| Full name: sialic acid binding Ig like lectin 1 | Alias Symbol: SIGLEC-1|CD169|FLJ00051|FLJ00055|FLJ00073|FLJ32150|dJ1009E24.1|sialoadhesin | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 6614 | HGNC ID: HGNC:11127 | Ensembl Gene: ENSG00000088827 | OMIM ID: 600751 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC1 | 6614 | 44673_at | -0.3354 | 0.6172 | |
| GSE20347 | SIGLEC1 | 6614 | 44673_at | 0.0536 | 0.6320 | |
| GSE23400 | SIGLEC1 | 6614 | 219519_s_at | 0.2453 | 0.0051 | |
| GSE26886 | SIGLEC1 | 6614 | 44673_at | -0.0313 | 0.8473 | |
| GSE29001 | SIGLEC1 | 6614 | 44673_at | 0.1913 | 0.3687 | |
| GSE38129 | SIGLEC1 | 6614 | 44673_at | -0.0276 | 0.8931 | |
| GSE45670 | SIGLEC1 | 6614 | 44673_at | -0.0718 | 0.7284 | |
| GSE53622 | SIGLEC1 | 6614 | 57833 | -0.0304 | 0.9065 | |
| GSE53624 | SIGLEC1 | 6614 | 57833 | 0.6512 | 0.0005 | |
| GSE63941 | SIGLEC1 | 6614 | 44673_at | -0.0045 | 0.9780 | |
| GSE77861 | SIGLEC1 | 6614 | 44673_at | -0.1263 | 0.3384 | |
| GSE97050 | SIGLEC1 | 6614 | A_23_P17481 | 0.3098 | 0.5827 | |
| SRP007169 | SIGLEC1 | 6614 | RNAseq | 3.2418 | 0.0004 | |
| SRP008496 | SIGLEC1 | 6614 | RNAseq | 2.6514 | 0.0000 | |
| SRP064894 | SIGLEC1 | 6614 | RNAseq | 1.2285 | 0.0036 | |
| SRP133303 | SIGLEC1 | 6614 | RNAseq | 0.3570 | 0.4353 | |
| SRP159526 | SIGLEC1 | 6614 | RNAseq | 0.0087 | 0.9896 | |
| SRP193095 | SIGLEC1 | 6614 | RNAseq | 0.5499 | 0.0850 | |
| SRP219564 | SIGLEC1 | 6614 | RNAseq | 1.4764 | 0.0985 | |
| TCGA | SIGLEC1 | 6614 | RNAseq | 0.0858 | 0.6441 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by SIGLEC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC1 | 6614 | 12 | 3 | 15 | |
| GSE20123 | SIGLEC1 | 6614 | 13 | 3 | 14 | |
| GSE43470 | SIGLEC1 | 6614 | 10 | 1 | 32 | |
| GSE46452 | SIGLEC1 | 6614 | 26 | 1 | 32 | |
| GSE47630 | SIGLEC1 | 6614 | 18 | 4 | 18 | |
| GSE54993 | SIGLEC1 | 6614 | 2 | 14 | 54 | |
| GSE54994 | SIGLEC1 | 6614 | 24 | 2 | 27 | |
| GSE60625 | SIGLEC1 | 6614 | 0 | 0 | 11 | |
| GSE74703 | SIGLEC1 | 6614 | 9 | 1 | 26 | |
| GSE74704 | SIGLEC1 | 6614 | 8 | 1 | 11 | |
| TCGA | SIGLEC1 | 6614 | 39 | 11 | 46 |
Total number of gains: 161; Total number of losses: 41; Total Number of normals: 286.
Somatic mutations of SIGLEC1:
Generating mutation plots.
Highly correlated genes for SIGLEC1:
Showing top 20/551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC1 | RGS18 | 0.745798 | 3 | 0 | 3 |
| SIGLEC1 | C19orf38 | 0.730699 | 3 | 0 | 3 |
| SIGLEC1 | C1QC | 0.726902 | 6 | 0 | 6 |
| SIGLEC1 | ITIH5 | 0.720737 | 3 | 0 | 3 |
| SIGLEC1 | GIMAP5 | 0.713275 | 3 | 0 | 3 |
| SIGLEC1 | LILRA2 | 0.707037 | 3 | 0 | 3 |
| SIGLEC1 | NRXN2 | 0.699087 | 3 | 0 | 3 |
| SIGLEC1 | FOXP4 | 0.698367 | 3 | 0 | 3 |
| SIGLEC1 | C1QA | 0.694754 | 10 | 0 | 7 |
| SIGLEC1 | TCEA2 | 0.693505 | 3 | 0 | 3 |
| SIGLEC1 | C5AR1 | 0.693258 | 6 | 0 | 6 |
| SIGLEC1 | STAB1 | 0.693248 | 10 | 0 | 10 |
| SIGLEC1 | TMEM140 | 0.689221 | 9 | 0 | 9 |
| SIGLEC1 | MPEG1 | 0.688029 | 5 | 0 | 5 |
| SIGLEC1 | PRR29 | 0.68489 | 3 | 0 | 3 |
| SIGLEC1 | PTGIS | 0.682843 | 4 | 0 | 4 |
| SIGLEC1 | DPEP2 | 0.682527 | 7 | 0 | 7 |
| SIGLEC1 | ZFAND3 | 0.67696 | 3 | 0 | 3 |
| SIGLEC1 | REC8 | 0.676551 | 4 | 0 | 4 |
| SIGLEC1 | GALM | 0.672038 | 5 | 0 | 5 |
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