706326 | 3 | 0 | 3 |
| SH2D4A | NHSL1 | 0.701472 | 5 | 0 | 5 |
| SH2D4A | TAB3 | 0.698417 | 6 | 0 | 6 |
| SH2D4A | LTA4H | 0.698085 | 3 | 0 | 3 |
| SH2D4A | ELOVL1 | 0.697755 | 3 | 0 | 3 |
| SH2D4A | SLC10A5 | 0.693072 | 3 | 0 | 3 |
| SH2D4A | NIPAL1 | 0.691454 | 3 | 0 | 3 |
| SH2D4A | NAPRT | 0.69103 | 3 | 0 | 3 |
| SH2D4A | RBM47 | 0.688934 | 11 | 0 | 9 |
For details and further investigation, click here
