| Full name: interleukin 10 receptor subunit beta | Alias Symbol: CRF2-4|CDW210B|IL-10R2 | ||
| Type: protein-coding gene | Cytoband: 21q22.11 | ||
| Entrez ID: 3588 | HGNC ID: HGNC:5965 | Ensembl Gene: ENSG00000243646 | OMIM ID: 123889 |
| Drug and gene relationship at DGIdb | |||
IL10RB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05145 | Toxoplasmosis | |
| hsa05152 | Tuberculosis | |
| hsa05169 | Epstein-Barr virus infection |
Expression of IL10RB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL10RB | 3588 | 209575_at | -0.2747 | 0.7192 | |
| GSE20347 | IL10RB | 3588 | 209575_at | -0.7806 | 0.0000 | |
| GSE23400 | IL10RB | 3588 | 209575_at | -0.2532 | 0.0019 | |
| GSE26886 | IL10RB | 3588 | 209575_at | -1.1788 | 0.0003 | |
| GSE29001 | IL10RB | 3588 | 209575_at | -0.8484 | 0.0438 | |
| GSE38129 | IL10RB | 3588 | 209575_at | -0.5362 | 0.0024 | |
| GSE45670 | IL10RB | 3588 | 209575_at | -0.1430 | 0.3150 | |
| GSE53622 | IL10RB | 3588 | 39747 | -0.2817 | 0.0002 | |
| GSE53624 | IL10RB | 3588 | 39747 | -0.6396 | 0.0000 | |
| GSE63941 | IL10RB | 3588 | 209575_at | -0.0538 | 0.9068 | |
| GSE77861 | IL10RB | 3588 | 209575_at | -0.9876 | 0.0023 | |
| GSE97050 | IL10RB | 3588 | A_24_P322741 | 0.3817 | 0.4124 | |
| SRP007169 | IL10RB | 3588 | RNAseq | -1.1242 | 0.0045 | |
| SRP008496 | IL10RB | 3588 | RNAseq | -1.1565 | 0.0000 | |
| SRP064894 | IL10RB | 3588 | RNAseq | -0.1891 | 0.1605 | |
| SRP133303 | IL10RB | 3588 | RNAseq | -0.3407 | 0.0064 | |
| SRP159526 | IL10RB | 3588 | RNAseq | -0.6681 | 0.0397 | |
| SRP193095 | IL10RB | 3588 | RNAseq | -0.8416 | 0.0000 | |
| SRP219564 | IL10RB | 3588 | RNAseq | -0.7017 | 0.0792 | |
| TCGA | IL10RB | 3588 | RNAseq | -0.0906 | 0.0853 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by IL10RB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL10RB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL10RB | 3588 | 2 | 8 | 20 | |
| GSE20123 | IL10RB | 3588 | 2 | 9 | 19 | |
| GSE43470 | IL10RB | 3588 | 3 | 9 | 31 | |
| GSE46452 | IL10RB | 3588 | 1 | 21 | 37 | |
| GSE47630 | IL10RB | 3588 | 6 | 17 | 17 | |
| GSE54993 | IL10RB | 3588 | 9 | 1 | 60 | |
| GSE54994 | IL10RB | 3588 | 1 | 9 | 43 | |
| GSE60625 | IL10RB | 3588 | 0 | 0 | 11 | |
| GSE74703 | IL10RB | 3588 | 3 | 6 | 27 | |
| GSE74704 | IL10RB | 3588 | 1 | 4 | 15 | |
| TCGA | IL10RB | 3588 | 9 | 35 | 52 |
Total number of gains: 37; Total number of losses: 119; Total Number of normals: 332.
Somatic mutations of IL10RB:
Generating mutation plots.
Highly correlated genes for IL10RB:
Showing top 20/1538 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL10RB | TTC39B | 0.764105 | 4 | 0 | 4 |
| IL10RB | PSMA5 | 0.749422 | 3 | 0 | 3 |
| IL10RB | FAM83D | 0.737652 | 4 | 0 | 4 |
| IL10RB | TMEM54 | 0.734165 | 3 | 0 | 3 |
| IL10RB | PCBD2 | 0.729786 | 3 | 0 | 3 |
| IL10RB | ESYT2 | 0.728118 | 3 | 0 | 3 |
| IL10RB | SIAE | 0.724424 | 5 | 0 | 5 |
| IL10RB | RINT1 | 0.72171 | 5 | 0 | 4 |
| IL10RB | ARPC3 | 0.721297 | 10 | 0 | 10 |
| IL10RB | ZNF879 | 0.721016 | 3 | 0 | 3 |
| IL10RB | AQR | 0.71952 | 4 | 0 | 4 |
| IL10RB | NDUFS1 | 0.713761 | 3 | 0 | 3 |
| IL10RB | SCP2 | 0.710889 | 11 | 0 | 11 |
| IL10RB | SIKE1 | 0.707927 | 3 | 0 | 3 |
| IL10RB | DPH3 | 0.704712 | 3 | 0 | 3 |
| IL10RB | RBM47 | 0.704565 | 10 | 0 | 8 |
| IL10RB | SNX33 | 0.701192 | 4 | 0 | 4 |
| IL10RB | RNFT1 | 0.697757 | 5 | 0 | 4 |
| IL10RB | ZNF717 | 0.69624 | 3 | 0 | 3 |
| IL10RB | ZNF600 | 0.693094 | 3 | 0 | 3 |
For details and further investigation, click here
