| Full name: actin related protein 8 | Alias Symbol: INO80N|ARP8 | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 93973 | HGNC ID: HGNC:14672 | Ensembl Gene: ENSG00000113812 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACTR8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTR8 | 93973 | 222707_s_at | -0.0133 | 0.9628 | |
| GSE20347 | ACTR8 | 93973 | 218658_s_at | -0.3133 | 0.0000 | |
| GSE23400 | ACTR8 | 93973 | 218658_s_at | -0.0889 | 0.0012 | |
| GSE26886 | ACTR8 | 93973 | 222707_s_at | -0.4434 | 0.0000 | |
| GSE29001 | ACTR8 | 93973 | 218658_s_at | -0.2262 | 0.3592 | |
| GSE38129 | ACTR8 | 93973 | 218658_s_at | -0.3604 | 0.0000 | |
| GSE45670 | ACTR8 | 93973 | 222707_s_at | 0.0148 | 0.8871 | |
| GSE63941 | ACTR8 | 93973 | 222707_s_at | -0.1546 | 0.4967 | |
| GSE77861 | ACTR8 | 93973 | 222707_s_at | -0.1582 | 0.1888 | |
| GSE97050 | ACTR8 | 93973 | A_23_P80694 | -0.2049 | 0.4270 | |
| SRP007169 | ACTR8 | 93973 | RNAseq | 0.3501 | 0.4918 | |
| SRP008496 | ACTR8 | 93973 | RNAseq | 0.3869 | 0.2842 | |
| SRP064894 | ACTR8 | 93973 | RNAseq | 0.0371 | 0.7555 | |
| SRP133303 | ACTR8 | 93973 | RNAseq | -0.3740 | 0.0028 | |
| SRP159526 | ACTR8 | 93973 | RNAseq | -0.5439 | 0.0064 | |
| SRP193095 | ACTR8 | 93973 | RNAseq | -0.5228 | 0.0000 | |
| SRP219564 | ACTR8 | 93973 | RNAseq | -0.3588 | 0.1783 | |
| TCGA | ACTR8 | 93973 | RNAseq | -0.2444 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACTR8 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ACTR8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTR8 | 93973 | 0 | 17 | 13 | |
| GSE20123 | ACTR8 | 93973 | 0 | 18 | 12 | |
| GSE43470 | ACTR8 | 93973 | 0 | 18 | 25 | |
| GSE46452 | ACTR8 | 93973 | 2 | 17 | 40 | |
| GSE47630 | ACTR8 | 93973 | 1 | 24 | 15 | |
| GSE54993 | ACTR8 | 93973 | 6 | 2 | 62 | |
| GSE54994 | ACTR8 | 93973 | 0 | 32 | 21 | |
| GSE60625 | ACTR8 | 93973 | 5 | 0 | 6 | |
| GSE74703 | ACTR8 | 93973 | 0 | 14 | 22 | |
| GSE74704 | ACTR8 | 93973 | 0 | 12 | 8 | |
| TCGA | ACTR8 | 93973 | 0 | 79 | 17 |
Total number of gains: 14; Total number of losses: 233; Total Number of normals: 241.
Somatic mutations of ACTR8:
Generating mutation plots.
Highly correlated genes for ACTR8:
Showing top 20/192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTR8 | PSPN | 0.740453 | 3 | 0 | 3 |
| ACTR8 | SHOC2 | 0.695837 | 4 | 0 | 4 |
| ACTR8 | GPR17 | 0.68872 | 4 | 0 | 4 |
| ACTR8 | LYPD3 | 0.688024 | 3 | 0 | 3 |
| ACTR8 | KCNJ4 | 0.68487 | 3 | 0 | 3 |
| ACTR8 | AHNAK | 0.670961 | 4 | 0 | 4 |
| ACTR8 | TMEM40 | 0.669597 | 3 | 0 | 3 |
| ACTR8 | EREG | 0.664481 | 3 | 0 | 3 |
| ACTR8 | PFN4 | 0.65849 | 3 | 0 | 3 |
| ACTR8 | ZGLP1 | 0.650945 | 3 | 0 | 3 |
| ACTR8 | RNF151 | 0.649597 | 3 | 0 | 3 |
| ACTR8 | IL22RA1 | 0.649502 | 3 | 0 | 3 |
| ACTR8 | DNAJB8 | 0.647753 | 3 | 0 | 3 |
| ACTR8 | SRD5A2 | 0.646949 | 3 | 0 | 3 |
| ACTR8 | PAEP | 0.646429 | 3 | 0 | 3 |
| ACTR8 | WDR38 | 0.64567 | 4 | 0 | 3 |
| ACTR8 | GJB5 | 0.63757 | 4 | 0 | 3 |
| ACTR8 | MC5R | 0.636065 | 3 | 0 | 3 |
| ACTR8 | HMOX1 | 0.634444 | 4 | 0 | 3 |
| ACTR8 | RTCA | 0.63418 | 4 | 0 | 3 |
For details and further investigation, click here
