| Full name: splicing factor 3b subunit 4 | Alias Symbol: SAP49|SF3b49|Hsh49 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 10262 | HGNC ID: HGNC:10771 | Ensembl Gene: ENSG00000143368 | OMIM ID: 605593 |
| Drug and gene relationship at DGIdb | |||
Expression of SF3B4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SF3B4 | 10262 | 209044_x_at | 0.6662 | 0.0405 | |
| GSE20347 | SF3B4 | 10262 | 209044_x_at | 0.6517 | 0.0000 | |
| GSE23400 | SF3B4 | 10262 | 209044_x_at | 0.6588 | 0.0000 | |
| GSE26886 | SF3B4 | 10262 | 209044_x_at | 0.7104 | 0.0020 | |
| GSE29001 | SF3B4 | 10262 | 209044_x_at | 0.3213 | 0.2942 | |
| GSE38129 | SF3B4 | 10262 | 209044_x_at | 0.7400 | 0.0000 | |
| GSE45670 | SF3B4 | 10262 | 209044_x_at | 0.4881 | 0.0001 | |
| GSE53622 | SF3B4 | 10262 | 38857 | 0.3699 | 0.0000 | |
| GSE53624 | SF3B4 | 10262 | 38857 | 0.7097 | 0.0000 | |
| GSE63941 | SF3B4 | 10262 | 209044_x_at | 1.4858 | 0.0000 | |
| GSE77861 | SF3B4 | 10262 | 209044_x_at | 0.7460 | 0.0152 | |
| GSE97050 | SF3B4 | 10262 | A_23_P35131 | 0.3295 | 0.2622 | |
| SRP007169 | SF3B4 | 10262 | RNAseq | 0.0623 | 0.8470 | |
| SRP008496 | SF3B4 | 10262 | RNAseq | 0.1699 | 0.5290 | |
| SRP064894 | SF3B4 | 10262 | RNAseq | 0.4101 | 0.0196 | |
| SRP133303 | SF3B4 | 10262 | RNAseq | 0.4377 | 0.0039 | |
| SRP159526 | SF3B4 | 10262 | RNAseq | 0.6741 | 0.0000 | |
| SRP193095 | SF3B4 | 10262 | RNAseq | 0.4637 | 0.0001 | |
| SRP219564 | SF3B4 | 10262 | RNAseq | 0.5897 | 0.1096 | |
| TCGA | SF3B4 | 10262 | RNAseq | 0.2656 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SF3B4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SF3B4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SF3B4 | 10262 | 15 | 0 | 15 | |
| GSE20123 | SF3B4 | 10262 | 15 | 0 | 15 | |
| GSE43470 | SF3B4 | 10262 | 6 | 1 | 36 | |
| GSE46452 | SF3B4 | 10262 | 2 | 1 | 56 | |
| GSE47630 | SF3B4 | 10262 | 14 | 0 | 26 | |
| GSE54993 | SF3B4 | 10262 | 0 | 3 | 67 | |
| GSE54994 | SF3B4 | 10262 | 15 | 0 | 38 | |
| GSE60625 | SF3B4 | 10262 | 0 | 0 | 11 | |
| GSE74703 | SF3B4 | 10262 | 6 | 1 | 29 | |
| GSE74704 | SF3B4 | 10262 | 7 | 0 | 13 | |
| TCGA | SF3B4 | 10262 | 37 | 4 | 55 |
Total number of gains: 117; Total number of losses: 10; Total Number of normals: 361.
Somatic mutations of SF3B4:
Generating mutation plots.
Highly correlated genes for SF3B4:
Showing top 20/1698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SF3B4 | YWHAG | 0.794758 | 4 | 0 | 4 |
| SF3B4 | SHANK3 | 0.764342 | 3 | 0 | 3 |
| SF3B4 | TMEM63B | 0.763954 | 4 | 0 | 4 |
| SF3B4 | SLC39A3 | 0.759738 | 4 | 0 | 4 |
| SF3B4 | NACC1 | 0.748641 | 5 | 0 | 5 |
| SF3B4 | PACS1 | 0.746204 | 4 | 0 | 4 |
| SF3B4 | CHCHD5 | 0.741589 | 3 | 0 | 3 |
| SF3B4 | GTF2H3 | 0.739845 | 3 | 0 | 3 |
| SF3B4 | PRCC | 0.735279 | 11 | 0 | 10 |
| SF3B4 | TMTC4 | 0.730132 | 3 | 0 | 3 |
| SF3B4 | HMGB1 | 0.729696 | 5 | 0 | 5 |
| SF3B4 | RPA1 | 0.728964 | 7 | 0 | 7 |
| SF3B4 | UBAP2L | 0.724039 | 11 | 0 | 9 |
| SF3B4 | ITGB4 | 0.718681 | 10 | 0 | 10 |
| SF3B4 | KRTCAP2 | 0.718592 | 5 | 0 | 5 |
| SF3B4 | ARHGAP39 | 0.717438 | 3 | 0 | 3 |
| SF3B4 | ARF3 | 0.713357 | 3 | 0 | 3 |
| SF3B4 | KCNAB2 | 0.711317 | 3 | 0 | 3 |
| SF3B4 | BUB1 | 0.710407 | 10 | 0 | 10 |
| SF3B4 | MCCC2 | 0.706767 | 3 | 0 | 3 |
For details and further investigation, click here
