| Full name: dolichol kinase | Alias Symbol: KIAA1094|DK1 | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 22845 | HGNC ID: HGNC:23406 | Ensembl Gene: ENSG00000175283 | OMIM ID: 610746 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DOLK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DOLK | 22845 | 204488_at | 0.3975 | 0.2033 | |
| GSE20347 | DOLK | 22845 | 204488_at | 0.0879 | 0.6085 | |
| GSE23400 | DOLK | 22845 | 204488_at | 0.2681 | 0.0000 | |
| GSE26886 | DOLK | 22845 | 204488_at | -0.0407 | 0.8635 | |
| GSE29001 | DOLK | 22845 | 204488_at | 0.0822 | 0.6731 | |
| GSE38129 | DOLK | 22845 | 204488_at | 0.1989 | 0.0673 | |
| GSE45670 | DOLK | 22845 | 204488_at | 0.2486 | 0.0639 | |
| GSE53622 | DOLK | 22845 | 24298 | 0.4884 | 0.0000 | |
| GSE53624 | DOLK | 22845 | 24298 | 0.6006 | 0.0000 | |
| GSE63941 | DOLK | 22845 | 204488_at | -0.4838 | 0.2617 | |
| GSE77861 | DOLK | 22845 | 204488_at | 0.3130 | 0.0372 | |
| GSE97050 | DOLK | 22845 | A_23_P10870 | 0.4529 | 0.1403 | |
| SRP007169 | DOLK | 22845 | RNAseq | 0.3807 | 0.3779 | |
| SRP008496 | DOLK | 22845 | RNAseq | 0.4379 | 0.0577 | |
| SRP064894 | DOLK | 22845 | RNAseq | 0.6574 | 0.0032 | |
| SRP133303 | DOLK | 22845 | RNAseq | 0.4941 | 0.0056 | |
| SRP159526 | DOLK | 22845 | RNAseq | 0.6767 | 0.0000 | |
| SRP193095 | DOLK | 22845 | RNAseq | 0.3135 | 0.0168 | |
| SRP219564 | DOLK | 22845 | RNAseq | 0.2665 | 0.3152 | |
| TCGA | DOLK | 22845 | RNAseq | 0.0658 | 0.2997 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DOLK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DOLK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DOLK | 22845 | 6 | 9 | 15 | |
| GSE20123 | DOLK | 22845 | 6 | 9 | 15 | |
| GSE43470 | DOLK | 22845 | 5 | 8 | 30 | |
| GSE46452 | DOLK | 22845 | 6 | 13 | 40 | |
| GSE47630 | DOLK | 22845 | 3 | 16 | 21 | |
| GSE54993 | DOLK | 22845 | 3 | 3 | 64 | |
| GSE54994 | DOLK | 22845 | 11 | 8 | 34 | |
| GSE60625 | DOLK | 22845 | 0 | 0 | 11 | |
| GSE74703 | DOLK | 22845 | 5 | 6 | 25 | |
| GSE74704 | DOLK | 22845 | 3 | 7 | 10 | |
| TCGA | DOLK | 22845 | 27 | 24 | 45 |
Total number of gains: 75; Total number of losses: 103; Total Number of normals: 310.
Somatic mutations of DOLK:
Generating mutation plots.
Highly correlated genes for DOLK:
Showing top 20/980 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DOLK | PPP1R9B | 0.79043 | 3 | 0 | 3 |
| DOLK | IRF2BPL | 0.772313 | 3 | 0 | 3 |
| DOLK | DUSP7 | 0.767115 | 3 | 0 | 3 |
| DOLK | DEDD | 0.752304 | 3 | 0 | 3 |
| DOLK | LRIG2 | 0.748016 | 3 | 0 | 3 |
| DOLK | SHANK3 | 0.740844 | 3 | 0 | 3 |
| DOLK | SPATA5 | 0.737241 | 3 | 0 | 3 |
| DOLK | UBTD2 | 0.719037 | 3 | 0 | 3 |
| DOLK | ORAI1 | 0.714022 | 4 | 0 | 4 |
| DOLK | TTLL1 | 0.712666 | 3 | 0 | 3 |
| DOLK | TPM3 | 0.710894 | 5 | 0 | 5 |
| DOLK | RTKN | 0.709418 | 5 | 0 | 4 |
| DOLK | MEF2A | 0.70542 | 3 | 0 | 3 |
| DOLK | TIGD1 | 0.695461 | 3 | 0 | 3 |
| DOLK | DOCK6 | 0.692111 | 3 | 0 | 3 |
| DOLK | EP400 | 0.686936 | 3 | 0 | 3 |
| DOLK | EBNA1BP2 | 0.684705 | 3 | 0 | 3 |
| DOLK | SLC44A1 | 0.680984 | 7 | 0 | 7 |
| DOLK | DGCR2 | 0.674924 | 3 | 0 | 3 |
| DOLK | ZNF707 | 0.674637 | 3 | 0 | 3 |
For details and further investigation, click here
