| Full name: eukaryotic translation initiation factor 2 alpha kinase 3 | Alias Symbol: PEK|PERK | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 9451 | HGNC ID: HGNC:3255 | Ensembl Gene: ENSG00000172071 | OMIM ID: 604032 |
| Drug and gene relationship at DGIdb | |||
EIF2AK3 involved pathways:
Expression of EIF2AK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2AK3 | 9451 | 218696_at | -0.0917 | 0.7969 | |
| GSE20347 | EIF2AK3 | 9451 | 218696_at | 0.0205 | 0.9140 | |
| GSE23400 | EIF2AK3 | 9451 | 218696_at | 0.2164 | 0.0155 | |
| GSE26886 | EIF2AK3 | 9451 | 218696_at | -0.0430 | 0.8781 | |
| GSE29001 | EIF2AK3 | 9451 | 218696_at | -0.1832 | 0.6431 | |
| GSE38129 | EIF2AK3 | 9451 | 218696_at | 0.1625 | 0.2637 | |
| GSE45670 | EIF2AK3 | 9451 | 218696_at | 0.1487 | 0.5297 | |
| GSE53622 | EIF2AK3 | 9451 | 32614 | 0.2882 | 0.0098 | |
| GSE53624 | EIF2AK3 | 9451 | 32614 | -0.0737 | 0.4522 | |
| GSE63941 | EIF2AK3 | 9451 | 218696_at | -0.4358 | 0.1999 | |
| GSE77861 | EIF2AK3 | 9451 | 218696_at | -0.0531 | 0.9219 | |
| GSE97050 | EIF2AK3 | 9451 | A_23_P135857 | 0.2660 | 0.2816 | |
| SRP007169 | EIF2AK3 | 9451 | RNAseq | 1.0425 | 0.0226 | |
| SRP008496 | EIF2AK3 | 9451 | RNAseq | 0.7935 | 0.0086 | |
| SRP064894 | EIF2AK3 | 9451 | RNAseq | -0.2411 | 0.3389 | |
| SRP133303 | EIF2AK3 | 9451 | RNAseq | 0.5057 | 0.0346 | |
| SRP159526 | EIF2AK3 | 9451 | RNAseq | 0.4381 | 0.0633 | |
| SRP193095 | EIF2AK3 | 9451 | RNAseq | -0.2812 | 0.1326 | |
| SRP219564 | EIF2AK3 | 9451 | RNAseq | 0.5719 | 0.0850 | |
| TCGA | EIF2AK3 | 9451 | RNAseq | -0.3108 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EIF2AK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2AK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2AK3 | 9451 | 9 | 3 | 18 | |
| GSE20123 | EIF2AK3 | 9451 | 9 | 3 | 18 | |
| GSE43470 | EIF2AK3 | 9451 | 2 | 2 | 39 | |
| GSE46452 | EIF2AK3 | 9451 | 2 | 3 | 54 | |
| GSE47630 | EIF2AK3 | 9451 | 7 | 0 | 33 | |
| GSE54993 | EIF2AK3 | 9451 | 0 | 6 | 64 | |
| GSE54994 | EIF2AK3 | 9451 | 10 | 0 | 43 | |
| GSE60625 | EIF2AK3 | 9451 | 0 | 3 | 8 | |
| GSE74703 | EIF2AK3 | 9451 | 2 | 1 | 33 | |
| GSE74704 | EIF2AK3 | 9451 | 7 | 0 | 13 | |
| TCGA | EIF2AK3 | 9451 | 34 | 4 | 58 |
Total number of gains: 82; Total number of losses: 25; Total Number of normals: 381.
Somatic mutations of EIF2AK3:
Generating mutation plots.
Highly correlated genes for EIF2AK3:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2AK3 | SH2D4A | 0.755985 | 3 | 0 | 3 |
| EIF2AK3 | CASP3 | 0.70636 | 4 | 0 | 4 |
| EIF2AK3 | OGFRL1 | 0.704573 | 3 | 0 | 3 |
| EIF2AK3 | MIEN1 | 0.697527 | 3 | 0 | 3 |
| EIF2AK3 | FRAT1 | 0.693885 | 3 | 0 | 3 |
| EIF2AK3 | SURF1 | 0.689674 | 3 | 0 | 3 |
| EIF2AK3 | C21orf91 | 0.676409 | 3 | 0 | 3 |
| EIF2AK3 | IL10RB | 0.674529 | 4 | 0 | 4 |
| EIF2AK3 | SGMS1 | 0.674367 | 3 | 0 | 3 |
| EIF2AK3 | GTF3C1 | 0.66511 | 3 | 0 | 3 |
| EIF2AK3 | RPS27A | 0.663022 | 3 | 0 | 3 |
| EIF2AK3 | AP1B1 | 0.659599 | 3 | 0 | 3 |
| EIF2AK3 | CUL3 | 0.658942 | 3 | 0 | 3 |
| EIF2AK3 | FAM102A | 0.656485 | 3 | 0 | 3 |
| EIF2AK3 | PARN | 0.654238 | 3 | 0 | 3 |
| EIF2AK3 | CDC23 | 0.652792 | 3 | 0 | 3 |
| EIF2AK3 | DLG3 | 0.650045 | 3 | 0 | 3 |
| EIF2AK3 | USP24 | 0.649521 | 3 | 0 | 3 |
| EIF2AK3 | CRADD | 0.647066 | 4 | 0 | 4 |
| EIF2AK3 | HAUS1 | 0.645406 | 3 | 0 | 3 |
For details and further investigation, click here
